Marine pharmacology in 2007–8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action

Abstract

The peer-reviewed marine pharmacology literature in 2007-8 is covered in this review, which follows a similar format to the previous 1998-2006 reviews of this series. The preclinical pharmacology of structurally characterized marine compounds isolated from marine animals, algae, fungi and bacteria is discussed in a comprehensive manner. Antibacterial, anticoagulant, antifungal, antimalarial, antiprotozoal, antituberculosis and antiviral activities were reported for 74 marine natural products. Additionally, 59 marine compounds were reported to affect the cardiovascular, immune and nervous systems as well as to possess anti-inflammatory effects. Finally, 65 marine metabolites were shown to bind to a variety of receptors and miscellaneous molecular targets, and thus upon further completion of mechanism of action studies, will contribute to several pharmacological classes. Marine pharmacology research during 2007-8 remained a global enterprise, with researchers from 26 countries, and the United States, contributing to the preclinical pharmacology of 197 marine compounds which are part of the preclinical marine pharmaceuticals pipeline. Sustained preclinical research with marine natural products demonstrating novel pharmacological activities, will probably result in the expansion of the current marine pharmaceutical clinical pipeline, which currently consists of 13 marine natural products, analogs or derivatives targeting a limited number of disease categories.

Antibacterial Efficacy of Crude Extracts of Trichoderma Spp. Isolated From Mangrove Rhizosphere

“…Marine habitat represents an enormous resource for the discovery of potential therapeutic agents. Over the last several decades, numerous compounds have been found in marine organisms with interesting pharmaceutical activities 1 . Harsh and diverse marine environments lead to the growth of wide range organisms with potential chemical diversity.…”

Effectiveness of red alga Asparagopsis taxiformis extracts against Leishmania infantum

“…Among marine organisms, seaweeds produce a diverse array of novel secondary metabolites as a chemical defense strategy [35] and these are characterized by a broad spectrum of biological activities [6,10,11,[13][14][15]17,19,20,36].…”

Eksplorasi Karang Lunak Sebagai Antioksidan Di Pulau Pongok, Bangka Selatan

“…Distribusi karang lunak tersebar dari Afrika timur sampai barat Samudera Pasifik (Radjasa et al, 2007). Kelompok karang yang dapat memproduksi senyawa bioaktif adalah karang lunak yang mempunyai kemampuan sebagai antibakteria, antikanker, antibakteri, antifouling dan lain-lain (Mayer, 2010). Senyawa atau substansi kimia tersebut merupakan hasil metabolit sekunder organisme hidup yang sering dikenal dengan natural producty yang umumnya berupa terpenoid (Harper et al, 2001;Murniasih, 2005).…”