Mast cell chymase expression and mast cell phenotypes in human rejected kidneys

Abstract

These results show that increased expression of chymase in MCs is related to the severity of interstitial fibrosis in human rejected kidneys.

The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease

“…In the ischemic kidneys of two-kidney, one-clip rats and in kidneys of subtotal nephrectomized rats, increases in chymase activity and expression are also observed (Sadjadi et al, 2005a). Clinical studies reported increased chymase expression in rejected kidneys (Yamada et al, 2001) and kidneys of patients with renovascular hypertension (Morikawa et al, 2005) and diabetes (Huang et al, 2003;Koka et al, 2006). Collectively, these data support the potential contribution of chymase-dependent intrarenal Ang II formation to the progression of renal injury.…”

Mast Cell Phenotypes in the Allograft After Lung Transplantation.

“…This is in consonance with the phenotypic switch of MC T to MC TC and its association with allograft fibrosis that has been reported post-renal transplantation. 21,22 Nevertheless, whether MC TC phenotype is independently linked to development of CLAD, or more significantly, plays a pathologic role in CLAD remains to be investigated.…”

Pathogenic role of mast cells in the development of diabetic nephropathy: a study of patients at different stages of the disease

“…Previous studies suggested that MCs contributed to renal diseases mainly through promotion of tubular interstitial injury [13,[15][16][17][32][33][34]. Most investigations focused on the roles of MCs on renal fibrosis.…”

“…The MC T MCs are believed to be T cell-dependent and the MC TC MCs are believed to be T cell-independent [38]. In human renal tissue, different results have been reported on MC subtype [11,15,17,[32][33][34]. MC subtype is believed to be disease-dependent [16].…”