1995
DOI: 10.1006/bbrc.1995.1505
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Mast Cell Chemotactic Activity of RANTES

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Cited by 63 publications
(43 citation statements)
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“…3 We observed that, compared to vehicle treatment, CP55,940 treatment of sickle mice for 3 weeks significantly decreased the cytokines released from skin biopsies (IL-1α, IL-6, TNF-α, MCP-1; P<0.01, Figure 2H). Consistent with decreased mast cell activation, treatment with CP55,940 lowered the levels of granulocte macrophage colony-stimulating factor (GM-CSF) and regulated on activation, normal T-cell expressed and secreted (RANTES), two chemokines involved in mast cell recruitment and function, 24,25 by at least 35% (P<0.01). GM-CSF plays a critical role in regulating leukocyte counts, which are often elevated in SCA.…”
Section: Cannabinoids Attenuate Mast Cell Activation In Sickle Cell Amentioning
confidence: 93%
“…3 We observed that, compared to vehicle treatment, CP55,940 treatment of sickle mice for 3 weeks significantly decreased the cytokines released from skin biopsies (IL-1α, IL-6, TNF-α, MCP-1; P<0.01, Figure 2H). Consistent with decreased mast cell activation, treatment with CP55,940 lowered the levels of granulocte macrophage colony-stimulating factor (GM-CSF) and regulated on activation, normal T-cell expressed and secreted (RANTES), two chemokines involved in mast cell recruitment and function, 24,25 by at least 35% (P<0.01). GM-CSF plays a critical role in regulating leukocyte counts, which are often elevated in SCA.…”
Section: Cannabinoids Attenuate Mast Cell Activation In Sickle Cell Amentioning
confidence: 93%
“…The factors that stimulate mast cell migration remain largely undefined, although recent reports have implicated stem cell factor, C3a and C5a, RANTES, interleukin-8 (IL-8), and serum amyloid A protein to be involved [2][3][4][5][6][7][8]. Other potential candidates for acting as mast cell chemotaxins are members of the transforming growth factor-␤ (TGF-␤) family, which include TGF-␤1, -␤2, -␤3, activins, and bone morphogenetic proteins [reviewed in ref .…”
Section: Introductionmentioning
confidence: 99%
“…The increase in the number of mast cells at the local tissue may result from their proliferation and directional movement. There are various kinds of cytokines (6 -11) and chemoattractants (12)(13)(14)(15)(16)(17)(18)(19) which not only induce chemotactic movement of mast cells but also promote their other functional abilities. Much is known that cross-linking of IgE bound to Fc⑀RI by specific Ag mediates rapid release of biologically active chemical mediators and production of proinflammatory cytokines.…”
mentioning
confidence: 99%