Marine Natural Products, the Halogenated 1′-Methyl-1,2′-bipyrroles, Biomagnify in a Northwestern Atlantic Food Web

Pangallo, Kristin C.; Reddy, Christopher M.

doi:10.1021/es101039d

Cited by 21 publications

(23 citation statements)

References 49 publications

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“…Pangallo et al 51 suggested that MBPs may have an ocean-basin specific distribution, as evidenced by the dominance of brominated MBPs in the North Atlantic and highly-chlorinated derivatives in the South Pacific. The addition of our results, however, suggests a difference between the northern and southern hemisphere 52 , where SE Pacific and SW Atlantic odontocetes exhibit a dominance of chlorinated MBPs 48,49 and NE Pacific and NW Atlantic odontocetes exhibit a dominance of brominated MBPs 12,17,51,53 .…”

Section: Resultscontrasting

confidence: 63%

Nontargeted Screening of Halogenated Organic Compounds in Bottlenose Dolphins (Tursiops truncatus) from Rio de Janeiro, Brazil

Alonso

Maruya

Dodder

et al. 2017

Environ. Sci. Technol.

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To catalog the diversity and abundance of halogenated organic compounds (HOCs) accumulating in high trophic marine species from the southwestern Atlantic Ocean, tissue from bottlenose dolphins (Tursiops truncatus) stranded or incidentally captured along the coast of Rio de Janeiro, Brazil, were analyzed by a non-targeted approach based on GC×GC/TOF-MS. A total of 158 individual HOCs from 32 different structural classes were detected in the blubber of 4 adult male T. truncatus. Nearly 90 percent of the detected compounds are not routinely monitored in the environment. DDT-related and mirex/dechlorane-related compounds were the most abundant classes of anthropogenic origin. Methoxy-brominated diphenyl ethers and chlorinated methyl- and dimethyl bipyrroles (MBPs and DMBPs) were the most abundant natural products. Reported for the first time in southwestern Atlantic cetaceans and in contrast to North American marine mammals, chlorinated MBPs and DMBPs were more diverse and abundant than their brominated and/or mixed halogenated counterparts. HOC profiles in coastal T. tursiops from Brazil and California revealed a distinct difference, with a higher abundance of mirex/dechloranes and chlorinated bipyrroles in the Brazilian dolphins. Thirty-six percent of the detected HOCs had an unknown structure. These results suggest broad geographical differences in the patterns of bioaccumulative chemicals found in the marine environment, and indicate the need to develop more complete catalogs of HOCs from various marine environments.

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Section: Resultscontrasting

confidence: 63%

Nontargeted Screening of Halogenated Organic Compounds in Bottlenose Dolphins (Tursiops truncatus) from Rio de Janeiro, Brazil

Alonso

Maruya

Dodder

et al. 2017

Environ. Sci. Technol.

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“…HNP profiles have been shown to be unique to different marine species and ecotypes within a geographic region (Dorneles et al, 2010;Hauler et al, 2013;Pangallo and Reddy, 2010;Shaul et al, 2015). The species in this study displayed nearly unique HNP profiles ( Figure 3).…”

Section: Halogenated Natural Productsmentioning

confidence: 71%

“…The 30 identified halogenated natural products (HNPs) belonged to six different structural classes and accounted for 15% of the HOCs. These compounds are produced by algae or sponges and have a biomagnification potential similar to anthropogenic HOCs (Pangallo and Reddy, 2010). Despite their global distribution and profusion in marine food webs and biota, the health implications of exposure to HNPs are largely unknown (Shaul et al, 2015).…”

Section: Halogenated Natural Productsmentioning

confidence: 99%

Apex marine predators and ocean health: Proactive screening of halogenated organic contaminants reveals ecosystem indicator species

et al. 2019

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Despite decades-long bans on the production and use of certain chemicals, many halogenated organic compounds (HOCs) are persistent and can bioaccumulate in the marine environment with the potential to cause physiological harm to marine fauna. Highly lipid-rich tissue (e.g., marine mammal blubber) functions as a reservoir for HOCs, and selecting ideal indicator species is a priority for retrospective and proactive screening efforts. We selected five marine mammal species as possible indicators for the Southern California Bight (SCB) and applied a non-targeted analytical method paired with an automated data reduction strategy to catalog a broad range of known, known but unexpected, and unknown compounds in their blubber. A total of 194 HOCs were detected across the study species (n = 25 individuals), 81% of which are not routinely monitored, including 30 halogenated natural products and 45 compounds of unknown structure and origin. The cetacean species (long-beaked common dolphin, short-beaked common dolphin, and Risso's dolphin) averaged 128 HOCs, whereas pinnipeds (California sea lion and Pacific harbor seal) averaged 47 HOCs. We suspect this disparity can be attributed to differences in life history, foraging strategies, and/or enzyme-mediated metabolism. Our results support proposing (1) the long-and short-beaked common dolphin as apex marine predator sentinels for future and *

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“… 31 The modes by which DMBPs and MBPs enter the marine food web have not yet been identified, but MBPs have been shown to biomagnify with increasing trophic level. 62 There is evidence for biosynthesis of DMBPs by marine bacteria, 3 but further research is required to identify the sources and distribution in the Southern California Bight.…”

Section: Discussionmentioning

confidence: 99%

Nontargeted Biomonitoring of Halogenated Organic Compounds in Two Ecotypes of Bottlenose Dolphins (Tursiops truncatus) from the Southern California Bight

Shaul

Dodder

Aluwihare

et al. 2015

Environ. Sci. Technol.

173

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Targeted environmental monitoring reveals contamination by known chemicals, but may exclude potentially pervasive but unknown compounds. Marine mammals are sentinels of persistent and bioaccumulative contaminants due to their longevity and high trophic position. Using nontargeted analysis, we constructed a mass spectral library of 327 persistent and bioaccumulative compounds identified in blubber from two ecotypes of common bottlenose dolphins (Tursiops truncatus) sampled in the Southern California Bight. This library of halogenated organic compounds (HOCs) consisted of 180 anthropogenic contaminants, 41 natural products, 4 with mixed sources, 8 with unknown sources, and 94 with partial structural characterization and unknown sources. The abundance of compounds whose structures could not be fully elucidated highlights the prevalence of undiscovered HOCs accumulating in marine food webs. Eighty-six percent of the identified compounds are not currently monitored, including 133 known anthropogenic chemicals. Compounds related to dichlorodiphenyltrichloroethane (DDT) were the most abundant. Natural products were, in some cases, detected at abundances similar to anthropogenic compounds. The profile of naturally occurring HOCs differed between ecotypes, suggesting more abundant offshore sources of these compounds. This nontargeted analytical framework provided a comprehensive list of HOCs that may be characteristic of the region, and its application within monitoring surveys may suggest new chemicals for evaluation.

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Marine Natural Products, the Halogenated 1′-Methyl-1,2′-bipyrroles, Biomagnify in a Northwestern Atlantic Food Web

Cited by 21 publications

References 49 publications

Nontargeted Screening of Halogenated Organic Compounds in Bottlenose Dolphins (Tursiops truncatus) from Rio de Janeiro, Brazil

Nontargeted Screening of Halogenated Organic Compounds in Bottlenose Dolphins (Tursiops truncatus) from Rio de Janeiro, Brazil

Apex marine predators and ocean health: Proactive screening of halogenated organic contaminants reveals ecosystem indicator species

Nontargeted Biomonitoring of Halogenated Organic Compounds in Two Ecotypes of Bottlenose Dolphins (Tursiops truncatus) from the Southern California Bight

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