Markedly elevated serum alkaline phosphatase level in an uncomplicated pregnancy

Celik, Handan; Tosun, Midraci; Çetinkaya, Mehmet; Bektab, Ahmet; Malatyalýodlu, Erdal

doi:10.1080/14767050802702323

Cited by 13 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acid phosphatase is a ubiquitous lysosomal enzyme that hydrolyzes organic phosphatases at an acidic pH [5]. On the other hand, alkaline phosphatases catalyze the hydrolysis of phosphate esters and it plays a significant role in transportation across cell membranes [29]. Both the enzymes are present in many tissues including bone, intestine, liver spleen kidney and WBCs [30].…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective effect of melatonin and L-Ascorbic acid (Vitamin-C) against ampicillin- induced toxicity in Funambulus pennanti

Rastogi

Gupta

Haldar

et al. 2020

Egyptian Journal of Basic and Applied Sciences

View full text Add to dashboard Cite

Ampicillin is one of the most commonly prescribed antibiotics against intrarenal infections. Prolonged use of ampicillin has been found to be associated with a high rate of free-radical generation and oxidative stress induced nephrotoxicity. In the present study, we report the comparative effects of melatonin and vitamin-C (Vit-C) in ameliorating the biochemical and structural alterations in renal tissues caused by ampicillin sodium. Biochemical parameters such as acid phosphatase (ACP), alkaline phosphatase (ALP), creatinine and urea levels in urine and serum as well as oxidative stress parameters such as superoxide dismutase (SOD) activity, catalase activity, total antioxidant status (TAS%) and lipid peroxidation in the renal cortical tissues were accessed upon treatment of melatonin and Vit-C following ampicillin sodium administration in Funambulus pennanti. Ampicillin treatment increased ACP, ALP, creatinine and urea levels in serum and urine, indicating renal damage. It also induced oxidative stress by increasing lipid peroxidation and decreasing the activity of antioxidative enzymes. However, the exogenous melatonin or Vit-C treatment inhibited ampicillin mediated renal damages. Melatonin or Vit-C pre-treatment significantly decreased ACP, ALP, creatinine, urea, TBARS level and increased SOD, catalase activity and TAS%. Our results suggest that the antibiotic induced nephrotoxicity can be ameliorated by melatonin or Vit-C via reduction of oxidative stress in renal tissues.

show abstract

Section: Discussionmentioning

confidence: 99%

Nephroprotective effect of melatonin and L-Ascorbic acid (Vitamin-C) against ampicillin- induced toxicity in Funambulus pennanti

Rastogi

Gupta

Haldar

et al. 2020

Egyptian Journal of Basic and Applied Sciences

View full text Add to dashboard Cite

show abstract

“…Alkaline phosphatases (ALP) are a group of enzymes that found in several body tissues such as liver, kidney, intestine, bone and white blood cells. The main function of alkaline phosphatase is transporting across the cell membranes (Celik et al, 2009). Hence, destruction of these tissues results in leakage of ALP into the blood.…”

Section: Discussionmentioning

confidence: 99%

Could Licorice prevent Bisphenol A-Induced Biochemical, Histopathological and Genetic Effects in the Adult Male Albino Rats?

Abdelzaher

Ali

Khalil

2018

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

View full text Add to dashboard Cite

Bisphenol A (BPA) is an ecological estrogenic endocrine disruptor used commonly in polycarbonate plastics. This study aimed to investigate the biochemical, histopathological and genetic effects of BPA at different doses and to evaluate the protective role of licorice against such effects. Thirty Wistar male albino rats were divided into five groups administered BPA daily at 2.4 µg/kg and 500 mg/kg orally with or without licorice (150 mg/kg) for 4 weeks. The results revealed that the high toxic dose decreased GSH, SOD and catalase levels and increased MDA level significantly. Serum TNF-α, testosterone and testicular cholesterol levels were significantly decreased while serum alkaline phosphatase was significantly increased. Histopathological changes were observed in testes, lungs and stomach. Alteration in the expression of NF-κB1 gene in lung occurred. These results suggested that BPA induced oxidative stress; resulted in its complication in the examined rats and treatment with licorice alleviated the toxicity induced by BPA.

show abstract

“…There were slow decline in the serum ALP levels following delivery in both cases, and this finding is similar to once case described by. 7,8 They discussed that a slow decline in the serum ALP level following delivery is a typical characteristic of placental isoenzymes. Among all the ALP isoenzymes, placental isoenzymes activity has the longest half-life of approximately 7days, followed by liver isoenzymes and the shortest half-life is bone isoenzymes, with half-life of 1-2days.…”

Section: Discussionmentioning

confidence: 99%

Extremely High Isolated Maternal Alkaline Phosphatase Serum Concentration -2 Case Reports

Yulia¹

2017

IPCB

View full text Add to dashboard Cite

Alkaline Phosphatase is a group of isoenzymes produced by liver, bones, kidneys, small intestine and placenta. It appears in maternal serum between the 15th and the 26th weeks and increases during the third trimester. Usually, ALP production in maternal serum is not major and total serum ALP level remains normal. Marked elevation of serum ALP may be caused by liver or bone pathology such as malignancy, extra hepatic biliary obstruction, and intrahepatic cholestasis. We report 2 cases of markedly elevated placental isoenzymes of ALP in the third trimester in otherwise uncomplicated pregnancies. In both cases, we have excluded liver, bone, kidney, thyroid, parathyroid, other immunological diseases, and other obstetrics complications. The serum ALP returned to normal level after delivery. We conclude that when markedly raised serum ALP concentration is present during pregnancy, differential diagnosis of other pathology must be excluded. Close monitoring of fetal and maternal conditions, histopathological examination of the placenta, and follow-up of declining ALP concentrations postnatally must be performed. As this condition may have high risk of recurrence in subsequent pregnancies, women should be managed in consultant led clinic.

show abstract

Markedly elevated serum alkaline phosphatase level in an uncomplicated pregnancy

Cited by 13 publications

References 10 publications

Nephroprotective effect of melatonin and L-Ascorbic acid (Vitamin-C) against ampicillin- induced toxicity in Funambulus pennanti

Nephroprotective effect of melatonin and L-Ascorbic acid (Vitamin-C) against ampicillin- induced toxicity in Funambulus pennanti

Could Licorice prevent Bisphenol A-Induced Biochemical, Histopathological and Genetic Effects in the Adult Male Albino Rats?

Extremely High Isolated Maternal Alkaline Phosphatase Serum Concentration -2 Case Reports

Contact Info

Product

Resources

About