Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice

Pei, Xinrong; Yang, Ruiyue; Zhang, Zhaofeng; Gao, Lifang; Wang, Junbo; Xu, Yuping; Zhao, Ming; Han, Xiaolong; Liu, Zhigang; Li, Yong

doi:10.1016/j.foodchem.2009.04.120

Cited by 92 publications

(76 citation statements)

References 37 publications

(39 reference statements)

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“…In agreement with the results, our previous study suggested administration of 0.22%, 0.44%, and 1.32% MCPs for 3 months could dosedependently increase the activity of SOD and GSH-PX and decrease the level of TBARS in aged C57BL/6J mice. 50 In a previous study of our laboratory, MCPs were suggested to exhibit significant radical scavenging activity and anti-lipid peroxidation activity, which were assessed with a 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay (the 50% inhibitory concentration value of MCPs to scavenge 2,2-diphenyl-1-picrylhydrazyl radical was 20.719 mg/mL) and linoleic acid peroxidation system (10 mg/mL MCPs inhibited 58.69% linoleic acid oxidation after a 2-hour incubation), respectively. 51,52 Therefore, MCPs was presumed to react with radicals in the system and thereby directly inhibit the formation of lipid peroxidation product, such as MDA.…”

Section: Discussionmentioning

confidence: 99%

Marine Collagen Peptides Prepared from Chum Salmon (Oncorhynchus keta) Skin Extend the Life Span and Inhibit Spontaneous Tumor Incidence in Sprague-Dawley Rats

Jiang

Pei

Wang

et al. 2010

Journal of Medicinal Food

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To observe the effects of marine collagen peptides (MCPs) prepared from chum salmon (Oncorhynchus keta) skin on life span and spontaneous tumor incidence, Sprague-Dawley rats were fed diets supplemented with MCP at concentrations of 0%, 2.25%, 4.5%, and 9% (wt/wt) from the age of 4 weeks until natural death. There were 40 rats in each group (male:female ratio = 1:1). The results showed that the MCP did not significantly influence body weight or food consumption of rats of either sex throughout the life span; it did dose-dependently inhibit the age-related decrease in the activities of antioxidant enzymes and the age-related increase in the levels of lipid peroxidation product in both sexes. MCP notably increased the mean life span, the life span of the last 30% of the survivors, and the maximal life span; it decreased overall spontaneous tumor incidence of both sexes with significance in the 4.5% and 9% MCP-treated male groups and 9% MCP-treated female group. Compared to the control group, the incidence of death from tumors was decreased in MCP groups in comparison with the control group of both sexes. Therefore, we concluded that MCPs dose-dependently increase life span and decrease spontaneous tumor incidence in Sprague-Dawley rats. Moreover, the antioxidative property of MCPs may be responsible for the increased life span and protection against tumor development.

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Section: Discussionmentioning

confidence: 99%

Marine Collagen Peptides Prepared from Chum Salmon (Oncorhynchus keta) Skin Extend the Life Span and Inhibit Spontaneous Tumor Incidence in Sprague-Dawley Rats

Jiang

Pei

Wang

et al. 2010

Journal of Medicinal Food

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“…The procedure of MCP preparation and identification was according to the method described in our previous research [23]. Briefly, the fish skin was cleaned, scaled, cut into small pieces, defatted and homogenized.…”

Section: Methodsmentioning

confidence: 99%

A Chronic Oral Toxicity Study of Marine Collagen Peptides Preparation from Chum Salmon (Oncorhynchus keta) Skin Using Sprague-Dawley Rat

et al. 2011

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Due to the increased consumption of marine collagen peptides preparation (MCP) as ingredients in functional foods and pharmaceuticals, it was necessary to carry out safety requirements in the form of an oral chronic toxicity assessment. In order to define the oral chronic toxicity of MCP, a 24-month feeding study of MCP was carried out. Sprague-Dawley (S-D) rats at the age of four-week of both sexes were treated with MCP at the diet concentrations of 0%, 2.25%, 4.5%, 9% and 18% (wt/wt). The actual food intake and bodyweight of the individual animals were recorded periodically until sacrifice. Blood and urine samples were collected for serum chemistry evaluations and urinalysis. Throughout the experimental period, there was no toxicologically significant difference between the vehicle and MCP-treated animals with respect to the survival rate, body weight, food consumption, urinalysis, clinical biochemistry parameter and relative organ weight in either sex. Moreover, incidences of non-neoplastic lesions in MCP-treated groups did not significantly increase compared with the control group. Under the present experimental conditions, no higher risk of chronic toxic effects was observed in MCP-treated rats at the diet concentrations of 2.25%, 4.5%, 9% and 18% (wt/wt) than in the rats fed with basal rodent diet.

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“…Muthukumar et al reported that SC is suppressing inflammation in the experimental wound model by regulation of nitric oxide synthase (iNOS) and other growths factors. iNOS is considered to be an important determinant of colonic damage [36]. We already reported that one possible anti-inflammatory mechanism of chitosan oligosaccharide is suppressing the activation of iNOS [37].…”

Section: Discussionmentioning

confidence: 98%

Effects of fish scale collagen peptide on an experimental ulcerative colitis mouse model

Aso¹,

Osaki²,

Tsuka³

et al. 2014

PharmaNutrition

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Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice

Cited by 92 publications

References 37 publications

Marine Collagen Peptides Prepared from Chum Salmon (Oncorhynchus keta) Skin Extend the Life Span and Inhibit Spontaneous Tumor Incidence in Sprague-Dawley Rats

Marine Collagen Peptides Prepared from Chum Salmon (Oncorhynchus keta) Skin Extend the Life Span and Inhibit Spontaneous Tumor Incidence in Sprague-Dawley Rats

A Chronic Oral Toxicity Study of Marine Collagen Peptides Preparation from Chum Salmon (Oncorhynchus keta) Skin Using Sprague-Dawley Rat

Effects of fish scale collagen peptide on an experimental ulcerative colitis mouse model

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