Mast Cells Respond to Candida albicans Infections and Modulate Macrophages Phagocytosis of the Fungus

Zuani, Marco De; Paolicelli, Giuseppe; Zelante, Teresa; Renga, Giorgia; Romani, Luigina; Arzese, Alessandra; Pucillo, Carlo; Frossi, Barbara

doi:10.3389/fimmu.2018.02829

Cited by 25 publications

(24 citation statements)

References 48 publications

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“…Activated mast cells enhance macrophage functionality by improving their crawling ability and chemotaxis in response to C. albicans stimulation (De Zuani et al . 2018 ). Meanwhile, resting mast cells inhibit the phagocytosis of C. albicans by macrophages, which suggests a role for mast cells in the maintenance of commensalism (De Zuani et al .…”

Section: The Hostmentioning

confidence: 99%

The impact of the Fungus-Host-Microbiota interplay uponCandida albicansinfections: current knowledge and new perspectives

d’Enfert

Kaune

Alaban

et al. 2020

FEMS Microbiology Reviews

213

134

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Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial barriers and immune defences. Their perturbation can lead to fungal outgrowth and the development of mucosal infections such as oropharyngeal or vulvovaginal candidiasis, and patients with compromised immunity are susceptible to life-threatening systemic infections. The importance of the interplay between fungus, host and microbiota in driving the transition from C. albicans commensalism to pathogenicity is widely appreciated. However, the complexity of these interactions, and the significant impact of fungal, host and microbiota variability upon disease severity and outcome, are less well understood. Therefore, we summarise the features of the fungus that promote infection, and how genetic variation between clinical isolates influences pathogenicity. We discuss antifungal immunity, how this differs between mucosae, and how individual variation influences a person's susceptibility to infection. Also, we describe factors that influence the composition of gut, oral and vaginal microbiotas, and how these affect fungal colonisation and antifungal immunity. We argue that a detailed understanding of these variables, which underlie fungal-host-microbiota interactions, will present opportunities for directed antifungal therapies that benefit vulnerable patients.

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Section: The Hostmentioning

confidence: 99%

The impact of the Fungus-Host-Microbiota interplay uponCandida albicansinfections: current knowledge and new perspectives

d’Enfert

Kaune

Alaban

et al. 2020

FEMS Microbiology Reviews

213

134

View full text Add to dashboard Cite

show abstract

“…A dual role of IL-9 has been reported in gastrointestinal candidiasis [105]. Studies in mice showed that IL-9 is likely to modulate vaginal response to Candida in a time-dependent manner, initially favoring inflammation via NLRP3 activation and then tolerance to the fungus by stimulating IL-1Ra production, mast cell (MC) engagement and macrophage crawling [106,107]. Interestingly, as the IL-9/MC axis contributes to chronic allergic inflammation [108] and is associated in a sex-specific manner with IgE levels in cystic fibrosis [109], it may lead to the hypothesis that VVC is an allergic reaction to the ability of Candida-specific IgE and prostaglandin E2 (PGE 2 ) to inhibit vaginal cell-mediated immune response [110].…”

Section: Immunology: Rvvc As An Autoinflammatory Diseasementioning

confidence: 99%

Recurrent Vulvovaginal Candidiasis: An Immunological Perspective

et al. 2020

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Vulvovaginal candidiasis (VVC) is a widespread vaginal infection primarily caused by Candida albicans. VVC affects up to 75% of women of childbearing age once in their life, and up to 9% of women in different populations experience more than three episodes per year, which is defined as recurrent vulvovaginal candidiasis (RVVC). RVVC results in diminished quality of life as well as increased associated healthcare costs. For a long time, VVC has been considered the outcome of inadequate host defenses against Candida colonization, as in the case of primary immunodeficiencies associated with persistent fungal infections and insufficient clearance. Intensive research in recent decades has led to a new hypothesis that points toward a local mucosal overreaction of the immune system rather than a defective host response to Candida colonization. This review provides an overview of the current understanding of the host immune response in VVC pathogenesis and suggests that a tightly regulated fungus–host–microbiota interplay might exert a protective role against recurrent Candida infections.

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“…Phagocytosis is at once an ancient and physiologically fundamental mechanism for safeguarding host health against microbial invasion 27,28 . The dynamic and intricate nature of the protein machinery at work during phagocytosis necessitates ever better scope and resolution in proteomic analysis to provide a refined understanding of the process at the systems level.…”

Section: Discussionmentioning

confidence: 99%

Hemocyte phagosomal proteome is dynamically shaped by cytoskeleton remodeling and interorganellar communication with endoplasmic reticulum during phagocytosis in a marine invertebrate, Crassostrea gigas

Mao

Wong

et al. 2020

Sci Rep

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phagosomes are task-force organelles of innate immune systems, and evolutionary diversity and continuity abound in the protein machinery executing this coordinately regulated process. in order to clarify molecular mechanisms underlying phagocytosis, we studied phagocyte response to beads and Vibrio species, using hemocytes of the Pacific oysters (Crassostrea gigas) as a marine invertebrate model. Phagosomes from different stages of phagocytosis were isolated by density-gradient centrifugation, and more than 400 phagosome-associated proteins were subsequently identified via high-throughput quantitative proteomics. In modeling key networks of phagosomal proteins, our results support the essential roles of several processes driving phagosome formation and maturation, including cytoskeleton remodeling and signal transduction by Rab proteins. Several endoplasmic reticulum (ER)-associated proteins were identified, while live cell imaging confirms an apparent intimate interaction between the ER and phagosomes. In further quantitative proteomic analysis, the signal transducers CgRhoGDi and CgPI4K were implicated. Through experimental validation, CgRhoGDi was shown to negatively regulate actin cytoskeleton remodeling in the formation of oyster phagosomes, while CgPI4K signaling drives phagosome maturation and bacterial killing. Our current work illustrates the diversity and dynamic interplay of phagosomal proteins, providing a framework for better understanding host-microbe interactions during phagosome activities in under-examined invertebrate species.

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Mast Cells Respond to Candida albicans Infections and Modulate Macrophages Phagocytosis of the Fungus

Cited by 25 publications

References 48 publications

The impact of the Fungus-Host-Microbiota interplay uponCandida albicansinfections: current knowledge and new perspectives

The impact of the Fungus-Host-Microbiota interplay uponCandida albicansinfections: current knowledge and new perspectives

Recurrent Vulvovaginal Candidiasis: An Immunological Perspective

Hemocyte phagosomal proteome is dynamically shaped by cytoskeleton remodeling and interorganellar communication with endoplasmic reticulum during phagocytosis in a marine invertebrate, Crassostrea gigas

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