Mass spectrometric diagnosis of an atmospheric pressure helium microplasma jet

McKay, Kirsty; Oh, Jun Seok; Walsh, James L.; Bradley, James W.

doi:10.1088/0022-3727/46/46/464018

Cited by 60 publications

(67 citation statements)

References 40 publications

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“…Congruent results, concerning the ambient impurities present in the discharge effluent, were also reported by other research groups for various types of atmospheric pressure plasma jets [18][19][20][21]64]. This rich ion chemistry is only due to air impurities diffusion in the rare gas channel and it may be modified for desired applications if small amounts, less than 1% of additional gases (e.g., O 2 , N 2 , CO 2 or H 2 O), are mixed with the main working gas.…”

Section: Influence Of a Third Electrodesupporting

confidence: 68%

“…To extract positive or negative charged species from plasma volume, the aligned cones were properly biased, tuned for a maximum signal and carefully adjusted so as to not induce additional ionizations processes. The first cone is not grounded (as factory default) and the diameter of the extraction orifice was 100 µm, similar to most previous mass spectrometry studies of APPJ [21][22][23][24][25][26] or basic inductively coupled plasma-mass spectrometry set-ups. It worth to note that in some other studies the extraction orifice was smaller [27] or not mentioned [20,28].…”

Section: Experimental Set-up and Methodsmentioning

confidence: 84%

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Time Behaviour of Helium Atmospheric Pressure Plasma Jet Electrical and Optical Parameters

et al. 2017

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Low temperature plasma jets gained increased interest in the last years as a potential device in many life science applications, including here human or veterinary medicine. Standardisation of plasma sources and biological protocols are necessary for quality assurance reasons, due to the fact that this type of atmospheric pressure plasma source is available in multiple configurations and their operational parameters span also on a broad range of items, such as all characteristics of high voltage pulses used for gas breakdown, geometrical characteristics, gas feed composition and conductive or biological target characteristics. In this paper we present results related to electrical, optical and molecular beam mass spectrometry diagnosis of a helium plasma jet, emphasising the influence of various operational parameters of the high voltage pulses on plasma jet properties. Discussion on physical parameters that influence the biological response is included, together with important results on plasma sources statistical behaviour until reaching a quasi-stationary working regime. The warm-up period of the plasma jet, specific to many other plasma sources, must be precisely known and specified whenever the plasma jets are used as a tool for life science applications.

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Section: Influence Of a Third Electrodesupporting

confidence: 68%

Section: Experimental Set-up and Methodsmentioning

confidence: 84%

Time Behaviour of Helium Atmospheric Pressure Plasma Jet Electrical and Optical Parameters

et al. 2017

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“…When operated into the ambient air, the reactive plasma effluent activates the neutral oxygen and nitrogen species generating a rich mixture of RONS [8][9][10][11][12]; these are subsequently delivered to the biological target by the plasma and gas flow. Atmospheric-pressure, molecular beam mass spectrometric studies have revealed secondary reactive species including tens of positively charged species and hundreds of negatively charged species and neutrals are generated by the interaction between the APPJ and / or APPJ effluent (primary species e.g.…”

Section: Introductionmentioning

confidence: 99%

In-situ UV Absorption Spectroscopy for Monitoring Transport of Plasma Reactive Species through Agarose as Surrogate for Tissue

Szili

Gaur

et al. 2015

J. Photopol. Sci. Technol.

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We demonstrated the efficacy of using a simple experimental approach, involving UV absorption spectroscopy, to monitor the transport of reactive oxygen and nitrogen species (RONS) through an agarose film (as surrogate for real tissue) into deionized (DI) water. The experiment involved placing a 4 mm thick agarose film over a quartz cuvette filled with DI water. The agarose film was exposed to a non-thermal, He atmospheric-pressure plasma jet (APPJ) and the UV absorption of the DI water was recorded in real-time. Our results indicate an accumulation of RONS within the agarose film during APPJ exposure and a subsequent time-lapsed release of RONS into the DI water. Curve fitting of the UV spectra suggested the APPJ transported and / or generated at least four RONS (NaNO 2 , HNO 3 , H 2 O 2 and O 2 ) through the 4 mm thick agarose film. Our approach of analyzing the delivery depth of RONS through synthetic tissue targets might find use in the future development of APPJ medical therapies and for improving our understanding of APPJ interactions with soft tissue.

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“…We show and discuss the species with mass-to-charge ratios (m/z) up to 100 amu. We used the HPR60-EQP300 system (Hiden Analytical Ltd.) [22][23][24][25]. It consists of a differential pumping system (HPR60) and the quadrupole based mass spectrometer (EQP300).…”

Section: Ambient Mass Spectrometrymentioning

confidence: 99%

Mass Spectrometry Analysis of the Real-Time Transport of Plasma-Generated Ionic Species Through an Agarose Tissue Model Target

Szili

Hong

et al. 2017

J. Photopol. Sci. Technol.

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With ambient mass spectrometry, we followed the transport of neutral gas species and ionic species through a 3.2 mm thick agarose tissue model target during He non-thermal atmospheric pressure plasma (NT-APP) jet treatment. We found that the neutral gas species are unable to efficiently penetrate the agarose target. But both positively and negatively charged ionic species readily penetrate through the agarose target, following an initial timelag period of several minutes. Interestingly, we also found that the ionic species are easily hydrated. The trends in the He NT-APP jet transport of ionic species observed in this study correlate well with the He NT-APP jet transport of reactive oxygen and nitrogen species (RONS) through agarose tissue model targets that was investigated in previous studies. Therefore, mass spectrometry might prove to be a useful tool in the future for analyzing the dosages of NT-APP-generated RONS in real biological tissues.

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Mass spectrometric diagnosis of an atmospheric pressure helium microplasma jet

Cited by 60 publications

References 40 publications

Time Behaviour of Helium Atmospheric Pressure Plasma Jet Electrical and Optical Parameters

Time Behaviour of Helium Atmospheric Pressure Plasma Jet Electrical and Optical Parameters

In-situ UV Absorption Spectroscopy for Monitoring Transport of Plasma Reactive Species through Agarose as Surrogate for Tissue

Mass Spectrometry Analysis of the Real-Time Transport of Plasma-Generated Ionic Species Through an Agarose Tissue Model Target

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