Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity

Althagbi, Hanan I.; Alarif, Walied M.; Al-Footy, Khalid O.; Abdel‐Lateff, Ahmed

doi:10.3390/md18070368

Cited by 27 publications

(21 citation statements)

References 132 publications

(313 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Manzamine A ( Figure 2 B) was isolated for the first time from the marine sponge Haliclona sp. in 1986 [ 129 ]. Its activity to inhibit the GSK3beta enzyme noncompetitively was later discovered by in vitro studies when it was observed that an increase in the concentration of ATP did not cause a change in its inhibitory activity.…”

Section: Marine Compounds Against Alzheimer’s Disease: From Sea To Cellsmentioning

confidence: 99%

“…About 100 manzamine alkaloids have been isolated from more than 16 species of marine sponges belonging to 10 genera ( Amphimedon, Pachypellina, Haliclona, Reniera, Cribochalina, Petrosia, Ircinia, Hyrtios, Acanthostrongylophora, and Xestospongia ) and belonging to five families (Chalinidae, Niphatidae, Petrosiidae, Thorectidae, Irciniidae). These sponges are found in Okinawa, the Philippines, Indonesia, the Red Sea, Italy, South Africa, and Papua New Guinea [ 128 , 129 ]. AlTarabeen and colleages purified seven manzamines (ircinal E, manzamine A, 8-hydroxymanzamine A, manzamine F, manzamine A N-oxide, 3,4-dihydromanzamine A N-oxide, and nakadomarin A) from Acanthostrongylophora ingens collected at Ambon, Indonesia [ 153 ].…”

Section: Isolation Of High-value Molecules With Neuroprotective Effects Against Alzheimer’s Diseasementioning

confidence: 99%

See 1 more Smart Citation

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

2021

View full text Add to dashboard Cite

Neurodegenerative diseases are sociosanitary challenges of today, as a result of increased average life expectancy, with Alzheimer’s disease being one of the most prevalent. This pathology is characterized by brain impairment linked to a neurodegenerative process culminating in cognitive decline and behavioral disorders. Though the etiology of this pathology is still unknown, it is usually associated with the appearance of senile plaques and neurofibrillary tangles. The most used prophylaxis relies on anticholinesterase drugs and NMDA receptor antagonists, whose main action is to relieve symptoms and not to treat or prevent the disease. Currently, the scientific community is gathering efforts to disclose new natural compounds effective against Alzheimer’s disease and other neurodegenerative pathologies. Marine natural products have been shown to be promising candidates, and some have been proven to exert a high neuroprotection effect, constituting a large reservoir of potential drugs and nutraceutical agents. The present article attempts to describe the processes of extraction and isolation of bioactive compounds derived from sponges, algae, marine bacteria, invertebrates, crustaceans, and tunicates as drug candidates against AD, with a focus on the success of pharmacological activity in the process of finding new and effective drug compounds.

show abstract

Section: Marine Compounds Against Alzheimer’s Disease: From Sea To Cellsmentioning

confidence: 99%

Section: Isolation Of High-value Molecules With Neuroprotective Effects Against Alzheimer’s Diseasementioning

confidence: 99%

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

2021

View full text Add to dashboard Cite

show abstract

“…Alkaloids are the most well-known cytotoxic compounds of MNPs isolated from sponges (Althagbi et al 2020 ) and have established their superiority among other classes of compounds (Izzati et al 2021 ). A relatively common moiety found is the β-carboline (a tricyclic 9 H -pyrido[3,4-b]indole ring structure), also known as norharman (Cao et al 2007 ).…”

Section: Discussionmentioning

confidence: 99%

“…Indonesian marine sponges also provide nitrogenous alkaloid compounds besides the exclusive β-carboline group (Althagbi et al 2020 ). Two of the recent ones are haliclocyclamines C ( 11 ) and cyclostellettamines F ( 12 ), which were isolated from Haliclona sp.…”

Section: Discussionmentioning

confidence: 99%

Structure–Activity Relationship of Cytotoxic Natural Products from Indonesian Marine Sponges

Panggabean

Adiguna

Murniasih³

et al. 2022

Rev. Bras. Farmacogn.

View full text Add to dashboard Cite

Graphical abstract Indonesian marine natural products have been one of the most promising sources in the race to obtain potential drugs for cancer treatment. One of the primary producers of cytotoxic compounds is sponges. However, there are still limited sources of comprehensive reviews related to the relationship between the structure of isolated compounds and their cytotoxic activity. This review remarks the attempt to provide a preliminary guidance from the perspective of structure–activity relationship and its participation on marine natural products research. This guidance is segregated by the compound’s classes and their cytotoxic targets to obtain and organized a reliable summary of inter-study of the isolated compounds and their cytotoxicity. Structure–activity relationship is well-known for its ability to tune the bioactivity of a specific compound, especially on synthetic organic chemistry and in silico study but rarely used on natural product chemistry. The present review is intended to narrow down the endless possibilities of cytotoxicity by giving a predictable structure–activity relationship for active compounds. In addition, bioactive framework leads were selected by uncovering a noticeable structure–activity relationship with the intervention of cytotoxic agents from natural sources, especially Indonesian marine sponge.

show abstract

“…The ocean is rich in biodiversity, and many organisms have evolved unique morphological and physiological characteristics to adapt to challenging environments (Conte et al, 2021). Marine organisms further produce marine natural products (MNPs) with chemical diversity and interesting structures, including peptides, terpenoids, steroids, polyphenols, alkaloids, etc., (Sable et al, 2017;Murray et al, 2018;Wu et al, 2018;Carroll et al, 2019;Althagbi et al, 2020;Ermolenko et al, 2020). Currently, thousands of new MNPs are being reported every year (Carroll et al, 2020(Carroll et al, , 2021.…”

Section: Introductionmentioning

confidence: 99%

Advances in the Global Distribution, Chemical Constituents, and Pharmacology of Hippocampus, a Traditional Marine Chinese Medicine

Cui

Zhao

et al. 2021

Front. Mar. Sci.

View full text Add to dashboard Cite

Hippocampus is an important traditional marine Chinese medicinal resource that has been used to warm and tonify kidney yang in the clinic for a long time in China. Modern pharmacological studies show that its active ingredients display a wide range of pharmacological activities associated with the kidney, such as anti-inflammation, antioxidation, antitumor, and neuroprotective effects. Herein, we systematically summarize and analyze the research progress on the resource distribution, active ingredients, pharmacological activities, and clinical application of Hippocampus. First, the species and worldwide distribution of Hippocampus were assessed to clarify the existing resources, and the results showed that 44 species of Hippocampus have been found in 159 countries and regions worldwide. Then, based on the analysis of 16 kinds of active ingredients and extraction methods, the relationship between the ingredient extraction and pharmacological activities of Hippocampus was revealed. This review may provide a foundation for further research on the potential active ingredients and mechanisms of Hippocampus. In addition, the research status of traditional prescriptions containing Hippocampus was evaluated. The results implied that research on Hippocampus is still in its infancy, and the mechanism and material basis of its efficacy have not been clarified. This paper should provide directions for further studies on Hippocampus.

show abstract

Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity

Cited by 27 publications

References 132 publications

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

Structure–Activity Relationship of Cytotoxic Natural Products from Indonesian Marine Sponges

Advances in the Global Distribution, Chemical Constituents, and Pharmacology of Hippocampus, a Traditional Marine Chinese Medicine

Contact Info

Product

Resources

About