Markers of inflammation before and after curative ablation of atrial flutter

Abstract

CRP and IL-6 levels are elevated in patients presenting in AFL. Given the lower CS values in these patients, their origin appears to be systemic rather than cardiac. Because these levels significantly fall after ablation of AFL, the atrial tachyarrhythmia appears to be the cause (not the effect) of the inflammation.

EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication

“…The relationship between IL-6 and AF may be mediated by left atrial enlargement. 269 While evidence that inflammatory markers presage the development of AF has been replicated, 268,274 there are also multiple studies to demonstrate that atrial arrhythmias likely contribute to inflammation: specifically, cardioversion of AF 275 as well as ablation of either AF 276 or atrial flutter 277 has resulted in a decrease in inflammation. Indeed, Marcus et al demonstrated that the rhythm at the time of the blood draw (AF vs. sinus) was an important determinant in detecting an elevated CRP or IL-6 level.…”

The importance of the mean platelet volume in the diagnosis of supraventricular tachycardia

“…Fustaci et al demonstrated that marked inflammatory infiltrates in the atrial biopsies of patients with lone AF 17 . Additionally, previous studies concluded a decrease in inflammation after cure of atrial arrhythmias 15,18 . The results of all these previous studies suggested that atrial tachyarrhythmia's may be responsible for or at least stimulate a systemic inflammatory process.…”

“…The literature contains only limited data from small-scale studies assessing the diagnostic values of biomarkers in patients presenting to the ED with SVT [12][13][14] . Previous studies concluded that inflammation may play an important role in SVT 15,16 . Chung et all concluded that an elevated inflammation markers (specially Creactive protein) may predict atrial tachycardia's in some patients.…”

“…The diagnosis of palpitation can be difficult in the ED and the waiting time for a first appointment with an arrhythmia clinic can be very long. Previous studies have shown that inflammation is sufficient to facilitate the initiation of SVT, and recent evidence has demonstrated that an elevated inflammation markers may predict atrial tachycardia's in some patients [1][2][3] . The mean platelet volume (MPV) is potentially one of the most important biomarkers of platelet activity and calculated by automatic blood count equipment during routine blood counts 4 .…”

Novel Index for Determining the Development of Electrophysiological and Structural Atrial Remodeling in Patient with Atrial Fibrillation

“…The patients medicated with statins tended to include younger patients, whereas those medicated with ACE-Is or AII antagonists tended to include older patients with hypertension or a reduced ventricular function; which may have modified the results of the analysis of our data. Recent clinical studies have demonstrated that the CRP level is transiently elevated after CA (Marcus et al 2008), and that the short-term AF episodes were transiently increased (Oral et al 2002). These reports also suggested that the increased inflammatory response from the CA procedure may increase the following transient occurrences of AF.…”