Markers of bone metabolism, serum leptin levels and bone mineral density in preterm babies

Veselá, Petra; Kaniok, Radek; Bayer, Milan

doi:10.1515/jpem-2013-0474

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…The development of adipose tissue in preterm infants may be delayed compared with in term infants, potentially resulting in leptin deficiency. Veselá et al (28) reported that the median cord blood concentration of leptin was 3.07 µg/l and the median cord blood concentration of leptin in infants at 32-33 weeks' gestation was 2.89 µg/l, which was lower than the 3.13 µg/l observed in preterm infants at 34-36 weeks' gestation. Nagasaki and Ohta (29) revealed that the median serum concentration of leptin at 33-38 weeks' gestation was 2.3 ng/ml (range: 1.0-3.9 ng/ml).…”

Section: Effects Of Leptin On Neurocognitive and Motor Functions In Jmentioning

confidence: 89%

Effects of leptin on neurocognitive and motor functions in juvenile rats in a preterm brain damage model

Feng

Jiang

2018

Mol Med Report

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Preterm infants face lifelong disabilities, including learning disorders, as well as visual, auditory and behavioral problems. Recent studies have demonstrated that leptin, an adipocytokine encoded by a gene associated with obesity and expressed in adipose tissue, affects neurocognitive and motor function; however, the mechanisms of brain damage in preterm infants are unclear. In the present study, the neuroprotective effects of leptin in a rat model of preterm hypoxic‑ischemic brain damage were investigated. Rats (2‑days‑old) were subjected to brain damage (ligation of the common carotid artery followed by exposure to 6% oxygen for 2 h) and treated with vehicle (control) or leptin. Spatial memory was analyzed in the present study using the Morris water maze test 19 days following ligation. Over the 24‑day post‑surgical observation period, capture‑resistance test, forelimb suspension and open field tests were conducted to evaluate motor function and anxiety‑associated behavior. Treatment with leptin did not affect survival rate or body weight. Treatment with leptin increased the number of platform crossings in rats with premature brain damage in the Morris water maze test, which was used to assess spatial memory. Multivariate analysis revealed that leptin reduced the latency to finding the platform location, independent of gender and weight. In the capture‑resistance, forelimb suspension and open field tests, there were no differences between animals administered leptin and the sham group. Collectively, the results of the present study suggested that leptin may alleviate spatial memory impairment resulting from premature brain damage, independent of gender or weight. These results may improve understanding of the neuroprotective effects exhibited by leptin in infants with preterm brain damage.

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Section: Effects Of Leptin On Neurocognitive and Motor Functions In Jmentioning

confidence: 89%

Effects of leptin on neurocognitive and motor functions in juvenile rats in a preterm brain damage model

Feng

Jiang

2018

Mol Med Report

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“…Data on this association in children are scarce, and current literature is inconclusive, with studies reporting positive, negative or no associations . In children born preterm (between 32 and 37 weeks of gestation), no relation was found between cord blood leptin and lumbar spine BMD at the age of 2 years . To our knowledge, no studies have investigated associations between leptin and bone metabolism in children born before 32 weeks of gestation.…”

Section: Introductionmentioning

confidence: 88%

Leptin and IGF‐1 in relation to body composition and bone mineralization of preterm‐born children from infancy to 8 years

Ruys

Lagemaat

Lafeber

et al. 2018

Clinical Endocrinology

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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Funding informationThe original randomized controlled trial was supported by an unrestricted research grant from Friesland Campina, Amersfoort, the Netherlands. Friesland Campina also provided the formulas. CR was supported by an unrestricted research grant, provided by Hero Benelux, Breda, the Netherlands. Neither Friesland Campina nor Hero Benelux had a role in the design and execution of the studies, or in the analysis and interpretation of the results. SummaryObjective: Preterm birth has been associated with altered body composition, especially increased fat mass (FM) and decreased bone mineralization, and leptin and IGF-1 have been suggested to be involved in the regulation of both. We aimed to study the interplay between leptin, IGF-1, FM and bone mineralization measured in infancy and childhood of children born preterm. Design: Observational study.Patients/subjects: Seventy-nine (40 boys) preterm-born children (gestational age ≤32 weeks and/or birth weight ≤1500 g) aged 8 years.Measurements: Serum leptin and IGF-1 were measured at term age, at 3-and 6-month corrected age (CA), and 8 years. Body composition (fat and lean mass) and bone parameters (bone area, mineral content and density) were measured by Dualenergy X-ray Absorptiometry (DXA) at term age, 6-month CA and 8 years.Results: Leptin was positively associated with FM at all time points and with bone parameters at term age and 6-month CA. IGF-1 was associated with body composition and bone density at most of the time points. Explained variation in bone mineralization increased significantly by adding bone area (BA) and height to the models. Conclusions:During infancy and childhood, leptin and IGF-1 were associated with body composition in preterm-born children. In addition, leptin was associated with bone parameters in early infancy, but not in childhood. It is hypothesized that a complicated interplay between multiple pathways, which most likely changes over time, is involved in regulation of body composition and bone mineralization of pretermborn infants. K E Y W O R D Sbone mineralization, fat mass, follow-up, IGF-1, leptin, preterm infants

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“…Like adiponectin, lower leptin levels were detected in premature infants at birth, with greater decreases in relation to lower GA [46]. However, this correlation may become inverted when levels are analyzed at later ages, probably influenced by the growth pattern and an increase in BMI [53] and the amount of fat mass [54].…”

Section: Discussionmentioning

confidence: 96%

“…Adipokines values may also differ by perinatal factors, such as weight and GA at birth [44,45]. Lower values of adiponectin, leptin and resistin were reported in infants born preterm [44,46], and in those small for gestational age [44,45], compared with full-term infants and newborns adequate for gestational age (AGA). However, adipokine research beyond birth in premature children and its link to early postnatal growth is scarce and controversial.…”

Section: Discussionmentioning

confidence: 99%

Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction

et al. 2020

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Adipose tissue programming could be developed in very preterm infants with extrauterine growth restriction (EUGR), with an adverse impact on long-term metabolic status, as was studied in intrauterine growth restriction patterns. The aim of this cohort study was to evaluate the difference in levels of plasma adipokines in children with a history of EUGR. A total of 211 school age prepubertal children were examined: 38 with a history of prematurity and EUGR (EUGR), 50 with a history of prematurity with adequate growth (PREM), and 123 healthy children born at term. Anthropometric parameters, blood pressure, metabolic markers and adipokines (adiponectin, resistin, leptin) were measured. Children with a history of EUGR showed lower values of adiponectin (μg/mL) compared with the other two groups: (EUGR: 10.6 vs. PREM: 17.7, p < 0.001; vs. CONTROL: 25.7, p = 0.004) and higher levels of resistin (ng/mL) (EUGR: 19.2 vs. PREM: 16.3, p =0.007; vs. CONTROL: 7.1, p < 0.001. The PREM group showed the highest values of leptin (ng/mL), compared with the others: PREM: 4.9 vs. EUGR: 2.1, p = 0.048; vs. CONTROL: 3.2, p = 0.029). In conclusion, EUGR in premature children could lead to a distinctive adipokines profile, likely associated with an early programming of the adipose tissue, and likely to increase the risk of adverse health outcomes later in life.

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Markers of bone metabolism, serum leptin levels and bone mineral density in preterm babies

Cited by 7 publications

References 22 publications

Effects of leptin on neurocognitive and motor functions in juvenile rats in a preterm brain damage model

Effects of leptin on neurocognitive and motor functions in juvenile rats in a preterm brain damage model

Leptin and IGF‐1 in relation to body composition and bone mineralization of preterm‐born children from infancy to 8 years

Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction

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