Marijuana Use for Women: To Prescribe or Not to Prescribe

Huang, Lei; Zhang, Xinyue; Xu, Aman

doi:10.1080/10826084.2020.1782938

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…Various cannabinoids have been shown to interact with the endocrine system and have been noted to act as endocrine disruptors in ovaries, testes and placenta [ 126–130 ], and cannabinoids are also involved in breast pathophysiology [ 11 , 131 ] and are normally excreted in breast milk [ 132 , 133 ]. Endocrine disruption has been noted to be a powerful negative impactor of human health [ 134 , 135 ].…”

Section: Discussionmentioning

confidence: 99%

“…Agonists at the Type 1 and 2 cannabinoid receptors (CB1R and CB2R) are known to interfere with the hypothalamic-pituitary-gonadal axis in human females [ 11 ], hypothalamic-pituitary-adrenal axis [ 136–138 ], with insulin [ 139 , 140 ] and other hormones and to stimulate human prolactin levels [ 141–143 ]. Various cannabinoid concentrations have been noted both to stimulate [ 131 ] and inhibit [ 144–146 ] the growth of BC cells in culture.…”

Section: Discussionmentioning

confidence: 99%

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Geospatiotemporal and causal inference study of cannabis and other drugs as risk factors for female breast cancer USA 2003–2017

Reece

Hulse

2022

Environmental Epigenetics

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Introduction Breast cancer (BC) is the commonest human cancer and its incidence (BCI) is rising worldwide. Whilst both tobacco and alcohol have been linked to BCI genotoxic cannabinoids have not been investigated. Methods Age-adjusted state-based BC incidence (BCI) 2003-2017 was taken from the Surveillance Epidemiology and End Results database of the Centers for Disease Control (CDC). Drug use from the National Survey of Drug Use and Health, response rate 74.1%. Median age, median household income and ethnicity were from US census. Inverse probability weighted (ipw) multivariable regression conducted in R. Results In bivariate analysis BCI was shown to be significantly linked with rising cannabis exposure (β-est.=3.93 (95%C.I. 2.99, 4.87), P=1.10x10-15). At 8-years lag cigarettes: cannabis (β-est.=2660 (2150.4, 3169.3), P=4.60x10-22) and cannabis: alcoholism (β-est.=7010 (5461.6, 8558.4), P=1.80x10-17) were significant in ipw-panel regression. Terms including cannabidiol (β-est.=16.16 (0.39, 31.93), P=0.446) and cannabigerol (β-est.=6.23 (2.06, 10.39), P=0.0034) were significant in spatiotemporal models lagged 1:2 years respectively. Cannabis-liberal paradigms had higher BCI (67.50±0.26 v. 65.19±0.21/100,000 (mean±S.E.M.), P=1.87x10-11; β-est.= 2.31 (1.65, 2.96), P = 9.09x10-12). 55/58 e-Values >1.25 and 13/58 >100. Abortion was independently and causally significant in space-time models. Conclusion Data show that exposure to cannabis and the cannabinoids THC, cannabidiol, cannabigerol, and alcoholism fulfill quantitative causal criteria for BCI across space and time. Findings are robust to adjustment for age and several known sociodemographic, socioeconomic and hormonal risk factors, and establish cannabinoids as an additional risk factor class for breast carcinogenesis. BCI is higher under cannabis-liberal legal paradigms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Geospatiotemporal and causal inference study of cannabis and other drugs as risk factors for female breast cancer USA 2003–2017

Reece

Hulse

2022

Environmental Epigenetics

View full text Add to dashboard Cite

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“… 15 These effects include increased risk of addiction to marijuana and other substances, motor vehicle accidents, cardiovascular complications in otherwise young and healthy patients, chronic bronchitis, and decreased lifetime achievement. 16 - 18 Additionally, the use of marijuana can lead to the use of other drugs, abnormal brain development, schizophrenia, depression, and anxiety. A low risk of lung cancer in addition to other cancers has also been associated with its use.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Cannabinoids on Sleep

Kolla

Hayes

Cox

et al. 2022

J Prim Care Community Health

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The use of cannabis products to help with sleep and various other medical conditions by the public has increased significantly in recent years. Withdrawal from cannabinoids can lead to sleep disturbance. Here, we describe a patient who developed significant insomnia leading to worsening anxiety, mood, and suicidal ideation in the setting of medical cannabis withdrawal, prompting presentation to the Emergency Department and inpatient admission. There is a limited evidence base for the use of cannabis products for sleep. We provide a comprehensive review evaluating the literature on the use of cannabis products on sleep, including an overview of cannabis and related psychoactive compounds, the current state of the law as it pertains to the prescribing and use of these substances, and potential side effects and drug interactions. We specifically discuss the impact of cannabis products on normal sleep and circadian sleep-wake rhythms, insomnia, excessive daytime sleepiness, sleep apnea, parasomnias, and restless legs syndrome. We also describe the effects of cannabis withdrawal on sleep and how this increases relapse to cannabis use. Most of the studies are observational but the few published randomized controlled trials are reviewed. Our comprehensive review of the effects of cannabis products on normal sleep and sleep disorders, relevant to primary care providers and other clinicians evaluating and treating patients who use these types of products, shows that cannabis products have minimal to no effects on sleep disorders and may have deleterious effects in some individuals. Further research examining the differential impact of the various types of cannabinoids that are currently available on each of these sleep disorders is required.

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Causal relationship between cannabis use and cancer: a genetically informed perspective

Huang

Zhang

2023

J Cancer Res Clin Oncol

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Marijuana Use for Women: To Prescribe or Not to Prescribe

Cited by 5 publications

References 9 publications

Geospatiotemporal and causal inference study of cannabis and other drugs as risk factors for female breast cancer USA 2003–2017

Geospatiotemporal and causal inference study of cannabis and other drugs as risk factors for female breast cancer USA 2003–2017

The Effects of Cannabinoids on Sleep

Causal relationship between cannabis use and cancer: a genetically informed perspective

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