2013
DOI: 10.1155/2013/378790
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Markers of Oxidative Stress during Diabetes Mellitus

Abstract: The prevalence of diabetes mellitus is rising all over the world. Uncontrolled state of hyperglycemia due to defects in insulin secretion/action leads to a variety of complications including peripheral vascular diseases, nephropathy, neuropathy, retinopathy, morbidity, and/or mortality. Large body of evidence suggests major role of reactive oxygen species/oxidative stress in development and progression of diabetic complications. In the present paper, we have discussed the recent researches on the biomarkers of… Show more

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Cited by 423 publications
(338 citation statements)
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References 99 publications
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“…22 These changes reflect oxidative stress which may be mirror a decreased antioxidant defense potential. 23 In this study sciatic nerve from untreated diabetic rats showed fewer number of dispersed nerve fibers with smaller diameter with some degenerated axons and dilated myelin sheaths. Some Schwann cells were degenerated.…”
Section: Figure (2)mentioning
confidence: 52%
“…22 These changes reflect oxidative stress which may be mirror a decreased antioxidant defense potential. 23 In this study sciatic nerve from untreated diabetic rats showed fewer number of dispersed nerve fibers with smaller diameter with some degenerated axons and dilated myelin sheaths. Some Schwann cells were degenerated.…”
Section: Figure (2)mentioning
confidence: 52%
“…The association between the levels of TBARS and AOPPs during DM indicates that proteins are likewise targeted by ROS as the lipids (2). Taking into account the importance of controlling DM complications, preventing oxidative damage is fundamental since the oxidation of proteins affects many physiological functions.…”
Section: Discussionmentioning
confidence: 99%
“…The genesis of DM can occur due to defects in insulin secretion by the pancreas, defects in insulin's target cells (insulinformation of other reactive oxygen (ROS) and nitrogen (RNS) species (5). Lipid peroxidation, protein oxidation, damage to deoxyribonucleic acid (DNA), and the irreversible formation of AGEs caused by ROS are exacerbated due to the decrease in an antioxidant defense with a marked reduction of glutathione (GSH) (2,4).…”
Section: Iabetes Mellitus (Dm) Is a Group Of Endocrinementioning
confidence: 99%
See 1 more Smart Citation
“…Hyperglycemia also causes tissue damage through different mechanisms, including increased intracellular formation of advanced glycation end products (AGEs), increased expression of the receptor for AGEs, activation of protein kinase C isoforms etc. (2,3). According to the International Diabetes Federation, it is estimated that 415 million people of the world's population were suffering from DM in 2015 and it is expected to show a steady growth of 642 million by the year of 2040 (4).…”
Section: Introductionmentioning
confidence: 99%