Markers of Undifferentiated Connective Tissue Dysplasia in Female Patients with Acute Q-myocardial Infarction

Abstract

Myocardial infarction (MI) remains the leading cause of death in patients with coronary heart disease (СHD) worldwide. Over the past twenty years, there has been a tendency to increase the prevalence of congenital disorders of connective tissue. The relevance of this problem is due not only to the growing occurrence of undifferentiated connective tissue dysplasia (UCTD) and a variety of complications but also to medical and social problems resulting from associated somatic diseases. Considering the high social significance of the problem of CHD on the background of UCTD, and because it affects mainly people of working age, this study aimed to investigate stigmas of dysplasia in women with Q-MI on the background of UCTD. The most common stigmas of dysembryogenesis in patients with UCTD were various anomalies of the hands and feet (100%), ophthalmic stigmas and microanomalies of the auricles (90% each), varicose veins of the lower extremities (33.3%) and easy formation of hematomas at insignificant damage (20%). Correlations were found in women with UCTD between the number of markers and the frequency of detection of the diagonal fold of the earlobe (r=+0.79; p<0.05), blue sclera (r=+0.77; p<0.05), radial-lacunar type of iris (r=+0.66; p<0.05), varicose veins of the lower extremities (r=+0.73; p<0.05) and easy formation of hematomas at insignificant damage (r=+0.51; p<0.05). Thus, the above markers of UCTD can be considered as prognostic criteria for the complicated course of CHD, which will allow further development of new approaches to the detection of such individuals and their differentiated therapy.

Q-myocardial Infarction on the Background of Undifferentiated Connective Tissue Dysplasia: Pathogenetic &ldquo;Paradoxes&rdquo; and &ldquo;Crossovers&rdquo;

“…It should be noted that such phenotypic (radial-lacunar iris of the eye (30 patients, 66.7%), blue sclera (30 people, 66.7%), anomalies of the auricles (41 patients, 91.1%), predisposition to early caries (20 subjects, 44.4%), medial/lateral clinodactyly (39 subjects, 86.8%)) and visceral (varicose veins of the lower extremities (15 patients, 33.3%), mild hematoma formation with insignificant damage (10 people, 22.2%)) UCTD stigmas were detected significantly more often in the main group than in the comparison group (p<0.05). The obtained data are consistent with the results of other authors and our studies conducted on another cohort of patients [9,10,13,16].…”

“…Verification of the diagnosis of Q-MI has been performed based on a positive result of the troponin test and elevated levels of cardio-specific enzymes in the presence of pain and relevant ECG changes, taking into account international standard criteria [10] and according to medical care protocol for patients with acute coronary syndrome [12].…”

“…The number of phenotypic and visceral stigmas of UCTD was counted, based on examination. The diagnosis of UCTD was established by detecting 6 or more positions of microanomalies [10]. • Somatometric examination (analysis of the following anthropometric features by the method of Bunak modified by Shaparenko [14], such as body weight, body length, torso length, neck length, chest-length, lower length limbs, head circumference, chest circumference) [9].…”

“…Due to the prevalence of UCTD among people of working age in the general population (particularly more than 50% of the population in environmentally unfavorable regions of Eastern Europe), the investigation of the biochemical properties of Q-IM in UCTD is relevant [9,10]. Although cardiovascular markers of UCTD are currently well studied, some authors note changes in blood cells (the liquid form of connective tissue), particularly platelets, in people with UCTD [9,11].…”

Integrative Art-therapeutic Correction of Psychosomatic Disorders in Children with Undifferentiated Connective Tissue Dysplasia

“…The analysis of recent scientific works reveals the growth of studies devoted to syndromal pathology, the basis of which is connective tissue dysplasia [1][2][3]. The relevance of this pathology is determined by its high prevalence in the population.…”