Marker compound contents and antioxidant capacities of the taproot and lateral root of Danshen (<i>Salvia miltiorrhiza</i>Radix)

Seong, Gi-Un; Chung, Sung Kwang

doi:10.3839/jabc.2020.003

Cited by 3 publications

(2 citation statements)

References 28 publications

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“… a Tentative identification based on the measurement of the exact masses of the protonated [M+H] + or deprotonated [M−H] − molecules and their comparison with those reported for the genus Salvia [ 9 , 10 , 19 , 22 , 25 , 26 ]. b Tentative identification based on the study of the fragmentation pattern [ESI (+/−) —HRMS] and the isotopic ratio of the [M+H] + and [M−H] − ions and on the consultation of spectral databases [ 23 , 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…Standard substances allowed for the confirmatory identification of 14 compounds. A comparison of exact masses, the fragmentation patterns' isotopic ratios of characteristic ions, and retention times (elution order) with those reported in the scientific literature led to presumptive identifications [9,10,[18][19][20][21][22][23][24][25][26].…”

Section: Essential Oil Chemical Characterizationmentioning

confidence: 99%

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Chemical Composition and In Vitro Antioxidant Activity of Salvia aratocensis (Lamiaceae) Essential Oils and Extracts

et al. 2023

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Salvia aratocensis (Lamiaceae) is an endemic shrub from the Chicamocha River Canyon in Santander (Colombia). Its essential oil (EO) was distilled from the aerial parts of the plant via steam distillation and microwave-assisted hydrodistillation and analyzed using GC/MS and GC/FID. Hydroethanolic extracts were isolated from dry plants before distillation and from the residual plant material after distillation. The extracts were characterized via UHPLC-ESI(+/−)-Orbitrap-HRMS. The S. aratocensis essential oil was rich in oxygenated sesquiterpenes (60–69%) and presented τ-cadinol (44–48%) and 1,10-di-epi-cubenol (21–24%) as its major components. The in vitro antioxidant activity of the EOs, measured via an ABTS+• assay, was 32–49 μmol Trolox® g−1 and that measured using the ORAC assay was 1520–1610 μmol Trolox® g−1. Ursolic acid (28.9–39.8 mg g−1) and luteolin-7-O-glucuronide (1.16–25.3 mg g−1) were the major S. aratocensis extract constituents. The antioxidant activity of the S. aratocensis extract, obtained from undistilled plant material, was higher (82 ± 4 μmol Trolox® g−1, ABTS+•; 1300 ± 14 μmol Trolox® g−1, ORAC) than that of the extracts obtained from the residual plant material (51–73 μmol Trolox® g−1, ABTS+•; 752–1205 μmol Trolox® g−1, ORAC). S. aratocensis EO and extract had higher ORAC antioxidant capacity than the reference substances butyl hydroxy toluene (98 μmol Trolox® g−1) and α-tocopherol (450 μmol Trolox® g−1). S. aratocensis EOs and extracts have the potential to be used as natural antioxidants for cosmetics and pharmaceutical products.

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Section: Resultsmentioning

confidence: 99%

Section: Essential Oil Chemical Characterizationmentioning

confidence: 99%

Chemical Composition and In Vitro Antioxidant Activity of Salvia aratocensis (Lamiaceae) Essential Oils and Extracts

et al. 2023

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Comparison of quality characteristics of ‘Makgeolli’ made using brown and white rice of ‘Mirchal’

Seong¹,

Kang²,

Cho³

et al. 2021

Korean J. Food Preserv.

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In this study, we fermented ‘Makgeolli’ prepared using brown or white rice from ‘Mirchal’ for seven days to investigate the differences in their quality characteristics. Moreover, the physicochemical characteristics and antioxidant activities of ‘Makgeolli’ were assessed using principal component analysis (PCA). From the second day of fermentation, brown rice ‘Makgeolli’ exhibited a higher alcohol content (7.00%) than that of white rice ‘Makgeolli’ (3.60%). Additionally, the total polyphenol contents and antioxidant activities increased with the duration of fermentation (p<0.05) and were higher in brown rice ‘Makgeolli’ than those in white rice ‘Makgeolli’. Moreover, the proportion of glucose in the total free sugar content in brown rice ‘Makgeolli’ was 0.88, which was higher than that in the total free sugar content in white rice ‘Makgeolli’ (0.60). However, the levels of soluble solids, sugars, reducing sugars, and free sugars were higher in white rice ‘Makgeolli’ than those in brown rice ‘Makgeolli’. The PCA revealed that the quality characteristics of ‘Makgeolli’ prepared using brown or white rice were very distinct. Furthermore, the main contributing factor to these differences was the free sugar content. Moreover, the quality characteristics during fermentation were affected by the total acidity, polyphenol content, and alcohol content. This study provides useful data for processing ‘Makgeolli’ prepared using brown or white rice from ‘Mirchal’.

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Protective Effects of Active Compounds from Salviae miltiorrhizae Radix against Glutamate-Induced HT-22 Hippocampal Neuronal Cell Death

2020

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Oxidative stress is considered one of the factors that cause dysfunction and damage of neurons, causing diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), and Parkinson’s disease (PD).Recently, natural antioxidant sources have emerged as one of the main research areas for the discovery of potential neuroprotectants that can be used to treat neurological diseases. In this research, we assessed the neuroprotective effect of a 70% ethanol Salvia miltiorrhiza Radix (SMR) extract and five of its constituent compounds (tanshinone IIA, caffeic acid, salvianolic acid B, rosmarinic acid, and salvianic acid A) in HT-22 hippocampal cells. The experimental data showed that most samples were effective in attenuating the cytotoxicity caused by glutamate in HT-22 cells, except for rosmarinic acid and salvianolic acid B. Of the compounds tested, tanshinone IIA (TS-IIA) exerted the strongest effect in protecting HT-22 cells against glutamate neurotoxin. Treatment with 400 nM TS-IIA restored HT-22 cell viability almost completely. TS-IIA prevented glutamate-induced oxytosis by abating the accumulation of calcium influx, reactive oxygen species, and phosphorylation of mitogen-activated protein kinases. Moreover, TS-IIA inhibited glutamate-induced cytotoxicity by reducing the activation and phosphorylation of p53, as well as by stimulating Akt expression. This research suggested that TS-IIA is a potential neuroprotective component of SMR, with the ability to protect against neuronal cell death induced by excessive amounts of glutamate.

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Marker compound contents and antioxidant capacities of the taproot and lateral root of Danshen (Salvia miltiorrhizaRadix)

Cited by 3 publications

References 28 publications

Chemical Composition and In Vitro Antioxidant Activity of Salvia aratocensis (Lamiaceae) Essential Oils and Extracts

Chemical Composition and In Vitro Antioxidant Activity of Salvia aratocensis (Lamiaceae) Essential Oils and Extracts

Comparison of quality characteristics of ‘Makgeolli’ made using brown and white rice of ‘Mirchal’

Protective Effects of Active Compounds from Salviae miltiorrhizae Radix against Glutamate-Induced HT-22 Hippocampal Neuronal Cell Death

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