Openness and communication between partners are key elements of dyadic coping with stress. Our main research question is: what is the impact of these factors on relational satisfaction in spouses struggling with infertility or miscarriage? In the current study, by applying the actor–partner interdependence model to 90 heterosexual couples (N = 180), we examined the link between the spouses’ openness (the Giessen Test), communication (Flexibility and Cohesion Evaluation Scales) and relationship satisfaction (the Marriage Success Scale). Controlling for relevant covariates (communication, own openness and type of stress experienced by the spouses: infertility or miscarriage), a dyadic analysis revealed significant actor (−0.24; p < 0.001) and partner effects (−0.20; p < 0.001). We conclude that the relationship between the perception of the partner’s openness and the relationship satisfaction in women is strong, in the context of the analyzed potential confounding variables. We also observe that the relationship satisfaction in women from the group of infertile spouses is 6.06 points lower compared to women from the group of marriages after miscarriage (p = 0.034).