2017
DOI: 10.1016/j.marenvres.2016.05.002
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Marine microorganisms as a promising and sustainable source of bioactive molecules

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Cited by 159 publications
(113 citation statements)
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“…Illustrative of the importance of symbionts to marine drug discovery, some of these anti-tumorigenic compounds are now suspected to originate from the marine invertebrates symbiotic bacteria, rather than the host itself [8,19,34]. For example, this is true of the anti-tumorigenic drug Yondelis ® (Figrue 1), approved in 2007 for the treatment of ovarian cancer and tissue sarcomas [62].…”
Section: Yondelis ® Smenamides and Smenothiazoles: Compounds With mentioning
confidence: 99%
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“…Illustrative of the importance of symbionts to marine drug discovery, some of these anti-tumorigenic compounds are now suspected to originate from the marine invertebrates symbiotic bacteria, rather than the host itself [8,19,34]. For example, this is true of the anti-tumorigenic drug Yondelis ® (Figrue 1), approved in 2007 for the treatment of ovarian cancer and tissue sarcomas [62].…”
Section: Yondelis ® Smenamides and Smenothiazoles: Compounds With mentioning
confidence: 99%
“…Those microbes which have formed symbiotic relationships with a marine invertebrate, like a sponge or coral, have often developed further secondary metabolites, which also protect their hosts from pathogens [86,87]. This combination of self and host protection has selected for a huge range of secondary metabolites isolated from marine symbionts that are reported to have anti-microbial or anti-pathogenic properties [8,19].…”
Section: Yondelis ® Smenamides and Smenothiazoles: Compounds With mentioning
confidence: 99%
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“…It is imperative to obtain data on the distribution of fungi and actinobacteria from intertidal regions, due to environmental importance which occur natural and human disturbances induced moreover this microorganisms can hold great promise as biological control agents (Lira et al, 2006) and source of bioactive molecules (Romano et al, 2016;Alvarez et al, 2017). By the fact of them are exposed to high salinity, temperature, U.V.…”
Section: Isolation and Identification Of Filamentous Fungi And Actinomentioning
confidence: 99%
“…Actinobacteria exhibit various physiological and metabolic properties such as the production of extracellular enzymes further the formation of a wide variety of secondary metabolites including some antibiotics in use today are derived from natural actinobacteria and fungi products (Raju et al, 2010;Porsani, et al, 2013;Manivasagan et al, 2014;Sathiyanarayanan et al, 2014;Rashad et al, 2015;Romano et al, 2016;Dalitz, et al, 2016;Alvarez et al, 2017). In addition, different styles of life are found among actinobacteria thus this phylum includes pathogens (eg.…”
Section: Introductionmentioning
confidence: 99%