Marine n-3 Polyunsaturated Fatty Acids and Cellular Senescence Markers in Incident Kidney Transplant Recipients: The Omega-3 Fatty Acids in Renal Transplantation (ORENTRA) Randomized Clinical Trial

Chan, Joe; Eide, Ivar; Tannæs, Tone M.; Waldum-Grevbo, Bård; Jenssen, Trond; Svensson, My

doi:10.1016/j.xkme.2021.07.010

Cited by 6 publications

(5 citation statements)

References 49 publications

(122 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study is retrospective and the cohort studied is small and possibly statistically underpowered to detect all of the existing clinical associations of tubular cell senescence. In addition, all patients received RAAS and/or βblockers and many were also on treatment with statins, drugs which are known to possess a "senostatic" action, i.e., they can "downregulate" the senescent phenotype [31][32][33][34][35]. The stimulation of angiotensin type 1 (AT1) receptors, as well as of mineralocorticoid receptors, causes oxidative stress and vascular inflammation, which may lead to arterial stiffness and vascular aging [34,35].…”

Section: Discussionmentioning

confidence: 99%

SA-β-Gal in Kidney Tubules as a Predictor of Renal Outcome in Patients with Chronic Kidney Disease

Esposito,

Picciotto,

Verzola

et al. 2024

JCM

View full text Add to dashboard Cite

Cellular senescence has emerged as an important driver of aging and age-related disease in the kidney. The activity of β-galactosidase at pH 6 (SA-β-Gal) is a classic maker of senescence in cellular biology; however, the predictive role of kidney tissue SA-β-Gal on eGFR loss in chronic kidney disease (CKD) is still not understood. We retrospectively studied the expression of SA-β-Gal in kidney biopsies obtained in a cohort [n = 22] of incident patients who were followed up for 3 years as standard of care. SA-β-Gal staining was approximately fourfold higher in the tubular compartment of patients with CKD vs. controls [26.0 ± 9 vs. 7.4 ± 6% positive tubuli in patients vs. controls; p < 0.025]. Tubular expressions of SA-β-Gal, but not proteinuria, at the time of biopsy correlated with eGFR loss at the follow up; moreover, SA-β-Gal expression in more than 30% of kidney tubules was associated with fast progressive kidney disease. In conclusion, our study shows that SA-β-Gal is upregulated in the kidney tubular compartment of adult patients affected by CKD and suggests that tubular SA-β-Gal is associated with accelerated loss of renal function.

show abstract

Section: Discussionmentioning

confidence: 99%

SA-β-Gal in Kidney Tubules as a Predictor of Renal Outcome in Patients with Chronic Kidney Disease

Esposito,

Picciotto,

Verzola

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…Both drugs are known to posses a "senostatic" action, i.e. they can "downregulate" the senescent phenotype without removing senescent cells [30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Sa-β-Gal in Kidney Tubules as a Predictor of Renal Outcome in Patients with Chronic Kidney Disease

Esposito,

Picciotto,

Verzola

et al. 2023

Preprint

View full text Add to dashboard Cite

.Cellular senescence has emerged as an important driver of aging and age-related disease in the kidney. The activity of β-galactosidase at pH 6 (SA-β-Gal) is a classic maker of senescence in cellular biology. However the predictive role of kidney tissue SA-β-Gal on eGFR loss in chronic kidney disease (CKD) is still not understood. We retrospectively studied the expression of SA-β-Gal in kidney biopsies obtained in a cohort [n=29] of incident patients who were followed up for 3 years as for standard of care. SA-β-Gal staining was approximately 4-fold higher in the tubular compartment of patients with CKD vs. controls [26.0 ± 9 vs. 7.4 ± 6% positive tubuli in patients vs. controls; p < 0.025]. Tubular expressions of SA-β-Gal, but not proteinuria at the time of biopsy correlated with eGFR loss at follow-up; moreover, SA-β-Gal expression in more than 30% of kidney tubules was associated with fast progressive kidney disease. In summary, our study shows that SA-β-Gal is upregulated in the kidney tubular compartment of adult patients affected by CKD, and suggests that tubular SA-β-Gal is associated with accelerated loss of renal function.

show abstract

“…Nevertheless, the ratios between n-6/n-3 PUFAs might be able to modulate the composition of the senescent secretome in ways similar to those described for healthy cells, by entering different metabolic pathways. In recipients of kidney transplant, supplementation with marine n-3 PUFAs decreases plasma levels of multiple SASP factors including GCSF, IL1α, MMP-1 and MMP-13 [ 146 ]. n-3 PUFAS have been shown to limit the inflammatory responsiveness of macrophages by regulating the recruitment of Toll-like receptors to lipid rafts [ 147 , 148 ].…”

Section: Dietary Macronutrients In Longevity and Cellular Senescencementioning

confidence: 99%

The effects of macronutrients metabolism on cellular and organismal aging

Nehme¹,

Altulea²,

Gheorghe³

et al. 2023

Biomedical Journal

View full text Add to dashboard Cite

Marine n-3 Polyunsaturated Fatty Acids and Cellular Senescence Markers in Incident Kidney Transplant Recipients: The Omega-3 Fatty Acids in Renal Transplantation (ORENTRA) Randomized Clinical Trial

Cited by 6 publications

References 49 publications

SA-β-Gal in Kidney Tubules as a Predictor of Renal Outcome in Patients with Chronic Kidney Disease

SA-β-Gal in Kidney Tubules as a Predictor of Renal Outcome in Patients with Chronic Kidney Disease

Sa-β-Gal in Kidney Tubules as a Predictor of Renal Outcome in Patients with Chronic Kidney Disease

The effects of macronutrients metabolism on cellular and organismal aging

Contact Info

Product

Resources

About