Markers of Immune Regulation in Children Exposured to Aluminum

Dolgikh, O.V.; Starkova, K. G.; Alikina, I. N.; Chelakova, Yu. A.; Otavina, E. A.; Nikonoshina, N. A.

doi:10.17072/1994-9952-2019-1-96-100

Cited by 3 publications

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“…The advertising text has a significant influence on the formation of values and patterns of behavior in society. Currently, advertising is not only the dissemination of commercial information about a product or service; it is an instrument through which one can influence the socio-cultural, educational and aesthetic spheres [5].…”

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confidence: 99%

Reflection of national and cultural specifics in the text of advertising (on material of texts of advertising of the Chinese and Russian building companies)

Araeva

Guo

2018

MATEC Web Conf.

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The purpose of article is detection of the general and specific advertising texts of real estate development companies in slogans in the Russian and Chinese languages. Any advertising is designed for the consumer who will buy the advertised goods. The scientific novelty of the study is determined by the fact that for the first time a propositional analysis of the “advertisement” frame in Chinese, which is an isolating one, is carried out. This approach is based on the technique of frame modeling, where the main components are the deep structures of knowledge propositional schemes and verbal propositions. Advertising efficiency is caused by the accounting of the traditions which developed in a certain nation, stereotypes and those associations which invisibly are present at texts. The phraseological units functioning in this or that culture are created on the basis of these traditions, cultural stereotypes; reflect features of a world view of the nation. The conducted research allows revealing that at the heart of phraseological units there are same propositional structures which are invisibly sending a thought of the person to propositions. The person learns the world, comparing one to another. It is propositional organized phraseological units allow to reveal the associations, general and unique for the nation. On the one hand, to understand that, at the most abstract level all languages are arranged equally what Humboldt wrote about, and, with another – to see an originality of each language.

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Section: Introductionmentioning

confidence: 99%

Reflection of national and cultural specifics in the text of advertising (on material of texts of advertising of the Chinese and Russian building companies)

Araeva

Guo

2018

MATEC Web Conf.

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“…Стоит отметить, что иммунотоксические свойства бенз(а)пирена ранее подробно описаны в обсервационных и экспериментальных исследованиях [10,18,19], однако в литературе нет сведений о модификации его действия в условиях воздействия дополнительных стрессовых факторов -низкой температуры и особого светового режима. Также имеются отдельные отечественные работы о нарушениях иммунного профиля в экстремальных климатогеографических условиях Арктической зоны, однако они затрагивают преимущественно взрослый контингент -местное население и вахтовых рабочих [9,20], в то время как особенности иммунного статуса детского населения северных территорий остаются менее изученными.…”

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The risk of imbalance in the population composition of lymphocytes and specific sensitization in children living under exposure to airborne benzo(a)pyrene in the Arctic zone of Russia

Dolgikh,

Nikonoshina

2023

Health Risk Analysis

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Climatic and geographical determinants of the Arctic zone can aggravate effects of technogenic chemical factors and induce health disorders in children even at low exposure levels. 1291 children aged 3–6 years were examined. Group A included 608 children living in an urbanized area in the Arctic zone. Group B consisted of 204 children from a conventionally clean area of the Arctic zone. Group C included 308 children from an urbanized middle latitude area. Group D consisted of 171 children from a conventionally clean middle latitude area. Benzo(a)pyrene levels in ambient air and in blood were determined by HPLC. Identification of T-(CD3+) and B-lymphocytes (CD19+) was carried out by flow cytofluorometry. Exposure to airborne benzo(a)pyrene (0.6 average daily MPL) in the Arctic zone in a daily dose equal to 7.11•10-3 µg/(kg•day) results in blood of exposed children being contaminated with benzo(a)pyrene and in lower levels of Т-lymphocytes (СD3+) (OR (CI) = 2.99 (2.00–4.46); RR (CI) = 1.94 (1.47–2.56); p = 0.024) against hyperexpression of B-lymphocytes (CD19+) (OR (CI) = 2.55 (1.83–3.56); RR (CI) = 1.68 (1.36–2.06); p = 0.019) and IgG to benzo(a)pyrene (OR (CI) = 53.33 (27.56–103.20); RR (CI) = 15.11 (8,24–27.72); p = 0.001) in comparison with children living on a conventionally clean territory (p < 0.05). Similar disorders are identified in children in case benzo(a)pyrene is introduced in a dose equal to 87.6•10-3 µg/(kg•day) under airborne exposure (7.4 average daily MPL) in the middle-latitude zone (p > 0.05). Thus, children who live in the Arctic zone and are exposed to airborne benzo(a)pyrene in an average daily dose equal to 7.11•10-3 µg/(kg•day) face an elevated risk of imbalance in the population composition of lymphocytes as per basic cell differentiation clusters (CD3+ and CD19+; RR = 1.68–1.94; p = 0.024–0.019) and specific sensitization (IgG to benzo(a)pyrene; RR = 15.11; p = 0.001). This risk is comparable with effects of exposure to airborne benzo(a)pyrene in an average daily dose equal to 87.6•10-3 µg/(kg•day) in the middle-latitude zone. These findings confirm the hypothesis on effects of technogenic chemical factors being potentiated by specific climatic and geographic conditions (low average annual temperatures and photoperiodic asymmetry). Their additive effects induce early manifestations of pathological phenotypic health disorders in children even under low levels of exposure to benzo(a)pyrene.

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Immune and neurohumoral profile of the children population living in the conditions of exposure to benzo(a)pyrene

Nikonoshina

Dolgikh

2023

Hygiene and Sanitation

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Introduction. Benzo(a)pyrene induces disorders of immune and neurohumoral regulation that are aggravated by the influence of unfavourable climatic and geographical factors in the Far North. In this regard, studies of the features of the immune and neurohumoral profile are of particular relevance for the identification of markers of early health disorders of the population of industrially developed circumpolar territories (using the example of benzo(a)pyrene). Materials and methods. Five hundred 3-6 year children living in the circumpolar territory of Eastern Siberia were examined. Observation group consisted of 352 children living in conditions of exposure to benzo(a)pyrene. Comparison group included 148 children residing at a relatively clean territory. Determination of the content of benzo(a)pyrene in the blood was carried out by HPLC. Phenotyping of CD3+-, CD19+-, CD3+CD95+-, Annexin V-FITC+7AAD- and Annexin V-FITC+7AAD+-lymphocytes was performed by flow cytofluorometry. The level of IgA, IgM, IgG was determined by Mancini radial immunodiffusion, the IgG content to benzo(a)pyrene was determined by allergosorbent testing. The content of acetylcholine, serotonin, and neurotropin-3 was determined by ELISA. Results. Children living in the industrially developed circumpolar territory of Eastern Siberia have an increased level of blood contamination with benzo(a)pyrene (p<0.05). The immune profile is characterized by inhibition of cellular (CD3+ deficiency) and humoral immunity (decreased IgA, IgM, IgG with an excess of CD19+). Violations of apoptosis (decrease in Annexin V-FITC+7AAD-, Annexin V-FITC+7AAD+-lymphocytes; increase in Bcl-2 and CD95+) were revealed (p<0.05). An increased IgG to benz(a)pyrene content were found (p<0.05). The neurohumoral profile of the examined children is characterized by hyperexpression of serotonin with acetylcholine and neurotropin-3 deficiency (p<0.05). Limitations. The results of the study are intended for specialists in the field of hygiene, immunology and allergology. Conclusion. Revealed features of the immune status (deficiency of CD3+, Annexin V-FITC+7AAD-, and Annexin V-FITC+7AAD+-lymphocytes IgA, IgM, IgG, excess CD19+, CD95+, Bcl-2, IgG to benzo(a)pyrene), associated with changes in sympathetic-parasympathetic balance (excess serotonin, deficiency of acetylcholine, neurotropin-3) characterize the features of the immune and neurohumoral profile in the children population of the circumpolar territories of Eastern Siberia under the conditions of exposure to benzo(a)pyrene.

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Markers of Immune Regulation in Children Exposured to Aluminum

Cited by 3 publications

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Reflection of national and cultural specifics in the text of advertising (on material of texts of advertising of the Chinese and Russian building companies)

Reflection of national and cultural specifics in the text of advertising (on material of texts of advertising of the Chinese and Russian building companies)

The risk of imbalance in the population composition of lymphocytes and specific sensitization in children living under exposure to airborne benzo(a)pyrene in the Arctic zone of Russia

Immune and neurohumoral profile of the children population living in the conditions of exposure to benzo(a)pyrene

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