Marginal-zone B-cell Lymphoma of the Bony Palate presenting as Sinusitis

Ayers, Lisa Skultety; Oxenberg, Jacqueline; Zwillenberg, Seth; Ghaderi, Mahmoud

doi:10.1177/014556130808700112

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…The most frequent clinical appearance of palatal MALT lymphomas is non-tender yet rarely ulcerated mass [ 8 ]. To our knowledge, only two previous reports described ulcerated masses associated with palatal MALT lymphomas [ 1 , 7 ]. Our patient also presented with ulceration located at the center of the hard palate.…”

Section: Discussionmentioning

confidence: 99%

Primary B-Cell Mucosa-Associated Lymphoid Tissue Lymphoma of the Hard Palate and Parotid Gland: Report of One Case and Review of the Literature

Yonal-Hindilerden¹,

Hindilerden²,

Arslan³

et al. 2016

J Clin Med Res

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A 61-year-old woman was admitted to our hospital with an ulcerated palate mass and swelling of the right parotid gland. Incisional biopsy from the hard palate revealed an extranodal marginal zone B-cell lymphoma, also called mucosa-associated lymphoid tissue (MALT) lymphoma. Final diagnosis was MALT lymphoma of the parotid gland with concomitant involvement of an extremely seldom site of involvement: the hard palate. To our knowledge, this report illustrates the first case of MALT lymphoma of the hard palate and parotid gland without an underlying autoimmune disease. Rituximab-based combination regimen (R-CHOP) provided complete remission with total regression of mass lesions at the hard palate and parotid gland. At 44-month follow-up, there is no disease relapse. We adressed the manifestations and management of MALT lymphoma patients with involvement of salivary gland and oral cavity.

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Section: Discussionmentioning

confidence: 99%

Primary B-Cell Mucosa-Associated Lymphoid Tissue Lymphoma of the Hard Palate and Parotid Gland: Report of One Case and Review of the Literature

Yonal-Hindilerden¹,

Hindilerden²,

Arslan³

et al. 2016

J Clin Med Res

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“…Lymphoma is one of the most common malignancies in the oropharyngeal region 5,12 . Follicular center cell and marginal zone‐type low‐grade B‐cell lymphomas are more commonly seen in the palate, 13,14 whereas high‐grade diffuse large B‐cell lymphomas are more common in the maxilla and gingiva 11 . The diffuse mixed small and large B‐cell lymphoma is reported to account for 20% of all PE NHL in the oral region 15 .…”

Section: Discussionmentioning

confidence: 99%

Primary Non‐Hodgkin Lymphoma of Palatal Gingiva

Sharma

Yadav

Kataria

et al. 2012

Clin Adv Periodontics

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Introduction: Non‐Hodgkin lymphomas (NHLs) are a heterogeneous group of lymphoproliferative malignancies that can disseminate to organs and tissues that do not ordinarily contain lymphoid cells (extranodal sites). Primary extranodal NHL of the oral cavity is rare, and gingiva is one of the rarest intraoral sites involved. The majority of oral NHLs reported are of diffuse large B‐cell type. Such lymphomas are more prevalent in immunocompromised patients. Because of their malignant nature, early recognition, diagnosis, and treatment are essential for a patient's survival. To the best of our knowledge, this report presents the first case of diffuse mixed small and large B‐cell lymphoma involving the gingiva in a non‐immunocompromised patient. Case Presentation: A female patient presented with a growth located on the palatal aspect of the right maxillary molar region involving marginal and interdental gingiva. Routine laboratory tests and clinical examination were within normal limits. An incisional biopsy of the gingival tissue was evaluated using histologic techniques and immunohistochemistry. A diagnosis of extranodal diffuse mixed small and large B‐cell lymphoma was established. The patient underwent a complete workup to rule out other systemic lesions, thereby supporting the primary nature of the lesion. Conclusion: Gingival overgrowth may rarely be the first manifestation of extranodal NHL. Only histopathological examination of the specimen with immunohistochemistry can ascertain a confirmed diagnosis of NHL. The present case report stresses the importance of routine biopsy examination for growth lesions of long duration when an infectious etiology has been ruled out, even if the lesions appear benign.

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Primary oral mucosa-associated lymphoid tissue (MALT) lymphoma in patient with monoclonale gammopathy: a rare case report

et al. 2021

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Background Monoclonal gammopathy is a biological reality encountered in approximately 1% of the general population. In the absence of clinical and biological signs, it is considered of undetermined significance; however, it can be a biological signature of a monoclonal lymphocytic or plasma-cell proliferation. Their localisation to the oral mucosa remains rare and difficult to diagnose, particularly in indolent forms that escape imaging techniques. Case presentation Here, we report the case of a 73-year-old woman with a history of IgM kappa gammopathy followed for 13 years. The patient did not have a chronic infection or an autoimmune disease, and all the biological investigations and radiological explorations were unremarkable during this period. The discovery of a submucosal nodule in the cheek led to the diagnosis of MALT lymphoma and regression of half of the IgM kappa level after resection. The review of the literature shows the dominance of clinical signs (i.e., a mass or swelling) in the diagnosis of primary MALT lymphomas of the oral cavity after surgical resection. Conclusions Our case illustrates the role of examination of the oral cavity in the context of a monoclonal gammopathy. The absence of clinical and radiological evidence in favor of lymphoplasmacytic proliferation, does not exclude a primary indolent MALT lymphoma of the oral mucosa.

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Marginal-zone B-cell Lymphoma of the Bony Palate presenting as Sinusitis

Cited by 4 publications

References 11 publications

Primary B-Cell Mucosa-Associated Lymphoid Tissue Lymphoma of the Hard Palate and Parotid Gland: Report of One Case and Review of the Literature

Primary B-Cell Mucosa-Associated Lymphoid Tissue Lymphoma of the Hard Palate and Parotid Gland: Report of One Case and Review of the Literature

Primary Non‐Hodgkin Lymphoma of Palatal Gingiva

Primary oral mucosa-associated lymphoid tissue (MALT) lymphoma in patient with monoclonale gammopathy: a rare case report

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