Mast-cell-dependent histamine release after praziquantel treatment of Schistosoma japonicum infection: implications for chemotherapy-related adverse effects

Matsumoto, Jun; Matsuda, Hajime

doi:10.1007/s00436-002-0677-5

Cited by 5 publications

(5 citation statements)

References 15 publications

(19 reference statements)

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“…In this study, praziquantel given in single doses of 40 mg/kg and 60 mg/kg eliminated all heavy intensity infections and showed very high cure rates and egg reduction rates post-treatment. These findings confirm the excellent profile of praziquantel in terms of cure rates and reduction in intensity of infection [23][24][25]. This study also supports the use of a single dose of 40 mg/kg of praziquantel in mass chemotherapy campaigns, while the higher dose of 60 mg/kg is reserved for individuals with heavy intensity infection or cerebral schistosomiasis [6,26].…”

Section: Discussionsupporting

confidence: 84%

Efficacy and safety of 40 mg/kg and 60 mg/kg single doses of praziquantel in the treatment of schistosomiasis

Belizario

Amarillo

Martínez

et al. 2015

J Pediatr Infect Dis

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The aim of this study was to compare the efficacy, safety and reinfection rates at 6 and 12 months after treatment of schistosomiasis with praziquantel 60 mg/kg single dose, as compared to the standard 40 mg/kg single dose regimen. A school-based randomized, double blind, experimental drug trial was implemented in Bunawan and Trento, in the province of Agusan del Sur, Philippines. The Kato Katz technique was used for quantitative assessment of Schistosoma japonicum infection. Follow-up visits were done 21, 180 and 360 days post-treatment. Efficacy, safety and reinfection rates of the two treatment regimens were compared using Student's t-test, Chi-square/Fisher's exact test and analysis of variance. There were 102 and 101 patients assigned to the 40 mg/kg and 60 mg/kg treatment groups, respectively. On day 21 post-treatment, 95% and 98.0% of the patients were cured, with egg reduction rates were of 99.9% and 99.99%, respectively. Remaining infections were of light intensity. On days 180 and 360, infection rates increased, with re-emergence of moderate and heavy intensity infections. On treatment day, the cumulative prevalence of adverse events in the 60 mg/kg treatment group was significantly higher than in the 40 mg/kg treatment group (P = 0.002). In conclusion, praziquantel 40 mg/kg and 60 mg/kg single dose therapy had comparable efficacy. A significantly higher prevalence of adverse events, mostly mild and transient, was observed in the 60 mg/kg regimen. The 40 mg/kg regimen is recommended for the treatment of schistosomiasis. High reinfection rates suggest the need to re-examine behavioral and environmental factors in the community.

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Section: Discussionsupporting

confidence: 84%

Efficacy and safety of 40 mg/kg and 60 mg/kg single doses of praziquantel in the treatment of schistosomiasis

Belizario

Amarillo

Martínez

et al. 2015

J Pediatr Infect Dis

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“…Given the peri-intestinal location of adult worms and eggs, activation of mucosal mast cells may contribute to transient antigen-dependent IL-5 production after treatment. This is supported by the observation that, in mice infected with S. japonicum, there is rapid activation of mast cells following PZQ treatment (33).…”

Section: Vol 72 2004 Schistosomiasis Cure In Ugandan Men: Immune Rementioning

confidence: 65%

Chemotherapy for Schistosomiasis in Ugandan Fishermen: Treatment Can Cause a Rapid Increase in Interleukin-5 Levels in Plasma but Decreased Levels of Eosinophilia and Worm-Specific Immunoglobulin E

et al. 2004

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Chemotherapy for blood-dwelling schistosomes kills the worms and exposes parasite antigen to the circulation. In many people from areas of endemicity, this treatment increases parasite-specific immunoglobulin E (IgE) and other Th2 responses in the months following therapy, responses that have been associated with subsequent resistance to reinfection. Here we investigate much earlier changes in immune reactions after praziquantel therapy in Schistosoma mansoni-infected fishermen working in an area of high transmission in Uganda. The subjects gave blood before treatment and at 1 and 21 days posttreatment. Blood cultures were incubated with schistosome soluble worm antigen (SWA) or soluble egg antigen (SEA). Interleukin-4 (IL-4), IL-5, IL-10, IL-13, gamma interferon, and transforming growth factor ␤ levels were measured in the cultures and in plasma. A marked transient increase in plasma IL-5 levels was observed in 75% of the subjects (n ‫؍‬ 48) by 1 day posttreatment. This response was dependent on pretreatment intensity of infection and was accompanied by a transient decrease in eosinophil numbers. One day posttreatment, blood cultures from the 16 subjects with the greatest increase in plasma IL-5 level (>100 pg/ml) displayed reduced IL-5, IL-13, and IL-10 responses to SWA, and in contrast to the rest of the cohort, these high-IL-5 subjects displayed reduced levels of SWA-specific IgE in plasma 21 days posttreatment. Twenty months after treatment, the intensity of reinfection was positively correlated with the increase in plasma IL-5 level seen 1 day posttreatment. These studies describe the heterogeneity in early immune reactions to treatment, identifying subgroups who have different patterns of reaction and who may have different capacities to mount the responses that have been associated with resistance to reinfection.Schistosomiasis is a condition caused by parasitic helminths of the genus Schistosoma, with S. mansoni, S. haematobium, and S. japonicum accounting for most of the world's estimated 200 million cases of human schistosomiasis. The disease is contracted from waterborne larvae that penetrate the skin and enter the bloodstream, where they develop, pair, and reach sexual maturity. Adult pairs of S. mansoni reside in the mesenteric veins of the intestine, where each female lays up to 300 eggs per day.In numerous treatment studies carried out in areas of endemicity (4,6,7,11,12,16,23,45,46), the intensity of reinfection after chemotherapy has been shown to be highest in children and adolescents and then to decrease during adult life. This suggests that acquired resistance to infection may develop gradually with age. It has, however, been difficult to draw firm conclusions from these age profiles, as in most communities of endemicity adults have less contact with infected water than do children. For this reason, Kabatereine et al. (28) examined the intensity of S. mansoni reinfection in a Ugandan fishing community following treatment with praziquantel (PZQ). Due to occupational contact with water in the...

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“…Where praziquantel has been used to treat schistosome infections in human beings, pretreatment infection intensity has been significantly associated with abdominal pain and diarrhoea shortly after the treatment (Boisier and others 1994, Stelma and others 1995, Jaoko and others 1996, N'Goran and others 2003, Raso and others 2004. The proposed cause of the side effects in the present study is a host anaphylactic reaction to parasite antigens released by prazi- quantel-induced disintegration of the tapeworm tegument (Harnett 1988, Matsumoto 2002, Matsumoto and Matsuda 2002.…”

mentioning

confidence: 74%

Postdosing colic and diarrhoea in horses with serological evidence of tapeworm infection

Barrett

Blair

Farlam³

et al. 2005

Veterinary Record

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Mast-cell-dependent histamine release after praziquantel treatment of Schistosoma japonicum infection: implications for chemotherapy-related adverse effects

Cited by 5 publications

References 15 publications

Efficacy and safety of 40 mg/kg and 60 mg/kg single doses of praziquantel in the treatment of schistosomiasis

Efficacy and safety of 40 mg/kg and 60 mg/kg single doses of praziquantel in the treatment of schistosomiasis

Chemotherapy for Schistosomiasis in Ugandan Fishermen: Treatment Can Cause a Rapid Increase in Interleukin-5 Levels in Plasma but Decreased Levels of Eosinophilia and Worm-Specific Immunoglobulin E

Postdosing colic and diarrhoea in horses with serological evidence of tapeworm infection

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