Mast Cells as Drivers of Disease and Therapeutic Targets

Siebenhaar, Frank; Redegeld, Frank A.; Bischoff, Stephan C.; Gibbs, Bernhard F.; Maurer, Marcus

doi:10.1016/j.it.2017.10.005

Cited by 111 publications

(115 citation statements)

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“…Mast cells are derived from pluripotent CD34+ haematopoietic progenitor cells and are normally found throughout the body in bone marrow, connective tissue, the skin, the gastrointestinal tract and the respiratory tract (Siebenhaar, Redegeld, Bischoff, Gibbs, & Maurer, ). Mast cells are normal components in both innate and adaptive immune responses to bacterial and parasitic infections and they are notorious for the role they play in allergic reactions (Siebenhaar et al, ). Mast cell activation in response to antigens causes mast cell degranulation and release of various cytokines and chemokines into the blood, thereby facilitating host immune responses (Siebenhaar et al, ).…”

Section: Mast Cell Function and Malignancymentioning

confidence: 99%

“…Mast cells are normal components in both innate and adaptive immune responses to bacterial and parasitic infections and they are notorious for the role they play in allergic reactions (Siebenhaar et al, ). Mast cell activation in response to antigens causes mast cell degranulation and release of various cytokines and chemokines into the blood, thereby facilitating host immune responses (Siebenhaar et al, ).…”

Section: Mast Cell Function and Malignancymentioning

confidence: 99%

“…Mast cell neoplasia is characterized by abnormal mast cell proliferation and accumulation (Bodemer et al, ; Siebenhaar et al, ). Neoplastic mast cell masses can spontaneously degranulate, releasing bioactive molecules which can exert serious and potentially fatal effects, such as anaphylaxis, gastric and duodenal ulceration or perforation, glomerular disease and haemorrhage.…”

Section: Mast Cell Function and Malignancymentioning

confidence: 99%

“…Cutaneous mastocytosis, also referred to as urticaria pigmentosa, is isolated to the skin, with no other organ involvement and represents 80% of all mastocytosis cases in humans (Siebenhaar et al, ). CM is more common in infants but can occur at any age and is more frequent in males than in females with a ratio of up to 1.8:1 (Bodemer et al, ; Kiszewski et al, ).…”

Section: Mastocytosis In Humansmentioning

confidence: 99%

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Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment

Tamlin

Bottema

Peaston

2019

Veterinary Medicine & Sci

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Mast cell neoplasia clinical presentation and biological behaviour vary considerably across mammalian species, ranging from a solitary benign mass to an aggressive systemic malignancy. Mutations in the KIT Proto‐Oncogene Receptor Tyrosine Kinase (KIT) gene are common molecular abnormalities involved in mast cell tumorigenesis. KIT mutations often occur in dog, cat and human neoplastic mast cells and result in altered Kit protein structure and function. In dogs, certain KIT mutations are associated with more malignant and lethal disease. In contrast, KIT mutations in feline and human mast cell neoplasms are not correlated with prognosis, but are of value in diagnosis and treatment planning in humans. KIT genetic abnormalities have not been well investigated in other species, although aberrant cytoplasmic Kit protein staining detected in neoplasms of the ferret, horse and cow resembles aberrant Kit staining patterns detected in neoplastic mast cells of dogs, cats and humans. Mutations within KIT are classified as either regulatory‐type or enzymatic pocket‐type mutations according to their location within the KIT Proto‐Oncogene. Mutations within the enzymatic pocket domain confer tumour resistance to tyrosine kinase inhibitors (TKIs). Hence, knowledge of tumour KIT mutation status adds valuable information for optimizing patient treatment strategies. The use of TKIs in combination with conventional chemotherapeutics has opened a new treatment avenue for patients unresponsive to existing drugs. This review highlights the similarities and differences of mast cell neoplasia in mammals with a special focus on the involvement of KIT in the canine and feline forms in comparison to human mast cell neoplasia.

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Section: Mast Cell Function and Malignancymentioning

confidence: 99%

Section: Mast Cell Function and Malignancymentioning

confidence: 99%

Section: Mast Cell Function and Malignancymentioning

confidence: 99%

Section: Mastocytosis In Humansmentioning

confidence: 99%

See 2 more Smart Citations

Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment

Tamlin

Bottema

Peaston

2019

Veterinary Medicine & Sci

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“…Numerous acute and chronic allergic responses such as airway constriction, mucous production, recruitment of major effector cells into tissue sites, and enhancement of pro‐inflammatory cytokine production are induced by these mediators (Galli, Tsai, & Piliponsky, ; Jutel, Blaser, & Akdis, ). Hence, mast cell degranulation is considered as a therapeutic target for the development of various anti‐allergic drugs so far (Siebenhaar, Redegeld, Bischoff, Gibbs, & Maurer, ).…”

Section: Introductionmentioning

confidence: 99%

The role of myricetin fromRhodomyrtus tomentosa(Aiton) Hassk fruits on downregulation of FcɛRI‐mediated mast cell activation

Kim

et al. 2020

J Food Biochem

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Rhodomyrtus tomentosa was reported to contain various bioactive metabolites, especially phenolic compounds. In the present study, the suppressive activity of phenolic compound from R. tomentosa fruits on mast cell activation was investigated in vitro. The result showed that myricetin was isolated from R. tomentosa fruits and its characterization was identified by nuclear magnetic resonance spectroscopy. Notably, myricetin was found to be effective in inhibition of mast cell degranulation by attenuating the release of β‐hexosaminidase and the elevation of intracellular calcium. Moreover, myricetin exhibited inhibitory effect on the production of IL‐4 and Tumor necrosis factor alpha (TNF‐α) in a concentration‐dependent manner. Furthermore, high antioxidant activity of myricetin due to scavenging 1,1‐diphenyl‐2‐picryl‐hydrazyl (DPPH) and ABTS+ radicals was also evidenced. Notably, the activation of FcɛRI‐mediated signaling molecules including Syk, PLCγ, and NF‐κB was also suppressed by myricetin treatment. Accordingly, myricetin from R. tomentosa fruits could be suggested as a functional food for the amelioration of allergic diseases. Practical applications Polyphenol have been shown to exert various biological activities and health beneficial effects. Results from the present study revealed that myricetin from R. tomentosa fruits possesses the inhibitory effect on allergic response in mast cells. Therefore, myricetin from R. tomentosa fruits could be developed as a functional ingredient for the amelioration of allergic diseases.

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