Marked decrease of tacrolimus blood concentration caused by compound Chinese herbal granules in a patient with refractory nephrotic syndrome

Yang, Peipei; He, Fan; Tan, Mei; Zhong, Fazhan; Liao, Xianghai; Li, Yingjie; Deng, Hui; Mo, Xiaolan

doi:10.1111/jcpt.13256

Cited by 5 publications

(6 citation statements)

References 21 publications

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“…Cohorts were well balanced in terms of the sex ratio in only four studies (CS 14,25,33,37) [46,49,64,69]. In other cases, patients were from only one sex, usually only male (CS 1, 6,12,16,19,21,24,26,27,28,29,30,32,35,36) but sometimes only female (CS 18,20,22,23,34) [47,52,59,61,71], or largely imbalanced. Men are over-represented in cohorts of herbal clinical studies in the last 10 years where women are known to be under-represented [79].…”

Section: Clinical Studiesmentioning

confidence: 98%

“…We analyzed 28 case reports from 2011 to 2021 (Table 1). Among the analyzed case reports, five described cases (CR 2,4,6,20,22) in which multiple herbs [18][19][20][21][22] were taken simultaneously, making any conclusion doubtful. This is certainly a problem as many commercial products contain a mixture of herbs in Western countries as in Asian countries.…”

Section: Case Reportsmentioning

confidence: 99%

“…The problem historically exists in traditional Chinese medicine (CR 2, 4, 22) [18,19,22], which is a non-negligible part of herbal medicine use and concerns three case reports in our corpus. A second problem with traditional medicine products is the lack of knowledge about the methods of preparation of the extracts consumed.…”

Section: Case Reportsmentioning

confidence: 99%

“…Thirteen studies investigated possible interactions involving food herbal supplements: ten clinical studies concerned Ayurvedic (CS 3) [55] and Asian medicines (CS 5,11,21,22,26,34,35,36,37) [56][57][58][59][60][61][62][63][64]. As previously mentioned, these therapies are characterized by the use of combinations of a large number of herbs and are thus too complex to be interpreted in terms of HDIs.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…Notably, patients undergoing chemotherapy are known to be large consumers of herbal products [66]. In nine of these studies, drugs are used as a probe with the goal to evaluate metabolic enzyme induction or inhibition as a primary endpoint (CS 1,4,14,15,20,22,24,36,37) [48,59,63,64,[67][68][69][70][71]. Probes are used as specific substrates of a given isoenzyme.…”

Section: Clinical Studiesmentioning

confidence: 99%

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HDI Highlighter, The First Intelligent Tool to Screen the Literature on Herb–Drug Interactions

2022

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Herbal food supplements are commonly used and can be an important part of patient self-care. Like all other bio-active and therapeutic products, they have a benefit/risk balance. These products are not without adverse effects and potentially interact with other therapies. Educating patients and providing information for health professionals about the risk of herb-drug interactions is key. One of the purposes of the biomedical literature is to inform prescribers. Scientific literature accessible on databases such as PubMed is dense and careful reading is time consuming. We propose a reading aid tool named "HDI highlighter" to help readers to find key information in clinical studies and case reports describing herb-drug interactions. It uses natural language processing algorithms (artificial intelligence) with a pharmaceutical focus. Semantic relation extraction for herb-drug interactions from the biomedical literature are overexpressed using keywords. We have tested it to review 120 published articles over the last 10 years. In these articles, we have shown that case reports often involved long-term or semi-long-term treatments such as cancer or human immunodeficiency virus therapies, antiepileptic drugs, or central nervous system drugs. Similarly, these classes of drugs are more extensively targeted by clinical studies. Herb-drug interactions described in case reports are identified in medicinal, recreational, and alimentary uses. They also usually lack a rigorous description of the herb(s) involved. Typically, clinical studies provide a complete description of protocols and dosages, with a few exceptions explained by patients' needs. Clinical studies on herbs are nevertheless conducted on a limited number of patients. All these limitations make the interpretation of herb-drug interactions complicated, but the HDI highlighter provides a quick overview of the herb-drug interaction literature.

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