Marjolin's ulcer: malignant neoplasm arising in scars

Ochenduszkiewicz, Urszula; Matkowski, Rafał; Szynglarewicz, B.; Kornafel, Jan

doi:10.1016/s1507-1367(06)71058-6

Cited by 21 publications

(28 citation statements)

References 12 publications

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“…Ochenduszkiewicz and coworkers noted that the prevalence of metastasis from MU was 30%. 6 Nodal metastasis was related to tumour grade rather than MU diameter.…”

Section: Discussionmentioning

confidence: 95%

Epidemiology and predictors of recurrence of Marjolin’s ulcer: experience from Mansoura Universityxs

Metwally

Roshdy

Saleh

et al. 2017

annals

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INTRODUCTION Marjolin's ulcer (MU) is an uncommon malignancy occurring on top of old scars. Once thought to be more common in Caucasians, is now detected increasingly in Africa. METHODS This was a retrospective study of patients with MU attending a tertiary centre within Mansoura University (Egypt) from 2004 to 2015. An institutional-based registry of skin and soft-tissue malignancies in this period revealed 560 cases, from which there were 26 cases of MU. RESULTS The most common underlying cause of MU was burns (92% of patients), followed by trauma. A predilection towards males was detected. The latent period was 4-70 (median, 25) years. Recurrence occurred in 12 cases, with multiple recurrences occurring in 5 cases. MU recurrence was noted as early as 3 months and as late as 25 years after surgery. CONCLUSIONS Young patients with MU are at higher risk of recurrence and should be followed up closely. A thorough search for nodal metastasis (especially in those with high-grade tumours) should be done. Wide local excision and leaving wounds to heal by secondary intention seems to be a viable treatment option.

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“…Ochenduszkiewicz and coworkers noted that the prevalence of metastasis from MU was 30%. 6 Nodal metastasis was related to tumour grade rather than MU diameter.…”

Section: Discussionmentioning

confidence: 95%

Epidemiology and predictors of recurrence of Marjolin’s ulcer: experience from Mansoura Universityxs

Metwally

Roshdy

Saleh

et al. 2017

annals

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“…In most cases, the MU is an SCC (71%), followed by BCC (12%), melanoma (6%), sarcoma (5%), squamobasal cell carcinoma (1%), SCC-melanoma (1%) and other rare neoplasms (4%) [2] . A variety of rare tumours may emerge in the post-burned wounds and scars and include fibrosarcoma, liposarcoma, dermatofibrosarcoma protuberans, and mesenchymal tumors [2,3,35,36] . The grade of the MU can be defined as follows: grade Ⅰ : more than 75% of the cells are differentiated; grade Ⅱ: 25%-75% of the cells are differentiated; grade Ⅲ: less than 25% of the cells are differentiated [10] .…”

Section: Histopathology Of Mumentioning

confidence: 99%

“…Lower limbs constitute the most frequent site of MUs. The other sites affected in order of reducing frequency include head and neck region (face, scalp, neck), upper limbs and other body parts [2,3,35] . MU has been reported in post burned scars at rare locations such as the nose [40] .…”

Section: Anatomic Sites Affected By Musmentioning

confidence: 99%

Marjolin’s ulcers in the post-burned lesions and scars

Saaiq

Ashraf

2014

WJCC

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Marjolin's ulcer (MU) represents malignant degeneration that typically ensues over a period of time in the post-burned lesions and scars or any other chronic wound. This review highlights various facets of the presentation and management of MUs that originate from post-burned lesions. The incidence of MUs in such lesions is reported to be 0.77%-2%. This malignancy characteristically develops in the areas of full thickness skin burns that had been allowed for weeks to months to heal spontaneously by secondary intention, or burn wounds which never healed completely over years and the unstable post-burned scars. In the majority of cases, the MU is a squamous cell carcinoma (SCC). The MUs contribute to an overall 2% of all SCCs and 0.03% of all basal cell carcinomas of the skin. Clinically MUs present in two major morphologic forms. The commoner form is the flat, indurated, ulcerative variety while the less common form is the exophytic papillary variety. Lower limbs represent the most frequently affected body parts. Surgical resection of the primary tumor with 2-4 cm horizontal clearance margin, nodal clearance and radiotherapy constitute the cornerstones of effective oncologic management. Despite best efforts, the overall mortality is reported to be 21%.

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“…The younger the patient is, the more likely he or she is to have a latency period of less than 1 year; older patients are increasingly likely to have a latency period greater than 1 year [10, 22, 23]. …”

Section: Discussionmentioning

confidence: 99%

“…A high index of suspicion should be considered in the presence of chronic ulcers persisting longer than 3 months; rolled or everted wound margins; foul-smelling discharge; and an increase in pain, ulcer size, or bleeding [7, 9, 18, 22, 24]. Biopsy of suspicious lesions for histopathology remains the gold standard for diagnosis [24].…”

Section: Discussionmentioning

confidence: 99%

Acute Marjolin’s Ulcer in a Postauricular Scar after Mastoidectomy

Alhysoni

Bukhari

Hajjaj

2016

Case Reports in Otolaryngology

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Background. Marjolin's ulcer is a rare, aggressive cutaneous malignancy that arises primarily in burn scars but can occur in other types of scars. Squamous cell carcinoma is the most common variant, and while malignant degeneration usually takes a long time, it can develop acutely. Case Report. a 30-year-old man who developed Marjolin's ulcer acutely in a right postauricular scar after mastoidectomy and the incision and drainage of a mastoid abscess. To the best of our knowledge, this report is the first to describe a Marjolin's ulcer in a postauricular surgical scar. However, it has been reported in others areas in the head and neck. Conclusion. Marjolin's ulcer is most commonly observed after postburn scars, but it may be observed after any type of scars, as our patient developed an SCC with a postsurgical scar. Early diagnosis is essential, and a biopsy should be performed on any nonhealing wound or chronic wound that undergoes a sudden change. Tissue samples should be taken from both the centre and the margins of the wound.

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Marjolin's ulcer: malignant neoplasm arising in scars

Cited by 21 publications

References 12 publications

Epidemiology and predictors of recurrence of Marjolin’s ulcer: experience from Mansoura Universityxs

Epidemiology and predictors of recurrence of Marjolin’s ulcer: experience from Mansoura Universityxs

Marjolin’s ulcers in the post-burned lesions and scars

Acute Marjolin’s Ulcer in a Postauricular Scar after Mastoidectomy

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