Massachusetts general hospital Covid-19 registry reveals two distinct populations of hospitalized patients by race and ethnicity

Abstract

Objective To evaluate differences by race/ethnicity in clinical characteristics and outcomes among hospitalized patients with Covid-19 at Massachusetts General Hospital (MGH). Methods The MGH Covid-19 Registry includes confirmed SARS-CoV-2-infected patients hospitalized at MGH and is based on manual chart reviews and data extraction from electronic health records (EHRs). We evaluated differences between White/Non-Hispanic and Hispanic patients in demographics, complications and 14-day outcomes among the N = 866 patients hospitalized with Covid-19 from March 11, 2020—May 4, 2020. Results Overall, 43% of patients hospitalized with Covid-19 were women, median age was 60.4 [IQR = (48.2, 75)], 11.3% were Black/non-Hispanic and 35.2% were Hispanic. Hispanic patients, representing 35.2% of patients, were younger than White/non-Hispanic patients [median age 51y; IQR = (40.6, 61.6) versus 72y; (58.0, 81.7) (p<0.001)]. Hispanic patients were symptomatic longer before presenting to care (median 5 vs 3d, p = 0.039) but were more likely to be sent home with self-quarantine than be admitted to hospital (29% vs 16%, p<0.001). Hispanic patients had fewer comorbidities yet comparable rates of ICU or death (34% vs 36%). Nonetheless, a greater proportion of Hispanic patients recovered by 14 days after presentation (62% vs 45%, p<0.001; OR = 1.99, p = 0.011 in multivariable adjusted model) and fewer died (2% versus 18%, p<0.001). Conclusions Hospitalized Hispanic patients were younger and had fewer comorbidities compared to White/non-Hispanic patients; despite comparable rates of ICU care or death, a greater proportion recovered. These results have implications for public health policy and the design and conduct of clinical trials.

Latin American Origin Is Not Associated with Worse Outcomes among Hospitalized Patients with COVID-19 in a Public Healthcare System

“…Conversely, in other cohort studies, Ogedegbe et al [ 14 ], Kabarriti et al [ 15 ], and Rodriguez et al [ 16 ] reported that the rates of adverse outcomes of COVID-19 did not differ by race/origin after adjustment for sociodemographic and clinical characteristics. Consistent with this evidence, Bassett et al [ 18 ] showed that Hispanic/Latin American patients had fewer comorbidities, but comparable rates of ICU admission and death [ 18 ]. Globally, we can deduce that the higher crude mortality seen in Latin Americans is not generally confirmed after adjusting for COVID-19-cause-of-death.…”

Sex differences in inflammatory markers in patients hospitalized with COVID-19 infection: Insights from the MGH COVID-19 patient registry

“…This retrospective observational study included adults with confirmed COVID-19 infection who met criteria for inpatient admission at the Massachusetts General Hospital between March 8 to April 27, 2020 [12]. We excluded patients with active cancer except non-melanoma ).…”

COVID-19 severity in hospitalized patients with asthma: A matched cohort study

“…We performed a matched cohort study using data from the MGH COVID-19 Data Registry for confirmed SARS-CoV-2 infected patients hospitalized at MGH. 4 The registry included 866 COVID-19 inpatients (hospitalized March 8, 2020, to April 27, 2020) and was created using both manual chart review and coded data extraction from the electronic health record in the Mass General Brigham Enterprise Data Warehouse. Trained chart reviewers extracted demographics, comorbid conditions, intensive care unit (ICU) admission, clinical complications, and death.…”