Mast cell ? Leukocyte interaction in increased vascular permeability of an inflammatory focus

Klimenko, N. A.

doi:10.1007/bf00787740

Cited by 3 publications

(6 citation statements)

References 10 publications

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“…The involvement of leukocytes in DP (correlating 'with their accumulation in the inflammatory focus [5,8]) and IP of the increase in VP is clear. Activation of leukocytes begins in the blood flow and results from their chemotactic stimulation.…”

Section: Resultsmentioning

confidence: 96%

“…Kluwer Acadernic/Plenum Publishers respectively) [5,8]. Peritoneal lavage was carried out with 5 ml isotonic NaC1 containing 5 U/ml heparin.…”

Section: Methodsmentioning

confidence: 99%

“…Trypan blue (1%) was administered intravenously in a dose of 5 ml/kg 5 min before decapitation, and VP was determined by colorimetry of peritoneal lavage [5]. Peak VP was studied during IP and DP of its increase (15 min and 5 h after injection of carrageenan, 0007-4888/99/0008-0800522.00 9…”

Section: Methodsmentioning

confidence: 99%

“…However, in the late exudative phase, VP was higher than during natural inflammation. These changes in VP correlated with leukocyte count in the inflammatory focus and peripheral blood [5,8].Here we studied the role of leukocytes in the regulation of VP during inflammation. VP in the inflammatory focus was determined in IP and DP of its increase during the recruitment of blood leukocytes in leukopenic animals and the use of lysosomal proteinase inhibitors, reactive oxygen species, cyclooxygenase, and lipoxygenase.…”

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confidence: 96%

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Role of leukocytes in increased vascular permeability in inflammation

Klimenko¹,

Павлова²

1999

Bull Exp Biol Med

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Carrageenan-induced acute aseptic peritonitis was used as a model of inflammation. In rats with irradiation-induced leukopenia, the immediate and delayed phases of increased vascular permeability in the inflammatory focus were mediated by leukocytes. In the immediate phase, lysosomal enzymes, reactive oxygen species, and cyclooxygenase and lipoxygenase metabolites of arachidonic acid are involved in the regulation of vascular permeability, while in the delayed phase, lysosomal enzymes and lipoxygenase derivatives play the major role. Dexamethasone sharply inhibits vascular permeability in both phases. Key Words: inflammation," vascular permeability; leukocytes; dexamethasoneOur previous experiments showed that irradiation-or vinblastine-induced leukopenia modulates vascular permeability (VP) in the inflammatory focus during the exudative phase by reducing the immediate phase (IP) and delayed phase (DP) of its increase. However, in the late exudative phase, VP was higher than during natural inflammation. These changes in VP correlated with leukocyte count in the inflammatory focus and peripheral blood [5,8].Here we studied the role of leukocytes in the regulation of VP during inflammation. VP in the inflammatory focus was determined in IP and DP of its increase during the recruitment of blood leukocytes in leukopenic animals and the use of lysosomal proteinase inhibitors, reactive oxygen species, cyclooxygenase, and lipoxygenase. The effects of dexamethasone on VP in the inflammatory focus were evaluated. MATERIALS AND METHODSExperiments were performed on 72 male Wistar rats weighing 180-200 g. Acute aseptic peritonitis induced by intraperitoneal injection of 5 mg )~-carrageenan (Sigma) in 1 ml isotonic NaCI was used as a model of inflammation [6]. Four days before peritonitis,

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Section: Resultsmentioning

confidence: 96%

“…Kluwer Acadernic/Plenum Publishers respectively) [5,8]. Peritoneal lavage was carried out with 5 ml isotonic NaC1 containing 5 U/ml heparin.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 96%

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Role of leukocytes in increased vascular permeability in inflammation

Klimenko¹,

Павлова²

1999

Bull Exp Biol Med

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“…The experiments were performed on 396 male Wistar rats weighing 180-200 g. Acute infectious peritonitis was induced by intraperitoneal injection of 2x109 cells (0.5 LDs0 ) of a one-day-old E. coli culture, isolated from a patient with peritonitis, in 1 ml isotonic NaC1 [5,7,8] …”

Section: Methodsmentioning

confidence: 99%

Role of mast cells in reparative processes in inflammation

Klimenko¹,

Татарко²

1995

Bull Exp Biol Med

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Using the model of acute infectious peritonitis in rats, it is shown that inflammation induced in the absence of mast cells is characterized by marked inhibition of reparative processes. The most significant accumulation of functionally active fibroblasts and the development of granulations and young connective tissue in the mesentery occur 5-10 days after flogogen injection in the natural development of inflammation and after 10-20 days in the absence of mast cells. The data suggest that under natural conditions mast cells directly or indirectly stimulate reparative processes. Key Words: inflammation; mast cells; repairAt present, mast ceils (MC) are considered to be the source of the main transmitters of initial vascular and exudative processes, in particular the immediate phase of the increase of vascular permeability [8,9] underlying exudation. Recently, a modulatory effect of MC on infdtration processes during inflammation has been shown and mechanisms of this effect dependent on the main products of MC, histamine, serotonin, and heparin, have been studied [6,7].The aim of the present study was to investigate the role of MC in reparative processes during inflammation. MATERIALS AND METHODSThe experiments were performed on 396 male Wistar rats weighing 180-200 g. Acute infectious peritonitis was induced by intraperitoneal injection of 2x109 cells (0.5 LDs0 ) of a one-day-old E. coli culture, isolated from a patient with peritonitis, in 1 ml isotonic NaC1 [5,7,8]

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The role of leukocytes in the reaction of mast cells from an inflammatory focus

Klimenko

1993

Bull Exp Biol Med

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Mast cell ? Leukocyte interaction in increased vascular permeability of an inflammatory focus

Cited by 3 publications

References 10 publications

Role of leukocytes in increased vascular permeability in inflammation

Role of leukocytes in increased vascular permeability in inflammation

Role of mast cells in reparative processes in inflammation

The role of leukocytes in the reaction of mast cells from an inflammatory focus

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