Mast cells in rheumatoid arthritis

Maruotti, Nicola; Crivellato, Enrico; Cantatore, Francesco Paolo; Vacca, Angelo; Ribatti, Doménico

doi:10.1007/s10067-006-0305-3

Cited by 139 publications

(157 citation statements)

References 42 publications

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“…Monocytes and neutrophils are early effectors in the joint, and the numbers of these cells correlate with disease activity and radiographic progression in RA (36,37). Monocyte/ macrophages and neutrophils are a major source of cytokines and proinflammatory mediators, including tumor necrosis factor ␣ (TNF␣) (37,38), that enhance cell recruitment and amplify the inflammatory milieu. Fibrocytes secrete cytokines and proinflammatory mediators, including CXCL1 (growth-related oncogene ␣) and CXCL8 (IL-8) (10).…”

Section: Discussionmentioning

confidence: 99%

Circulating fibrocytes contribute to the pathogenesis of collagen antibody–induced arthritis

Galligan¹,

Fish²

2012

Arthritis & Rheumatism

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Objective. Rheumatoid arthritis (RA) is a systemic autoimmune disease resulting in joint inflammation. Fibroblast-like synoviocytes in affected joints are responsible for pannus formation and cytokine/ chemokine production, resulting in leukocyte recruitment and bone/cartilage destruction. Previously, we identified a multipotent stem cell population of activated fibrocytes in the blood of patients with RA that may have a role in disease pathogenesis, perhaps as fibroblast-like synoviocyte precursors. The aim of this study was to further characterize the contribution of circulating fibrocytes to the pathogenesis of RA.Methods. Circulating fibrocytes were isolated from mice with collagen-induced arthritis and transferred intravenously into recipient mice with collagen antibody-induced arthritis (CAIA). The activation status of circulating fibrocytes was determined using multidimensional phosphoflow cytometric analysis of the signaling effectors STAT-5, STAT-1, AKT, and JNK. Circulating fibrocyte trafficking and matrix metalloproteinase (MMP) activity were assessed in real time using fluorescence molecular tomography, specifically labeling circulating fibrocytes with CellVue Maroon and measuring MMP activity using MMPSense 680.Results. The numbers of circulating fibrocytes were increased early during the onset of CAIA, concomitant with their activation, as measured by phosphorylation of STAT-5. Adoptive transfer of circulating fibrocytes augmented disease scores and increased class II major histocompatibility complex expression and peripheral blood phosphoactivation profiles in recipient mice with CAIA. Notably, adoptively transferred fluorescence-labeled circulating fibrocytes rapidly migrated into the affected joints of recipient mice with CAIA, and this was associated with augmented neutrophil recruitment into affected joints and MMP activation.Conclusion. Circulating fibrocytes migrate to joints and influence the onset of disease processes in arthritis.

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Section: Discussionmentioning

confidence: 99%

Circulating fibrocytes contribute to the pathogenesis of collagen antibody–induced arthritis

Galligan¹,

Fish²

2012

Arthritis & Rheumatism

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“…IL-6 promotes synovitis by inducing neovascularisation via vascular endothelial growth factor (VEGF)-stimulated pannus proliferation, resulting in infiltration of inflammatory cells and synovial hyperplasia [17]. In terms of joint erosion, IL-6 causes bone resorption by inducing osteoclast formation via the induction of RANKL in synovial cells [18,19], and cartilage degeneration by producing matrix metalloproteinases (MMPs) in synovial cells and chondrocytes [20,21].…”

Section: The Role Of Interleukin-6 In the Pathogenesis Of Rheumatoid mentioning

confidence: 99%

Targeting Interleukin-6 in Rheumatoid Arthritis

Yusof

Emery

2013

Drugs

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“…Thus, examination of additional specimens might reveal cases of higher-grade synovitis. Increased synovial vascularization has been described in chronic arthropathies 4,7,[11][12][13] . Vascular density was nearly twice as high in the HCV specimens as in normal synovium ( Figure 2C), possibly adding HCV-associated arthritis to the arthropathies characterized by increased angiogenesis.…”

Section: To the Editormentioning

confidence: 99%