Marine collagen and its derivatives: Versatile and sustainable bio-resources for healthcare

Salvatore, Luca; Gallo, Nunzia; Natali, Maria Lucia; Campa, Lorena; Lunetti, Paola; Madaghiele, Marta; Blasi, Federica Stella; Corallo, Angelo; Capobianco, Loredana; Sannino, Alessandro

doi:10.1016/j.msec.2020.110963

Cited by 137 publications

(114 citation statements)

References 207 publications

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“…Therefore, marine collagen, such as Nile Tilapia, is one of the major collagen sources, which can be alternative to mammalian-derived collagen. Marine collagen is a safer and more attractive biomaterial for processing using advanced fabrication techniques, confirming the growing relevance of marine biomaterials in tissue engineering and regenerative medicine [46][47][48][49][50] . Although further research is needed, the skin of Nile Tilapia had a therapeutic effect on burn wounds in human clinical trials 51 .…”

Section: Discussionmentioning

confidence: 72%

Manufacturing micropatterned collagen scaffolds with chemical-crosslinking for development of biomimetic tissue-engineered oral mucosa

Suzuki

Kodama²,

Miwa

et al. 2020

Sci Rep

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The junction between the epithelium and the underlying connective tissue undulates, constituting of rete ridges, which lack currently available soft tissue constructs. In this study, using a micro electro mechanical systems process and soft lithography, fifteen negative molds, with different dimensions and aspect ratios in grid- and pillar-type configurations, were designed and fabricated to create three-dimensional micropatterns and replicated onto fish-scale type I collagen scaffolds treated with chemical crosslinking. Image analyses showed the micropatterns were well-transferred onto the scaffold surfaces, showing the versatility of our manufacturing system. With the help of rheological test, the collagen scaffold manufactured in this study was confirmed to be an ideal gel and have visco-elastic features. As compared with our previous study, its mechanical and handling properties were improved by chemical cross-linking, which is beneficial for grafting and suturing into the complex structures of oral cavity. Histologic evaluation of a tissue-engineered oral mucosa showed the topographical microstructures of grid-type were well-preserved, rather than pillar-type, a well-stratified epithelial layer was regenerated on all scaffolds and the epithelial rete ridge-like structure was developed. As this three-dimensional microstructure is valuable for maintaining epithelial integrity, our micropatterned collagen scaffolds can be used not only intraorally but extraorally as a graft material for human use.

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Section: Discussionmentioning

confidence: 72%

Manufacturing micropatterned collagen scaffolds with chemical-crosslinking for development of biomimetic tissue-engineered oral mucosa

Suzuki

Kodama²,

Miwa

et al. 2020

Sci Rep

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“…Gelatin production Moreover, due to its gel-forming properties, marine gelatin is also applied in food industry as a stabilizer, texturizer, thickener and foaming agent in yoghurt, ice-cream, jam, cream cheese, marshmallows, etc. [303,304]. Presumably, due to the lower content of proline and hydroxyproline in comparison to beef-and pork-derived gelatins [294,305], marine gelatins form "weaker gels" [306,307].…”

Section: Patentsmentioning

confidence: 99%

“…Presumably, due to the lower content of proline and hydroxyproline in comparison to beef-and pork-derived gelatins [294,305], marine gelatins form "weaker gels" [306,307]. Notably, gelatin inhibits peroxidation preventing food from deterioration and functions as an outer protective film against dehydration, oxygen, and light [304]. In addition, isinglass, a high-grade gelatin derived from fish swim bladders that can induce aggregation of yeast and other insoluble particles, can be widely applied as a commercial clarifier in beverages, i.e., wine, beer, cider [303].…”

Section: Patentsmentioning

confidence: 99%

“…In addition, isinglass, a high-grade gelatin derived from fish swim bladders that can induce aggregation of yeast and other insoluble particles, can be widely applied as a commercial clarifier in beverages, i.e., wine, beer, cider [303]. Though marine gelatin may trigger allergy, i.e., 0%-8% incidence depending on local food habits and fish consumption is reported [304]. Finally, marine gelatin is widely used in capsule industry.…”

Section: Patentsmentioning

confidence: 99%

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Progress in Modern Marine Biomaterials Research

et al. 2020

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The growing demand for new, sophisticated, multifunctional materials has brought natural structural composites into focus, since they underwent a substantial optimization during long evolutionary selection pressure and adaptation processes. Marine biological materials are the most important sources of both inspiration for biomimetics and of raw materials for practical applications in technology and biomedicine. The use of marine natural products as multifunctional biomaterials is currently undergoing a renaissance in the modern materials science. The diversity of marine biomaterials, their forms and fields of application are highlighted in this review. We will discuss the challenges, solutions, and future directions of modern marine biomaterialogy using a thorough analysis of scientific sources over the past ten years.

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“…There are also religious barriers to the use of bovine and porcine products in many cultures [ 24 ]. Marine-based collagens have so far been under-utilized, however there has been increasing interest in them in recent years [ 1 , 25 ], particularly for use as biomaterials for tissue engineering [ 26 ]. Marine collagens offer an attractive alternative due to their low risk of pathogen transmission and lack of religious constraints.…”

Section: Introductionmentioning

confidence: 99%

Light Cross-Linkable Marine Collagen for Coaxial Printing of a 3D Model of Neuromuscular Junction Formation

et al. 2020

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Collagen is a major component of the extracellular matrix (ECM) that modulates cell adhesion, growth, and migration, and has been utilised in tissue engineering applications. However, the common terrestrial sources of collagen carry the risk of zoonotic disease transmission and there are religious barriers to the use of bovine and porcine products in many cultures. Marine based collagens offer an attractive alternative and have so far been under-utilized for use as biomaterials for tissue engineering. Marine collagen can be extracted from fish waste products, therefore industry by-products offer an economical and environmentally sustainable source of collagen. In a handful of studies, marine collagen has successfully been methacrylated to form collagen methacrylate (ColMA). Our work included the extraction, characterization and methacrylation of Red Snapper collagen, optimisation of conditions for neural cell seeding and encapsulation using the unmodified collagen, thermally cross-linked, and the methacrylated collagen with UV-induced cross-linking. Finally, the 3D co-axial printing of neural and skeletal muscle cell cultures as a model for neuromuscular junction (NMJ) formation was investigated. Overall, the results of this study show great potential for a novel NMJ in vitro 3D bioprinted model that, with further development, could provide a low-cost, customizable, scalable and quick-to-print platform for drug screening and to study neuromuscular junction physiology and pathogenesis.

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Marine collagen and its derivatives: Versatile and sustainable bio-resources for healthcare

Cited by 137 publications

References 207 publications

Manufacturing micropatterned collagen scaffolds with chemical-crosslinking for development of biomimetic tissue-engineered oral mucosa

Manufacturing micropatterned collagen scaffolds with chemical-crosslinking for development of biomimetic tissue-engineered oral mucosa

Progress in Modern Marine Biomaterials Research

Light Cross-Linkable Marine Collagen for Coaxial Printing of a 3D Model of Neuromuscular Junction Formation

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