Marine omega-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behaviour and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD

Dervola, Kine S.N.; Roberg, Bjørg; Wøien, Grete; Bogen, Inger Lise; Sandvik, T.; Sagvolden, Terje; Drevon, Christian A.; Johansen, Espen Borgå; Walaas, S. Ivar

doi:10.1186/1744-9081-8-56

Cited by 37 publications

(34 citation statements)

References 75 publications

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“…Indeed, the ratios were strongly enhanced following exposure to PCB 153 in both male and female WKY as well as in male SHR, but no effects occurred in the female SHRs, indicating that the female SHR may represent a unique neurobiological phenotype regarding PCB exposure. In contrast, no changes were seen in the levels or dynamics of the measured amino acid transmitters (Dervola et al, 2012).…”

Section: Discussionmentioning

confidence: 77%

“…No significant changes occurred in either the levels (nmol/mg protein) or the turnover of the neurotransmitter amino acid levels (Dervola et al, 2012) between the genotypes or after exposure to PCB 153 (Table 1).…”

Section: Amino Acidsmentioning

confidence: 96%

“…The present study has investigated whether such PCB 153 exposure also led to differences in monoamine or amino acid transmitter dynamics in the brain. For this purpose, high performance liquid chromatography (HPLC) analysis was performed on extracts from the neostriatum in order to determine levels of neurotransmitters and their metabolites in a way which allowed us to calculate turnover ratios for, e.g., the monoamines DA and 5-HT as well as the amino acid transmitter Glu (Dervola et al, 2012). Moreover, a detailed immunochemical analysis of the proteins in nigrostriatal DA synapses in the PCB 153-exposed and control animals was performed.…”

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confidence: 99%

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Gender-dependent and genotype-sensitive monoaminergic changes induced by polychlorinated biphenyl 153 in the rat brain

et al. 2015

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Polychlorinated biphenyls (PCBs) are present as ortho- and non-ortho-substituted PCBs, with most of the ortho-substituted congeners being neurotoxic. The present study examined effects of the ortho-substituted PCB 153 on dopamine, serotonin and amino acid neurotransmitters in the neostriatum of both male and female Wistar Kyoto (WKY) and spontaneously hypertensive rat (SHR) genotypes. PCB 153 exposure at p8, p14 and p20 had no effects on levels of these transmitters when examined at p55, but led to increased levels of both homovanillic acid and 5-hydroxyindoleacetic acid, the degradation products of dopamine and serotonin, respectively, in all groups except the female SHR. Immunoblotting showed that PCB exposure induced gender-specific decreases in dopaminergic synaptic proteins. These included a novel finding of decreased levels of the dopamine D5 receptor in both genders and genotypes, whereas male-specific changes included decreases in the postsynaptic density (PSD)-95 protein in the WKY and SHRs and a decrease in the presynaptic dopamine transporter in both the WKY and, less clearly in the male SHR. A female-specific tendency of increased vesicular monoamine transporter-2 was observed in the SHRs after PCB exposure. No changes were seen in tyrosine hydroxylase, the cytoskeletal neurotubulin or the plasma membrane marker Na(+)/K(+)-ATPase in any strain. Hence, PCB-exposure led to increases in monoamine transmitter turnover in both male and female animals, whereas decreases in both pre- and postsynaptic dopaminergic proteins were predominantly seen in male animals. PCB 153 may therefore induce neostriatal toxicity through both presynaptic and postsynaptic mechanisms in both genotypes and genders, including effects on the aspiny interneurons, which employ the D5 receptor to mediate dopamine effects on interneurons in the basal ganglia.

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Section: Discussionmentioning

confidence: 77%

Section: Amino Acidsmentioning

confidence: 96%

mentioning

confidence: 99%

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Gender-dependent and genotype-sensitive monoaminergic changes induced by polychlorinated biphenyl 153 in the rat brain

et al. 2015

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“…A fish oil enriched diet was reported to reduce ambulatory activity in Wistar rats [28]. In SHRs, dams were given n-3 PUFA-enriched feed during pregnancy and their offspring continued on this diet [29]. This study showed an n-3 PUFA-induced reduction in spontaneous locomotion.…”

Section: Discussionmentioning

confidence: 67%

Dietary omega-3 fatty acids and locomotor activity in an animal model of attention deficit hyperactivity disorder (ADHD)

Lange

Makulska-Gertruda

Reisinger

et al. 2013

FFHD

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ABSTRACT:Background: Attention deficit hyperactivity disorder (ADHD) is the most frequent behavioral disorder of childhood and is characterized by hyperactivity, attention problems and impulsivity. Pharmacological and behavioral therapies have been shown to be effective. In addition, the role of dietary compounds in the etiology and possibly the treatment of ADHD has attracted increasing attention. For example, the lack of dietary essential fatty acids has been suggested to be associated with symptoms of ADHD in humans.Objective: To investigate the effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on locomotor activity in the spontaneously hypertensive rat (SHR) which has been proposed as an animal model of ADHD.Methods: Two groups of randomly assigned spontaneously hypertensive rats were fed with either n-3 PUFA-deficient or n-3 PUFA-enriched food (based on AIN93G) for six weeks and this was continued during the phase of behavioral testing. Locomotor activity was subsequently assessed using an open field test. Results:The results showed a marked difference in locomotor activity between the two groups of SHRs. In comparison with rats fed with n-3 deficient food, the animals on an n-3 enriched diet showed a statistically significant decrease in motor activity as assessed by the distance traveled. Conclusions:The present study demonstrates a marked reduction in locomotor activity following an n-3 PUFA-enriched diet in SHRs, i.e. the dietary enrichment with n-3 PUFAs reduced the motor activity in an established animal model of ADHD. Dietary n-3 PUFAs may therefore play a role in the pathophysiology of ADHD.

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“…Both of these results might me due to the fact that this group had maximum number of study as well as control subjects. Dervola et al, reported sex-specific changes in rat models of ADHD (more improvement in male rats) and attributed it to changes in presynaptic striatal monoamine and amino acid signaling [25].…”

Section: Discussionmentioning

confidence: 99%

Effect of Poly Unsaturated Fatty Acids Administration on Children with Attention Deficit Hyperactivity Disorder: A Randomized Controlled Trial

Anand

Sachdeva

2016

JCDR

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Marine omega-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behaviour and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD

Cited by 37 publications

References 75 publications

Gender-dependent and genotype-sensitive monoaminergic changes induced by polychlorinated biphenyl 153 in the rat brain

Gender-dependent and genotype-sensitive monoaminergic changes induced by polychlorinated biphenyl 153 in the rat brain

Dietary omega-3 fatty acids and locomotor activity in an animal model of attention deficit hyperactivity disorder (ADHD)

Effect of Poly Unsaturated Fatty Acids Administration on Children with Attention Deficit Hyperactivity Disorder: A Randomized Controlled Trial

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