Mast cells in goldfish (<i>Carassius auratus</i>) gut: Immunohistochemical characterization

Alesci, Alessio; Pergolizzi, Simona; Fumia, Angelo; Calabrò, Concetta; Cascio, Patrizia Lo; Lauriano, Eugenia Rita

doi:10.1111/azo.12417

Cited by 37 publications

(22 citation statements)

References 132 publications

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“…TLRs, found in all classes of vertebrates [ 47 , 48 , 49 ], are physically and genotypically highly conserved receptors [ 50 , 51 ] that are involved in immune response [ 52 ]. Phylogenetically, TLRs—particularly TLR-2—have been characterized in urochordates (tunica and endostyle of ascidian Styela plicata) [ 53 , 54 ], cartilaginous fishes [ 10 ], bony fishes [ 55 ], and other upper vertebrates [ 48 , 56 ].…”

Section: Methodsmentioning

confidence: 99%

Confocal Characterization of Intestinal Dendritic Cells from Myxines to Teleosts

Alesci

Capillo

Fumia

et al. 2022

Biology

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Dendritic cells (DCs) are antigen-presenting cells (APCs) that regulate the beginning of adaptive immune responses. The mechanisms of tolerance to antigens moving through the digestive tract are known to be regulated by intestinal DCs. Agnatha and Gnathostoma are descendants of a common ancestor. The Ostracoderms gave rise to Cyclostomes, whereas the Placoderms gave rise to Chondrichthyes. Sarcopterygii and Actinopterygii are two evolutionary lines of bony fishes. Brachiopterygii and Neopterygii descend from the Actinopterygii. From Neopterygii, Holostei and Teleostei evolved. Using immunohistochemistry with TLR-2, Langerin/CD207, and MHC II, this study aimed to characterize intestinal DCs, from myxines to teleosts. The findings reveal that DCs are positive for the antibodies tested, highlighting the presence of DCs and DC-like cells phylogenetically from myxines, for the first time, to teleosts. These findings may aid in improving the level of knowledge about the immune system’s evolution and these sentinel cells, which are crucial to the body’s defense.

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Section: Methodsmentioning

confidence: 99%

Confocal Characterization of Intestinal Dendritic Cells from Myxines to Teleosts

Alesci

Capillo

Fumia

et al. 2022

Biology

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“…The peroxidase activity of the sections was determined by incubating them in a solution of 0.02% diaminobenzidine (DAB) and 0.015% hydrogen peroxide for 1–5 min at room temperature. [ 58 ]. After being rinsed in PBS, sections were dehydrated, mounted, and viewed with a Zeiss Axioskop 2 plus microscope and a Sony Digital Camera DSC-85.…”

Section: Methodsmentioning

confidence: 99%

Histological and Chemical Analysis of Heavy Metals in Kidney and Gills of Boops boops: Melanomacrophages Centers and Rodlet Cells as Environmental Biomarkers

Alesci

Cicero

Fumia

et al. 2022

Toxics

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Industrialization has resulted in a massive increase in garbage output, which is frequently discharged or stored in waterways like rivers and seas. Due to their toxicity, durability, bioaccumulation, and biomagnification, heavy metals (such as mercury, cadmium, and lead) have been identified as strong biological poisons. Their presence in the aquatic environment has the potential to affect water quality parameters and aquatic life in general. Teleosts’ histopathology provides a sensitive indicator of pollutant-induced stress, because their organs have a central role in the transformation of different active chemical compounds in the aquatic environment. In particular, the gills, kidneys, and liver are placed at the center of toxicological studies. The purpose of this study is to examine the morphological changes caused by heavy metals in the kidney and gills of Boops boops, with a focus on melanomacrophages centers (MMCs) and rodlet cells (RCs) as environmental biomarkers, using histological and histochemical stainings (hematoxylin/eosin, Van Gieson trichrome, Periodic Acid Schiff reaction, and Alcian Blue/PAS 2.5), and immunoperoxidase methods. Our findings show an increase of MMCs and RCs linked to higher exposure to heavy metals, confirming the role of these aggregates and cells as reliable biomarkers of potential aquatic environmental changes reflected in fish fauna. The cytological study of RCs and MMCs could be important in gaining a better understanding of the complicated immune systems of teleosts.

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“…Mast cells are related to innate immunity and primarily responsible for acute inflammatory processes [ 132 ]. Once activated, these cells secrete several substances contained in the cytoplasmic granules such as heparin and histamine, nitric oxide (NO), leukotrienes, and interleukins such as IL-8, IL-17, and IL-22 [ 133 , 134 ].…”

Section: Cell Types Involved In the Pathogenesis Of Psoriasismentioning

confidence: 99%

Relationship between Immune Cells, Depression, Stress, and Psoriasis: Could the Use of Natural Products Be Helpful?

et al. 2022

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Psoriasis is one of the most widespread chronic inflammatory skin diseases, affecting about 2%–3% of the worldwide adult population. The pathogenesis of this disease is quite complex, but an interaction between genetic and environmental factors has been recognized with an essential modulation of inflammatory and immune responses in affected patients. Psoriatic plaques generally represent the clinical psoriatic feature resulting from an abnormal proliferation and differentiation of keratinocytes, which cause dermal hyperplasia, skin infiltration of immune cells, and increased capillarity. Some scientific pieces of evidence have reported that psychological stress may play a key role in psoriasis, and the disease itself may cause stress conditions in patients, thus reproducing a vicious cycle. The present review aims at examining immune cell involvement in psoriasis and the relationship of depression and stress in its pathogenesis and development. In addition, this review contains a focus on the possible use of natural products, thus pointing out their mechanism of action in order to counteract clinical and psychological symptoms.

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Mast cells in goldfish (Carassius auratus) gut: Immunohistochemical characterization

Cited by 37 publications

References 132 publications

Confocal Characterization of Intestinal Dendritic Cells from Myxines to Teleosts

Confocal Characterization of Intestinal Dendritic Cells from Myxines to Teleosts

Histological and Chemical Analysis of Heavy Metals in Kidney and Gills of Boops boops: Melanomacrophages Centers and Rodlet Cells as Environmental Biomarkers

Relationship between Immune Cells, Depression, Stress, and Psoriasis: Could the Use of Natural Products Be Helpful?

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