Marine organisms as a source of new anticancer agents

Schwartsmann, Gilberto; Rocha, Adriana Brondani da; Berlinck, Roberto Gs; Jimeno, J.

doi:10.1016/s1470-2045(00)00292-8

Cited by 214 publications

(108 citation statements)

References 40 publications

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“…In xenograft models, aplidine showed activity against different tumour types (Albella et al, 2002). Results from early phase clinical trials have confirmed the reduced myelotoxicity of aplidine relative to didemnin B, and have shown activity against certain tumour types such as medullary thyroid carcinoma, renalcell carcinoma, melanoma and tumours of neuroendocrine origin (reviewed in Schwartsmann et al, 2001). …”

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confidence: 91%

Antiangiogenic activity of aplidine, a new agent of marine origin

et al. 2004

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The antineoplastic compound aplidine, a new marine-derived depsipeptide, has shown preclinical activity in vitro on haematological and solid tumour cell lines. It is currently in early phase clinical trials. The exact mechanism of action of this anticancer agent still needs to be clarified. We have previously reported that aplidine blocks the secretion of the angiogenic factor vascular endothelial growth factor (VEGF) by the human leukaemia cells MOLT-4, suggesting a possible effect on tumour angiogenesis. This study was designed to investigate the antiangiogenic effect of aplidine. In vivo, in the chick embryo allantoic membrane (CAM) assay, aplidine inhibited spontaneous angiogenesis, angiogenesis elicited by exogenous VEGF and FGF-2, and induced by VEGF overexpressing 1A9 ovarian carcinoma cells. In vitro, at concentrations achievable in the plasma of patients, aplidine inhibited endothelial cell functions related to angiogenesis. It affected VEGF-and FGF-2-induced endothelial cell proliferation, inhibited cell migration and invasiveness assessed in the Boyden chamber and blocked the production of matrix metalloproteinases (MMP-2 and MMP-9) by endothelial cells. Finally, aplidine prevented the formation of capillary-like structures by endothelial cells on Matrigel. These findings indicate that aplidine has antiangiogenic activity in vivo and inhibits endothelial cell functional responses to angiogenic stimuli in vitro. This effect might contribute to the antineoplastic activity of aplidine.

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confidence: 91%

Antiangiogenic activity of aplidine, a new agent of marine origin

et al. 2004

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“…Exploration of unscreened marine locality has led to the discovery of hundreds of biologically active compounds. Compared with terrestrial organisms, the secondary metabolites produced by marine organisms have broader bioactivities, more novel & unique structures owing to the complex living circumstance and diversity of species (Carte, 1996 andSchwartsmann et al, 2001). …”

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confidence: 99%

Evaluation of Antifungal, Hemolytic and Cytotoxic Potential of Ethyl Acetate Extract of a New Marine Streptomyces sp. AIAH-10

et al. 2016

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To face newly generated diseases, search for new, safe and effective bioactive molecules is highly warranted. The marine microbial flora may be a potential source of such molecules. The present study was designed to isolate marine microorganisms (AIAH-1 to AIAH-29) from the soil of mangrove forest Sundarbans, Bangladesh by serial dilution method using isolation media. Among them, AIAH-10 was selected for further study due to its promising antibacterial activity (done by streak plate and plug technique method) against a series of pathogenic bacteria. On the basis of morphological, cultural and biochemical analysis, the strain AIAH-10 belongs to Streptomyces sp. Secondary metabolites of the strain was obtained by small scale fermentation process. Antifungal activity of the extracts was performed by disc diffusion method. The crude ethyl acetate extract (50 g/disc) showed significant antifungal activity against Aspergillus niger, Candida albicans and Saccharromyces cerevaceae (14, 12 and 10 mm zone of inhibition respectively). No hemolytic activity was found of the extracts towards the human erythrocytes. During cytotoxic study against brine shrimp nauplii (Artemia salina), a dose dependent mortality rate was observed. A 100% larva mortality rate was recorded in 40 g/ml and more where as LC50 was found to be 6.61 g/ml.

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“…해조류는 단백질과 지방의 함량이 낮고 탄수화물의 함량이 높으며, 칼륨, 요오드, 칼슘 등의 각종 무기염류와 비타민 A, C 등의 함량이 높은 자원이며, 특히 갈조류는 alginate와 laminaran 및 fucoidan 등과 같이 인체에 유용한 다당류뿐만 아니 라 여러 생리활성물질을 함유하고 있다 [24,32]. 해조류의 다양 한 생리활성에 대한 연구들이 증가되고 있으며, 현재까지 알 려진 생리활성은 항산화 [17], 항암 [5], 항염증 [15], 항혈액응고 안전성 및 기능성 평가의 보고는 미흡한 실정이다 [9,34].…”

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Enhancement of Anti-inflammatory Activity by Fermentation of Sargassum siliquanstrum

이솔지¹,

이동근²,

김미향³

et al. 2016

Journal of Life Science

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This study was aimed to verify anti-inflammatory activity of fermented Sargassum siliquanstrum with lactic acid bacteria. Anti-inflammatory activities were compared by measuring the amount of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and suppressive effect on inducible nitric oxide synthase (iNOS) expression in stably transfected RAW 264.7 cells. Inhibitory activities of NO production and iNOS expression were measured after confirmation of NO radical scavenging activities. Fermentation increased NO radical scavenging activities from 7.6% to 15.2% compared to non-fermented condition, and fermentation with Lactobacillus sp. SH-1 was the most efficient. Fermentation without algal debris showed better NO radical scavenging activities than that with debris. Fermentation with Lactobacillus sp. SH-1 also showed the highest NO production inhibitory activity (64.1%) in LPS-stimulated RAW 264.7 cells. LPS-induced iNOS expression was diminished to 28.6, 35.6, 49.4 and 58.5 at 50, 100, 500 and 1,000 μg/ml, respectively, by fermentation with Lactobacillus sp. SH-1. According to MTT assay, fermented S. siliquanstrum did not influence the cell viability at all concentrations tested, meaning no or less cytotoxicity. These results suggest that S. siliquanstrum has NO radical scavenging activity and anti-inflammatory activity. Thus biological activities of S. siliquanstrum were upgraded by fermentation, which could be used for the development of functional foods.Key words : Anti-inflammatory, fermentation, immunity, nitric oxide, Sargassum siliquanstrum *Corresponding author *Tel : +82-51-999-5624, Fax : +82-51-999-5636 *E-mail : slee@silla.ac.kr This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Marine organisms as a source of new anticancer agents

Cited by 214 publications

References 40 publications

Antiangiogenic activity of aplidine, a new agent of marine origin

Antiangiogenic activity of aplidine, a new agent of marine origin

Evaluation of Antifungal, Hemolytic and Cytotoxic Potential of Ethyl Acetate Extract of a New Marine Streptomyces sp. AIAH-10

Enhancement of Anti-inflammatory Activity by Fermentation of Sargassum siliquanstrum

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