Mast Cell Tumors

Thamm, Douglas H.; Vail, David M.

doi:10.1016/b978-072160558-6.50022-8

Cited by 138 publications

(328 citation statements)

References 92 publications

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“…18 Grade is often predictive of biologic behavior, with grade I tumors behaving in a benign fashion and grade III tumors tending to follow a highly malignant course. 5,18,19,22,28,30 Many grade II tumors are treated successfully with surgical resection followed by local radiation therapy as needed, but there exists a subset of grade II tumors that spread to local lymph nodes as well as distant sites such as the spleen, liver, and internal lymph nodes, eventually leading to death of the affected patient. 18 Predicting the behavior of grade II MCTs has proven to be difficult, and this problem is confounded by the fact that despite specific guidelines for determination of grade (i.e., the Patnaik system), there is significant variation in grade assignment among pathologists.…”

Section: Discussionmentioning

confidence: 99%

“…Those patients with grade I tumors are likely to experience long-term survival, while those with grade III tumors have a reported median survival time of only 6 months. 5,18,19,22,28,30 Although most grade II MCTs are considered benign, a proportion of these will metastasize to local lymph nodes and distant sites. 18 While tumor grade is often used to determine prognosis, there is widespread disagreement on standardization of grading, as evidenced by a recent publication in which there was significant variation among 10 pathologists in the grading of the same set of 60 MCTs.…”

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Mitotic Index Is Predictive for Survival for Canine Cutaneous Mast Cell Tumors

et al. 2007

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Abstract. Mitotic index (MI) is an indirect measure of cell proliferation that has been demonstrated to be a strong predictor of outcome for several human and canine cancers. The purpose of this study was to evaluate the utility of MI as a predictor of biologic behavior and survival in dogs with cutaneous mast cell tumors (MCTs). Medical records from 148 dogs with histologically confirmed MCTs were reviewed. Information regarding tumor grade, local recurrence, metastatic disease, date of death/last follow-up, and outcome was obtained. The region of the tumor with the highest overall mitotic activity was chosen for evaluation, and the MI value was defined as the number of mitotic figures/10 high-power fields (4003, 2.7 mm 2 ). A Cox proportional hazards regression model was used to compare MI with survival data. A Mann-Whitney test was used to compare MI on the basis of the development of local recurrence and metastatic disease. The MI correlated directly with tumor grade (P , .0001). The median survival time for dogs with an MI #5 was significantly longer (70 months) than for those with an MI .5 (2 months), regardless of grade (P , .001). For grade II tumors with an MI #5, the median survival time (MST) was 70 months, compared with 5 months for those with an MI .5 (P , .001). For grade III tumors with an MI #5, the MST was not reached, compared with ,2 months for those with an MI .5 (P , .001). In conclusion, MI is a strong predictor of overall survival for dogs with cutaneous MCTs and should be included as a prognostic indicator when determining therapeutic options.

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Mitotic Index Is Predictive for Survival for Canine Cutaneous Mast Cell Tumors

et al. 2007

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“…Os dados do presente estudo corroboram a literatura , Webster et al 2007), pois os tumores nessas localizações estão relaQuadro 4. Distribuição das duas classificações histológicas, marcadores imuno-histoquímicos e análise da PCR Forrest (1997), que relatou que os mastocitomas nos membros tinham comportamento benigno, e com Oliveira (2008), que classificou a maioria dos mastocitomas no membro como de grau I. Os tumores disseminados apresentavam graus baixos e padrão perimembranoso, o que corrobora com os autores (Thamm et al 1999, Séguin et al 2001, Thamm & Vail 2001 que não os associam a piores prognósticos.…”

Section: Discussionunclassified

Comparação de duas classificações histopatológicas com o padrão de imuno-marcação para KIT, a avaliação da proliferação celular e com a presença de mutações no c-KIT de mastocitomas cutâneos caninos

Carvalho

Nardi

et al. 2017

Pesq. Vet. Bras.

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RESUMO: A graduação histopatológica é o método de eleição para prever o comportamento biológico do mastocitoma e, atualmente, são utilizados os métodos de Patnaik e de Kiupel para dividi-los em graus de malignidade. O objetivo do presente trabalho foi comparar as duas classificações histológicas com as variáveis clínicas, os marcadores imuno-histoquímicos e com a presença de mutações para verificar as características que estão mais relacionadas entre si e com os piores prognósticos. Foram avaliados 61 animais, levando em consideração o sexo, a raça, a idade, a localização tumoral, o grau tumoral pelas classificações de Patnaik e Kiupel, a infiltração de eosinófilos, a marcação do KIT e do Ki-67 e a presença de mutação. As variáveis foram correlacionadas utilizando os testes de qui-quadrado, teste de Fisher, teste de verossimilhança e o teste de risco relativo. Os animais idosos foram os mais acometidos, enquanto os animais sem raça definida e os das raças Boxer, Labrador e Pinscher foram aqueles com maior predisposição ao desenvolvimento tumoral. A localização e a idade estão associadas ao grau tumoral. Os tumores em cabeça, pescoço e região genital têm 10 vezes mais chance de serem classificados como de alto grau (RR=10,667; IC95% 1,909-59,615, p=0,004) e os idosos oito vezes mais chance (RR=8,00; IC95% 0,955-67,009; p=0,029). Os tumores de grau II e os de baixo grau foram os mais encontrados e as duas classificações histológicas demonstram correlação muito significativa entre si (p<0,001). A concentração do infiltrado eosinofílico não demonstrou correlação significativa com nenhuma das classificações histológicas. O padrão KIT foi dependente da localização tumoral (p=0,015), já que os tumores genitais, na cabeça e no pescoço possuíam 18 vezes mais chance de apresentarem padrão citoplasmático (RR=18,571; IC95% 1,954-176,490; p=0,003), e das classificações de Patnaik (p=0,001) e Kiupel (p<0,001), sendo que os tumores de alto grau têm 36 vezes mais chance de apresentarem padrão citoplasmático (RR=36,00, IC95% 4,35-297,948; p<0,001). A marcação do Ki-67 demonstrou dependência da localização (p=0,024). A presença de mutação no exon 11 do domínio justamembrana não demonstrou associação com nenhuma das variáveis clínicas, das classificações histológicas, da concentração de eosinófilos e do padrão KIT. A presença da mutação foi correlacionada significativamente apenas ao Ki-67 (p=0,010). Os resultados obtidos sugerem que a localização é a variável clínica mais relacionada ao prognóstico e que apenas a classificação de Kiupel associada à imuno-histoquímica são eficientes para avaliar o comportamento tumoral.

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“…This is 4 typically the case with cutaneous mast cell tumours (MCTs), actually the most common 5 skin neoplasms in dogs. The present review is focused on cutaneous MCTs, that should 6 not be confused with their visceral counterparts, since these display significantly canine MCTs treated according to Thamm and Vail (2007). These results had no 23 statistical significance, which may be due to the adjuvant therapy employed (which in 24 some cases included imatinib, a known c-kit inhibitor).…”

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C-kit as a prognostic and therapeutic marker in canine cutaneous mast cell tumours: From laboratory to clinic

Costa

2015

The Veterinary Journal

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Mast Cell Tumors

Cited by 138 publications

References 92 publications

Mitotic Index Is Predictive for Survival for Canine Cutaneous Mast Cell Tumors

Mitotic Index Is Predictive for Survival for Canine Cutaneous Mast Cell Tumors

Comparação de duas classificações histopatológicas com o padrão de imuno-marcação para KIT, a avaliação da proliferação celular e com a presença de mutações no c-KIT de mastocitomas cutâneos caninos

C-kit as a prognostic and therapeutic marker in canine cutaneous mast cell tumours: From laboratory to clinic

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