Marine Alkaloids: Compounds with In Vivo Activity and Chemical Synthesis

Munekata, Paulo E. S.; Pateiro, Mirian; Conté-Júnior, Carlos Adam; Domínguez, Rubén; Nawaz, Asad; Walayat, Noman; Fierro, Elena Movilla; Lorenzo, José M.

doi:10.3390/md19070374

Cited by 16 publications

(16 citation statements)

References 87 publications

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“…A similar approach was used to analyze natural foods with antioxidant properties (curcuma, papain, bromelain and black pepper), which showed anabolic effects during development and reduced osteoclastic activity in zebrafish scales [ 160 ]. Zebrafish have been of interest to also test marine alkaloids [ 161 ], which altogether shall boost the discovery of potential alternative therapeutics.…”

Section: Zebrafish As Animal Models To Accelerate Discoveries Of Huma...mentioning

confidence: 99%

Functional Validation of Osteoporosis Genetic Findings Using Small Fish Models

Kague

Karasik

2022

Genes

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The advancement of human genomics has revolutionized our understanding of the genetic architecture of many skeletal diseases, including osteoporosis. However, interpreting results from human association studies remains a challenge, since index variants often reside in non-coding regions of the genome and do not possess an obvious regulatory function. To bridge the gap between genetic association and causality, a systematic functional investigation is necessary, such as the one offered by animal models. These models enable us to identify causal mechanisms, clarify the underlying biology, and apply interventions. Over the past several decades, small teleost fishes, mostly zebrafish and medaka, have emerged as powerful systems for modeling the genetics of human diseases. Due to their amenability to genetic intervention and the highly conserved genetic and physiological features, fish have become indispensable for skeletal genomic studies. The goal of this review is to summarize the evidence supporting the utility of Zebrafish (Danio rerio) for accelerating our understanding of human skeletal genomics and outlining the remaining gaps in knowledge. We provide an overview of zebrafish skeletal morphophysiology and gene homology, shedding light on the advantages of human skeletal genomic exploration and validation. Knowledge of the biology underlying osteoporosis through animal models will lead to the translation into new, better and more effective therapeutic approaches.

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Section: Zebrafish As Animal Models To Accelerate Discoveries Of Huma...mentioning

confidence: 99%

Functional Validation of Osteoporosis Genetic Findings Using Small Fish Models

Kague

Karasik

2022

Genes

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“…Alkaloids are a large group of structurally diverse natural compounds, that contain at least one nitrogen atom, with great potential for drug development to treat diseases and mental disorders [ 127 ]. Marine sponges provide an abundant resource of bioactive alkaloid compounds [ 128 ].…”

Section: Antiviral Activity Against Sars-cov-2 In Marine Resourcesmentioning

confidence: 99%

Focus on Marine Animal Safety and Marine Bioresources in Response to the SARS-CoV-2 Crisis

Yang

Han

2022

IJMS

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SARS-CoV-2 as a zoonotic virus has significantly affected daily life and social behavior since its outbreak in late 2019. The concerns over its transmission through different media directly or indirectly have evoked great attention about the survival of SARS-CoV-2 virions in the environment and its potential infection of other animals. To evaluate the risk of infection by SARS-CoV-2 and to counteract the COVID-19 disease, extensive studies have been performed to understand SARS-CoV-2 biogenesis and its pathogenesis. This review mainly focuses on the molecular architecture of SARS-CoV-2, its potential for infecting marine animals, and the prospect of drug discovery using marine natural products to combat SARS-CoV-2. The main purposes of this review are to piece together progress in SARS-CoV-2 functional genomic studies and antiviral drug development, and to raise our awareness of marine animal safety on exposure to SARS-CoV-2.

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“…In fact, the research led to the discovery of many anticancer compounds from marine sponges, which have not yet been tested on humans, except for the Eribulin mesylate (an analogue of halichondrin B), which has been tested on women with breast cancer [10]. Many clinical trials were made through experimental models, 2 of 22 such as the mice and zebrafish, representing a step forward in the evaluation of possible adverse effects not detectable by in in vitro tests [11]. The discovery of marine natural products has accelerated in the last two decades with the number of new compounds discovered each year increasing from 20 to more than 200 [12].…”

Section: Introduction 1natural Products From Marine Organismsmentioning

confidence: 99%

Marine Demospongiae: A Challenging Treasure of Bioactive Compounds

et al. 2022

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In the last decades, it has been demonstrated that marine organisms are a substantial source of bioactive compounds with possible biotechnological applications. Marine sponges, in particular those belonging to the class of Demospongiae, have been considered among the most interesting invertebrates for their biotechnological potential. In this review, particular attention is devoted to natural compounds/extracts isolated from Demospongiae and their associated microorganisms with important biological activities for pharmacological applications such as antiviral, anticancer, antifouling, antimicrobial, antiplasmodial, antifungal and antioxidant. The data here presented show that this class of sponges is an exciting source of compounds, which are worth developing into new drugs, such as avarol, a hydroquinone isolated from the marine sponge Disidea avara, which is used as an antitumor, antimicrobial and antiviral drug.

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Marine Alkaloids: Compounds with In Vivo Activity and Chemical Synthesis

Cited by 16 publications

References 87 publications

Functional Validation of Osteoporosis Genetic Findings Using Small Fish Models

Functional Validation of Osteoporosis Genetic Findings Using Small Fish Models

Focus on Marine Animal Safety and Marine Bioresources in Response to the SARS-CoV-2 Crisis

Marine Demospongiae: A Challenging Treasure of Bioactive Compounds

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