Marine natural products as source of new drugs: an updated patent review (July 2018-July 2021)

Progress and Impact of Latin American Natural Product Databases

“…Over nearly four decades, they have been a significant resource of bioactive compounds for medicinal chemistry [ 3 ]. There are several sources for bioactive molecules, which include marine [ 4 , 5 ], fungal [ 6 , 7 ], bacteria [ 8 ], and plants [ 9 ]. Endogenous substances produced by humans and animals are another vital source of bioactive compounds [ 10 ].…”

Development of potent cholinesterase inhibitors based on a marine pharmacophore

“…2 Historically, the origin of the approved natural products has been terrestrial sources but with recent technological developments, the marine environment has started to significantly contribute with drug leads. 3,4 The oceans cover nearly 71% of our planet, and the marine environment represents a valuable source for providing an increasing number of bioactive compounds with molecular architectures able to bind to and modulate challenging targets. 5,6 We have just started to investigate the marine potential over the last 60 years and considering that less than 5% of the deep sea has been investigated, the ocean will continue to deliver novel and inspirational chemical scaffolds for the future.…”

“…5,6 We have just started to investigate the marine potential over the last 60 years and considering that less than 5% of the deep sea has been investigated, the ocean will continue to deliver novel and inspirational chemical scaffolds for the future. [7][8][9] As of July 2021, 15 compounds of marine origin have been approved as drugs 4,10 and 1407 new marine compounds were reported in 2020, mainly from fungi, sponges, cnidarians and bacteria. 6 In addition to uses for combatting infection and cancer, natural products play an important role for the management of different neurological disorders.…”

Progress and Impact of Latin American Natural Product Databases

“…Over the nearly four decades, they have been a significant resource of bioactive compounds for medicinal chemistry [3]. There are several sources for bioactive molecules, which include marine [4,5], fungal [6,7], bacteria [8], and plants [9]. Endogenous substances produced by humans and animals are another vital source of bioactive compounds [10].…”