Más allá del diagnóstico fotodinámico: buscando la excelencia en el diagnóstico del cáncer vesical no músculo-invasivo

Encina, J. Oliva; Valdenebro, A. Marco; Gabarró, Jaume; Sanz, Carlos Rioja

doi:10.1016/j.acuro.2010.03.035

Cited by 9 publications

(2 citation statements)

References 35 publications

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“…This might partly be because of the insufficient resection depth of lateral-wall tumor during CM-TURBT, to reduce the risk of bladder perforation. [19] In HoL-EBRBT, the holmium laser can instantly coagulate the blood and lymph vessels, reducing the chance of intraoperative dissemination of the cancer cells. [20] Besides, holmium laser can resect neoplasm as well as adjacent tissues en bloc without touching the tumor, reducing the possibility of recurrence in situ .…”

Section: Discussionmentioning

confidence: 99%

Holmium laser transurethral resection of bladder tumor: Our experience

Dsouza

Verma

2016

Urol Ann

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Purpose:To compare the safety and efficiency of conventional monopolar and holmium laser en bloc transurethral resection of bladder tumor (CM-TURBT and HoL-EBRBT) while managing primary nonmuscle-invasive bladder cancer.Materials and Methods:From January 2012 to October 2015, fifty patients with primary nonmuscle-invasive bladder cancer underwent endoscopic surgery. Among them, 27 patients underwent CM-TURBT and 23 patients underwent HoL-EBRBT. Clinical data, included preoperative, operative, and postoperative management and follow-up, were recorded.Results:Patient demographics and tumor characteristics in both groups were compared before surgery. There was no significant difference in operative duration among the groups. Compared with the CM-TURBT group, HoL-EBRBT group had less intraoperative and postoperative complications, including obturator nerve reflex (P < 0.01), bladder perforation (P < 0.01), as well as bleeding and postoperative bladder irritation (P < 0.01). There were no significant differences among the two groups in the transfusion rate and occurrence of urethral strictures. Patients in the HoL-EBRBT group had less catheterization and hospitalization time than those in the CM-TURBT group (P < 0.01), and there were no significant differences in each risk subgroup as well as the overall recurrence rate among the CM-TURBT and HoL-EBRBT groups.Conclusions:HoL-EBRBT might prove to be preferable alternatives to CM-TURBT management of nonmuscle-invasive bladder cancer. HoL-EBRBT however did not demonstrate an obvious advantage over CM-TURBT in tumor recurrence rate.

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Section: Discussionmentioning

confidence: 99%

Holmium laser transurethral resection of bladder tumor: Our experience

Dsouza

Verma

2016

Urol Ann

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“…In contrast, an inadequate resection depth of the basal parts of tumors during TURBT to avoid bladder perforation may have resulted in a higher recurrence rate [ 24 ]. In addition, it is easier to form encrustation when using electrocautery to stop bleeding during TURBT, which may result in tumor cells remained in situ [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of transurethral laser therapy for bladder cancer: a systematic review and meta-analysis

et al. 2014

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BackgroundTransurethral laser therapy techniques are increasingly being used in the management of bladder tumors. It has reportedly been associated with good outcomes in small case series. The objective of the present study was to review the published literature and compare transurethral laser therapy for non–muscle-invasive bladder cancer (NMIBC) and conventional transurethral resection of bladder tumor (TURBT).MethodsWe performed a systematic review and meta-analysis based on randomized controlled trials (RCTs) and controlled clinical trials (CCTs) to assess the two techniques. The eligible RCTs and CCTs were identified in the following electronic databases: PubMed, the Cochrane Central Register of Controlled Trials and Embase.ResultsSeven studies were included in this systematic review. The baseline characteristics of these studies are comparable. We found no statistical difference between the two techniques regarding operative time. The intra- and postoperative complications showed that the laser procedure was better than TURBT for NMIBC, including obturator nerve reflex, bladder perforation, bladder irrigation rate, duration of catheterization and length of hospital stay. In addition, the 2-year recurrence-free survival improved in the laser group than in the TURBT group.ConclusionsOur systematic review and meta-analysis suggests that laser techniques are feasible, safe, effective procedures that provide an alternative treatment for patients with NMIBC. Given that some limitations cannot be overcome, well-designed RCTs are needed to confirm our findings.

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A clinical study of a CD44v6-targeted fluorescent agent for the detection of non-muscle invasive bladder cancer

Shang

Peng

et al. 2022

Eur J Nucl Med Mol Imaging

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Bladder cancer is the fth most common malignancy in humans. Cystoscopy under white light imaging is the gold standard for bladder cancer diagnosis, but some tumors are di cult to visualize and can be overlooked, resulting in high recurrence rates. Method:We developed a phage display-derived peptide-based near-infrared imaging probe, PLSWT7-DMI, which binds speci cally to bladder cancer cells and is nontoxic to animals. Here, we report a clinical research of this probe for near-infrared uorescence endoscopic detection of bladder cancer. ResultsThe purity, e cacy, safety, and nontoxicity of PLSWT7-DMI were con rmed prior to its clinical application. Twenty-two patients diagnosed with suspected non-muscle invasive bladder cancer were enrolled in the present study. Following intravesical administration of the probe, the entire mucosa was imaged under white and near-infrared imaging using an in-house developed endoscope that could switch between these two modes. The illuminated lesions under near-infrared light were biopsied and sent for histopathological examination. We observed a 5.1-fold increase in the uorescence intensity in the tumor samples compared to normal tissue, and the probe demonstrated a sensitivity and speci city of 91.2% and 90%, respectively. Common diagnostic challenges, such as small satellite tumors, carcinoma in situ, and benign suspicious mucosa, were visualized and could be distinguished from cancer. Further, no adverse effects were observed in humans. ConclusionThese rst-in-human results indicate that PLSWT7-DMI-based near-infrared uorescence endoscopy is a safe and effective approach for the improved detection of bladder cancer, and may enable thorough resection to prevent recurrence.

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Más allá del diagnóstico fotodinámico: buscando la excelencia en el diagnóstico del cáncer vesical no músculo-invasivo

Cited by 9 publications

References 35 publications

Holmium laser transurethral resection of bladder tumor: Our experience

Holmium laser transurethral resection of bladder tumor: Our experience

Safety and efficacy of transurethral laser therapy for bladder cancer: a systematic review and meta-analysis

A clinical study of a CD44v6-targeted fluorescent agent for the detection of non-muscle invasive bladder cancer

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