MART-10, the vitamin D analog, is a potent drug to inhibit anaplastic thyroid cancer cell metastatic potential

Chiang, Kun‐Chun; Kuo, Sheng‐Fong; Chen, Chih‐Hung; Ng, Sohching; Lin, Shu-Fu; Yeh, Chun‐Nan; Chen, Liwei; Takano, Masashi; Chen, Thomas; Juang, Horng‐Heng; Kittaka, Atsushi; Lin, Jen‐Der; Pang, Jong‐Hwei S.

doi:10.1016/j.canlet.2015.07.024

Cited by 35 publications

(25 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vitro, 1,25(OH) 2 D and a new less-calcemic vitamin D analog, MART-10, could effectively repress ATC cell migration and invasion through reversing cadherin switch, blocking EMT processes, and downregulating the formation of F-actin. As MART-10 shows more potent attenuation of ATC cell metastatic potential than 1,25(OH) 2 D, and considering that MART-10 has been confirmed to be active in vivo without inducing any obvious side effects, further in vivo study of the applicability of MART-10 for ATC treatment is warranted [ 56 ]. In another study, 1,25(OH) 2 D was shown to inhibit the proliferation of thyroid cancer stem cells derived from ATC via G2/M phase cell cycle arrest [ 57 ].…”

Section: Vitamin D and Thyroid Cancersmentioning

confidence: 99%

The Role of Vitamin D in Thyroid Diseases

Kim

2017

IJMS

197

144

View full text Add to dashboard Cite

The main role of vitamin D is regulating bone metabolism and calcium and phosphorus homeostasis. Over the past few decades, the importance of vitamin D in non-skeletal actions has been studied, including the role of vitamin D in autoimmune diseases, metabolic syndromes, cardiovascular disease, cancers, and all-cause mortality. Recent evidence has demonstrated an association between low vitamin D status and autoimmune thyroid diseases such as Hashimoto’s thyroiditis and Graves’ disease, and impaired vitamin D signaling has been reported in thyroid cancers. This review will focus on recent data on the possible role of vitamin D in thyroid diseases, including autoimmune thyroid diseases and thyroid cancers.

show abstract

Section: Vitamin D and Thyroid Cancersmentioning

confidence: 99%

The Role of Vitamin D in Thyroid Diseases

Kim

2017

IJMS

197

144

View full text Add to dashboard Cite

show abstract

“…In the majority of tumor cells, N-cadherin displaces E-cadherin during the EMT (25). N-cadherin has several functions that are distinct from the functions of E-cadherin, including fibroblast growth factor receptor 1 activity stimulation, which leads to cell invasion and heterotypic cell-cell adhesions (26).…”

Section: Discussionmentioning

confidence: 99%

15-Deoxy-Δ12,14-prostaglandin J2 inhibits migration of human thyroid carcinoma cells by disrupting focal adhesion complex and adherens junction

Jhao

Cheng

et al. 2017

Oncology Letters

View full text Add to dashboard Cite

Metastasis is frequently observed in human follicular thyroid carcinoma. The present study investigated the peroxisome proliferator-activated receptor γ agonist, 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), and its effect on the migration of CGTH W-2 human thyroid carcinoma cells. 15d-PGJ2 decreased the survival rate of CGTH W-2 cells in a dose-dependent manner. The Transwell migration assay demonstrated that 15d-PGJ2 reduced the migration rate of CGTH W-2 cells by 35% following treatment with 30 µM 15d-PGJ2 compared with control cells. The cell adhesion assay indicated that, following 15d-PGJ2 treatment for 24 h, cell adhesion decreased by 26% compared with the control group. The expression levels of focal adhesion proteins, including integrin β1, phospho-focal adhesion kinase and p-paxillin, were downregulated following treatment with 15d-PGJ2. Immunostaining revealed that the puncta of vinculin were reduced and the actin stress fiber was disassembled following 15d-PGJ2 treatment. By contrast, p120-catenin (p120-ctn) and β-catenin levels staining accumulated in the region of the lamellipodium following 15d-PGJ2 treatment. Membrane fractionation revealed that p120-ctn and N-cadherin were decreased in the cell membrane, but increased in the cytoplasm of 15d-PGJ2-treated cells. Therefore, 15d-PGJ2 inhibited human thyroid carcinoma cell migration and this may be due to the impairment of focal adhesion complexes and the accumulation of p120-ctn in the cytoplasm in the region of the lamellipodium.

show abstract

“…It has been demonstrated that MART-10 is more potent than 1α,25(OH)2D3 to repress cancer growth and metastasis in undifferentiated thyroid cancer cells. These results require further investigations and in vivo study to use MART-10 as potent drug to inhibit anaplastic thyroid cancer cell metastatic potential [ 62 ].…”

Section: Vitamin D and Thyroid Cancermentioning

confidence: 99%

Sunshine vitamin and thyroid

Nettore

Albano

Ungaro

et al. 2017

Rev Endocr Metab Disord

View full text Add to dashboard Cite

Vitamin D exerts its canonical roles on the musculoskeletal system and in the calcium/phosphorus homeostasis. In the last years, increasing evidences suggested several extra-skeletal actions of this hormone, indicating that vitamin D may produce effects in almost all the body tissues. These are mediated by the presence of vitamin D receptor (VDR) and thanks to the presence of the 1-α-hydroxylase, the protein that converts the 25-hydroxyvitamin (calcidiol) to the active form 1,25-dihydroxyvitamin (calcitriol). Several studies evaluated the possible role of vitamin D in the pathogenesis of thyroid diseases, and this review will focus on the available data of the literature evaluating the association between vitamin D and thyroid function, vitamin D and autoimmune thyroid diseases, including Hashimoto’s thyroiditis, Graves’ disease and post-partum thyroiditis, and vitamin D and thyroid cancer.

show abstract

MART-10, the vitamin D analog, is a potent drug to inhibit anaplastic thyroid cancer cell metastatic potential

Cited by 35 publications

References 51 publications

The Role of Vitamin D in Thyroid Diseases

The Role of Vitamin D in Thyroid Diseases

15-Deoxy-Δ12,14-prostaglandin J2 inhibits migration of human thyroid carcinoma cells by disrupting focal adhesion complex and adherens junction

Sunshine vitamin and thyroid

Contact Info

Product

Resources

About