Marine guanidinium neurotoxins: Biogenic origins and interactions, biosynthesis and pharmacology

Cembella, Allan; Durán-Riveroll, Lorena M.

doi:10.1016/bs.ant.2021.05.001

Cited by 7 publications

(9 citation statements)

References 159 publications

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“…Globally, about half of the described Alexandrium species are known to produce PSTs, at least in certain strains and populations (Anderson et al, 2012;Cembella and Durán-Riveroll, 2021;Murray et al, 2021). For example, both toxic and nontoxic strains of A. minutum have been isolated from Irish coastal waters (Touzet et al, 2007).…”

Section: Toxigenicity Human Health and Environmental Consequencesmentioning

confidence: 99%

“…Paralytic shellfish toxins (PSTs) comprise a suite of >50 naturally occurring guanidinium neurotoxins, the most potent being carbamoyl derivatives, such as saxitoxin (STX) and neosaxitoxin (neoSTX) (reviewed in Cembella and Durán-Riveroll, 2021). These PSTs (or "saxitoxins") block conductance through sodium ion channels of nerve cells causing neuromuscular paralysis in vertebrates (Kao, 1993;Van Dolah, 2000;Durán-Riveroll et al, 2018) and in severe cases can cause death.…”

Section: Toxigenicity Human Health and Environmental Consequencesmentioning

confidence: 99%

“…Bioaccumulation of PSTs can occur in a wide diversity of marine organisms, directly by ingesting toxigenic dinoflagellates such as Alexandrium or via food web transfer, including mollusks, crustaceans, starfish, octopus, fish, turtles, marine mammals and sea birds (Cembella and Durán-Riveroll, 2021). Toxigenic Alexandrium blooms can also have severe impacts on marine ecosystems (Anderson, 1997;Llewellyn et al, 2006), causing localized disruption of ecosystem functioning and mortality of marine fauna via food web transfer.…”

Section: Toxigenicity Human Health and Environmental Consequencesmentioning

confidence: 99%

See 2 more Smart Citations

Apparent biogeographical trends in Alexandrium blooms for northern Europe: identifying links to climate change and effective adaptive actions

et al. 2022

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Section: Toxigenicity Human Health and Environmental Consequencesmentioning

confidence: 99%

Section: Toxigenicity Human Health and Environmental Consequencesmentioning

confidence: 99%

Section: Toxigenicity Human Health and Environmental Consequencesmentioning

confidence: 99%

See 1 more Smart Citation

Apparent biogeographical trends in Alexandrium blooms for northern Europe: identifying links to climate change and effective adaptive actions

et al. 2022

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“…42 Toxicity equivalency factors (TEFs) for these TTX analogues are essential for the evaluation of relative risk, but, unfortunately, information on the relative potencies of TTXs is limited. Although the use of different cell lines in toxicity assays has been questioned, it is evident that most analogues are much less toxic than TTX 43,44 Additionally, the parent TTX is usually the most abundant. 36 Bioassays, instrumental analysis, and immunological methods are typically employed to detect TTXs in field samples, based on the toxic effects, physicochemical properties, and antigenic specificity of the toxin, respectively.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Toxicity equivalency factors (TEFs) for these TTX analogues are essential for the evaluation of relative risk, but, unfortunately, information on the relative potencies of TTXs is limited. Although the use of different cell lines in toxicity assays has been questioned, it is evident that most analogues are much less toxic than TTX , Additionally, the parent TTX is usually the most abundant…”

Section: Introductionmentioning

confidence: 99%

Hybrid Antibody–Aptamer Assay for Detection of Tetrodotoxin in Pufferfish

et al. 2021

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The marine toxin tetrodotoxin (TTX) poses a great risk to public health safety due to its severe paralytic effects after ingestion. Seafood poisoning caused by the consumption of contaminated marine species like pufferfish due to its expansion to nonendemic areas has increased the need for fast and reliable detection of the toxin to effectively implement prevention strategies. Liquid chromatography-mass spectrometry is considered the most accurate method, although competitive immunoassays have also been reported. In this work, we sought to develop an aptamer-based assay for the rapid, sensitive, and cost-effective detection of TTX in pufferfish. Using capture-SELEX combined with next-generation sequencing, aptamers were identified, and their binding properties were evaluated. Finally, a highly sensitive and user-friendly hybrid antibody−aptamer sandwich assay was developed with superior performance compared to several assays reported in the literature and commercial immunoassay kits. The assay was successfully applied to the quantification of TTX in pufferfish extracts, and the results obtained correlated very well with a competitive magnetic bead-based immunoassay performed in parallel for comparison. This is one of the very few works reported in the literature of such hybrid assays for small-molecule analytes whose compatibility with field samples is also demonstrated.

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Development of a test strip for rapid detection of Gymnodinium catenatum

Fang

Liu

et al. 2022

Environ Monit Assess

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Harmful algal blooms (HABs) are major ecological and environmental problems in China's coastal waters and seriously threaten the stability of the marine ecosystem and human health. Gymnodinium catenatum is a toxic red tide dino agellate. It can produce paralytic shell sh toxins (PSP), which cause serious hazards to marine organisms, public health and safety. In this paper, a test strip based on colloidal gold immunochromatography (GICG) was developed for the rapid detection of Gymnodinium catenatum. The experimental results showed that the test trip has good speci city and sensitivity. It not only detects the different components of Gymnodinium catenatum but also may detect algal toxins. The lowest density of Gymnodinium catenatum that can be detected by this test strip is approximately 120 cells/mL. Crossreaction indicated that the test strip had a high speci city for Gymnodinium catenatum. This test strip provides a rapid method for on-site detection of Gymnodinium catenatum and a reference method for the monitoring of other harmful algae to serve as an early warning of upcoming red tides. It also provides a new way to prepare more detection methods for toxic algal toxins.

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Marine guanidinium neurotoxins: Biogenic origins and interactions, biosynthesis and pharmacology

Cited by 7 publications

References 159 publications

Apparent biogeographical trends in Alexandrium blooms for northern Europe: identifying links to climate change and effective adaptive actions

Apparent biogeographical trends in Alexandrium blooms for northern Europe: identifying links to climate change and effective adaptive actions

Hybrid Antibody–Aptamer Assay for Detection of Tetrodotoxin in Pufferfish

Development of a test strip for rapid detection of Gymnodinium catenatum

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