Marquage de la Pregnenolone au Carbjne 14 et au Deuterium en Position 21

Abstract

NOTE "IQUAGE DE LA PFEGNENOLONE AU CAPBINE 14 FT AU DEUTERIUM EN POSITION 21 S W Y 5 Pregnenolone ( A -pregnen-3B-ol-20-one) is labelled with 14C and deuterium in position 21. The radioactive carbon is inserted by the means of diazomethane-14C. The deuteration is realized by the reduction of 21-diazo-pregnenolone under the action of iodhydric acid dissolved in D20.14 C et le chlorure de l'acide 6ti6nioue ac6tyl6 4. Signalons Outre la rn6thode utilis6e par PHILLAMY et SCHOLZ, au rroins tmis autres possibilit6s d'accGs 5 la pregn6nolone marqu6e ou non existent; elles ont not m m t 6t6 sucrg6r6es DRT OLmm (5).

Preparation of Carbon‐14‐Labeled Compounds via the [ 14 C]Cyanide Tree

“…Acyl halides and anhydrides form diazoketones, which upon treatment with HCl or HBr furnish a-haloketones, whereas HI reduces them to methyl ketones 148 . Aldehydes and cyclic ketones give fairly good yields of methyl ketones and ring-expanded homologs, respectively.…”