During the COVID-19, the relationships among family members and the stress that accompanied have increasingly affected families. The first aim of this study is to test the effects of marital adjustment, perceived stress and parental self-efficacy of married couples on family resilience during the COVID-19 pandemic. The second aim of this study is to investigate whether or not family resilience, perceived stress, parental self-efficacy and marital adjustment differentiate depending on demographic and other variables in the COVID-19 pandemic. Participants consisted of 241 married individuals with at least one child between 4 and 18 years old, and data were collected online. It was found that when perceived stress increased, parental self-efficacy and marital adjustment decreased; besides, this perceived stress indirectly influenced family resilience through parental self-efficacy and marital adjustment. Similarly, it was found that pregnant participants experienced higher level of perception of stress during the COVID-19 period. It was found that the family resilience of participants who got support within the family was higher than participants who got support from outside the family. However, no differences were found between males and females. In stressful processes like the COVID-19 pandemic, each sub-system of the family (individual, couple and parent) has a significant role in the resilience level of the family as a whole. Future studies focus on experimental and can focus on programs prepared for family resilience. Intervention programs can be prepared related to stress perception, parental skills and marital adjustment of married couples and their influence on family resilience can be searched.