Marriage structure of Yakut populations: Ethnic composition and isonymy inbreeding

Autosomal recessive deafness 1A (DFNB1A) in Yakut population isolate in Eastern Siberia: extensive accumulation of the splice site mutation IVS1+1G>A in GJB2 gene as a result of founder effect

“…Consanguineous marriages were traditionally uncommon in the Yakut population, and the total inbreeding estimated by isonymy (F(it)) varies from 0 to 0.007576. 45 All these features taken together could influence the pattern of the DFNB1A prevalence associated with IVS1+1G4A mutation in the Yakut population.…”