The exploration of the planet Mars represents a significant milestone in humanity's exploration of the Universe. In the quest to better explore and understand Mars, issues of forward and backward contamination are particularly pertinent. This paper provides an interdisciplinary analysis of forward and backward contamination. Its substantive material reflects the scientific and technical concerns through the looking glass of legal and policy issues, and vice versa. The paper critically surveys contamination issues of current, nascent and proposed Mars missions from a scientific viewpoint. It then makes a comparative review of legal and policy mechanisms designed to protect against such contamination. It draws cross-linkages between the sciences and the law in this area. The paper then delineates a suggested interdisciplinary framework to protect against forward and backward contamination. This framework is based on cooperation between the various nations undertaking Mars missions, as well as between the various fields of expertise. It highlights the importance of an interdisciplinary overview in the implementation of measures protecting against forward and backward contamination. Strategies on the implementation of these measures are also outlined.