Markers of bone remodeling in neoplastic and bone-related lesions

Abstract

Our data indicate that the bone resorption markers are more highly expressed in OF, CGCL, and OS than in FD and SBC, indicating a significant association between these proteins and the clinical behavior of these lesions.

Histomorphometrical and molecular evaluation of endosseous dental implants sites in humans: correlation with clinical and radiographic aspects

“…In contrast to our results, a recent study developed by some members of our research team (Elias et al. ) found an imbalance in RANK‐RANKL‐OPG and OC in fibrous‐osseous lesions. These authors reported lower expression of RANKL and higher expression of OPG and OC in fibrous dysplasia, demonstrating that there is decreased bone resorptive activity in this lesion.…”

“…Although a recent study demonstrated that the RANK‐RANKL‐OPG system is imbalanced in fibro‐osseous lesions (Elias et al. ), the expression of these molecules in different “normal” bone patterns remains to be elucidated. However, we hypothesize that these proteins involved in bone metabolism may influence the bone microarchitecture, which in turn could be associated with different bone‐type classification systems.…”

Glucocorticoids, calcitonin, and osteocalcin cannot differentiate between aggressive and nonaggressive central giant cell lesions of the jaws

“…Park et al 34 and Elias et al 33 described the same expression pattern in previous studies, although these authors did not describe the aggressiveness of the cases studied. The reduced expression of OC in the cells of CGCLs may be related to the high osteolytic potential of the lesions.…”

“…6,30 Previous studies have demonstrated that the bone resorption process in CGCL is similar to that which occurs in normal bone tissue. [31][32][33] The bone resorption process in CGCL is well documented in the literature [31][32][33] ; however, only a few studies have evaluated the osteogenic profile and bone formation capacity of this lesion. 33,34 Osteocalcin (OC) is a protein secreted by osteoblasts and can be used as a marker of bone formation and osteoblastic activity.…”

“…[31][32][33] The bone resorption process in CGCL is well documented in the literature [31][32][33] ; however, only a few studies have evaluated the osteogenic profile and bone formation capacity of this lesion. 33,34 Osteocalcin (OC) is a protein secreted by osteoblasts and can be used as a marker of bone formation and osteoblastic activity. 35 CGCLs express little to no OC, 33,34 but a comparative evaluation between the CGCL variants has not been made.…”