Masquelet technique for the treatment of bone defects: Tips-tricks and future directions

Giannoudis, Peter V.; Faour, Omar; Goff, Thomas; Kanakaris, Nikolaos K.; Dimitriou, Rozalia

doi:10.1016/j.injury.2011.03.036

Cited by 350 publications

(246 citation statements)

References 32 publications

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“…The drawbacks of the first method are infection around the fixator pins, inflammatory infiltration of the neighbouring joint space, a relatively long time of rehabilitation, high cost and a considerable non-union rate. The second method stipulates extensive operative experience, specialised medical staff (microsurgical techniques) and runs the risk of necrosis or resorption of the graft, increased morbidity of the donor site and extended operative times [2,3].…”

Section: Discussionmentioning

confidence: 99%

“…The Masquelet technique is an alternative method for bone defect management, comprised of two stages, each with its own "tips and tricks", in order to reduce relevant complications and increase effectiveness [3]. The first stage, known as "formation of the induction membrane" includes bone debridement and filling of the gap with a cement spacer (PMMA).…”

Section: Discussionmentioning

confidence: 99%

“…The second is a biological one; it promotes the formation of the cement-surrounding membrane. Histological studies on rabbits demonstrated extensive Implementation of the Masquelet Technique in Complicated Septic Non-union of the Ulna-A case Report 296 neovascularisation in the bone defect, whereas immunohistochemical studies denoted production of growth hormones (VEGF,TGF-b1) in a time period of two weeks, as well as the osteoinductive growth hormone BMP-2 (bone morphogenetic protein 2), with peak output at 9 weeks [3,[5][6][7][8][9][10]. These molecules are vital to bone formation, metabolism and remodelling [6].…”

Section: Discussionmentioning

confidence: 99%

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Implementation of the Masquelet Technique in Complicated Septic Non-union of the Ulna—A Case Report

Kyriakopoulos¹,

Trintafyllopoulos²,

Kostakos³

et al. 2016

JPP

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Long bone septic non-union by MRSA (methicillin-resistant Staphylococcus aureus) is always a challenge for the orthopaedic society. Traditional treatment options include distraction osteogenesis methods and vascularised bone grafting. These techniques require a high level of expertise and are frequently involved with a variety of side effects or complications. We present a rare case of ulnar fracture complicated by MRSA infection that led to septic non-union. We treated the septic non union with the technique of induced membrane formation (Masquelet technique). A 33 year old male presented to the outpatient clinic, 2 months after internal fixation of a Gustillo I fracture of the left forearm. There was pus discharge from the operative wound and specimen culture was positive for MRSA. Initially the patient received conservative treatment with antibiotics for a period of one month. However, the patient returned with the same clinical presentation. The patient was then treated with hardware removal of the ulna and debridement of the septic non-union. The formed 5 cm bone defect was filled with cement spacer and the ulnar bone was fixed with external fixation. Eight weeks later, the spacer was removed and the bone gap was filled with autologous cancellous bone graft from iliac crest. Five months after grafting, the patient was reviewed. No clinical or functional problems were noted and osseous consolidation of the ulnar bone was confirmed in plain x-rays. The Masquelet technique is a promising alternative treatment for the management of infected long bone non-unions of the upper extremity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Implementation of the Masquelet Technique in Complicated Septic Non-union of the Ulna—A Case Report

Kyriakopoulos¹,

Trintafyllopoulos²,

Kostakos³

et al. 2016

JPP

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“…La técnica de Masquelet o de inducción membrana consta de dos etapas, durante la primera se coloca en el DOPT un espaciador hecho a mano con PMMA impregnado con antibiótico (18)(19)(20). El espaciador induce la formación de la membrana de Masquelet, que es un tejido vascularizado rico en factores de crecimiento como el factor de crecimiento del endotelio vascular (VEGF) y factor de crecimiento transformante beta (TGF-ß1) (21,22).…”

Section: Introductionunclassified

“…La segunda etapa se realiza entre cuatro a ocho semanas después: se retira el espaciador preservando cuidadosamente la membrana inducida y se sustituye por injerto óseo esponjoso autólogo, La función de la membrana inducida es rodear al injerto óseo y nutrirlo, evitando su reabsorción. La estabilidad definitiva del hueso puede realizarse con fijación externa o interna (19,20).…”

Section: Introductionunclassified

Reconstrucción de defectos óseos segmentarios postraumáticos mediante técnica de inducción de membrana

et al. 2015

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The Lower Limb

Richards¹,

Dafydd

2014

Key Notes on Plastic Surgery

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Masquelet technique for the treatment of bone defects: Tips-tricks and future directions

Cited by 350 publications

References 32 publications

Implementation of the Masquelet Technique in Complicated Septic Non-union of the Ulna—A Case Report

Implementation of the Masquelet Technique in Complicated Septic Non-union of the Ulna—A Case Report

Reconstrucción de defectos óseos segmentarios postraumáticos mediante técnica de inducción de membrana

The Lower Limb

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