Mastocytosis in Childhood

Heide, Rogier; Tank, Bhupendra; Oranje, Arnold P.

doi:10.1046/j.1525-1470.2002.00110.x

Cited by 71 publications

(87 citation statements)

References 48 publications

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“…Most mastocytosis cases present in children under the age of 2 years where it is usually confined to the skin and runs a benign, albeit bothersome, course, with resolution in most cases at approximately 9-10 years of age [1,6,13,15]. Over one-half of children with mastocytosis are symptomatic, and the most common symptoms include flushing and pruritis, mostly related to mastocyte release of histamine, prostaglandin-D2 (PG-2), and leukotriene-C4 [1,4,[16][17][18][19].…”

Section: Clinical Coursementioning

confidence: 99%

“…Fewer than one-half of adolescent cases progress into adulthood, where the course may become systemic in up to 30 % of affected children, usually as an indolent form [13,15,17,19]. It is unclear which disease subtype seen in adolescence will progress into the adult form of the disease [25].…”

Section: Clinical Coursementioning

confidence: 99%

“…Because bone marrow involvement is rare in children, bone marrow biopsy is pursued in all suspected adult cases but reserved for only those pediatric patients with systemic signs or symptoms, serum tryptase levels [20 ng/mL, organomegaly, or for those with MIS extending into puberty [12,13]. In children, serum tryptase levels are monitored, with examination for other signs and symptoms of systemic disease (cytopenia, leukocytosis, abnormal differential count, hepatomegaly, lymphadenopathy) until puberty [12].…”

Section: Diagnosismentioning

confidence: 99%

“…In children, serum tryptase levels are monitored, with examination for other signs and symptoms of systemic disease (cytopenia, leukocytosis, abnormal differential count, hepatomegaly, lymphadenopathy) until puberty [12]. Tryptase is a protease specific for and present in all mast cells, and serum levels may correlate with mast cell burden, especially after activation [1,4,13,35,38,39]. In a significant number of both children and adults with mastocytosis confined to the skin, however, the serum tryptase level may be normal (1-15 ng/mL) [13,40].…”

Section: Diagnosismentioning

confidence: 99%

“…Under a currently recognized WHO-classification scheme, mastocytosis is also subdivided into two general groups, a cutaneous form and a systemic form [12]. Cutaneous mastocytosis subtypes include urticaria pigmentosa (the overwhelming majority of children with mastocytosis), solitary cutaneous mastocytoma (10-35 % of children with skin disease), and diffuse cutaneous mastocytosis (seen almost exclusively in children) [1,[12][13][14]. The more severe or systemic forms of mastocytosis, involving the bone marrow or other extracutaneous sites, are typically seen in the adult population but in only approximately 10 % of children with cutaneous disease [5].…”

Section: Introductionmentioning

confidence: 99%

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Anesthetic considerations in pediatric mastocytosis: a review

Klein

Misseldine

2013

J Anesth

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Mastocytosis is an orphan disease rarely encountered by practicing anesthesiologists. Children with mastocytosis often present for procedures or surgery requiring anesthesia. Because many of the medications commonly used in pediatric anesthesia have been reported to initiate mast cell activation, parents are often very anxious about their child's perioperative experience. Laboratory investigations of serum histamine assays associated with different anesthetic drugs have not been shown to predict mast cell degranulation in these patients. However, the pediatric literature suggests that children with disease limited to the skin rarely suffer serious side effects from anesthesia, and there are no reported fatalities. Preoperative prophylaxis is usually based on expert opinion and case reports. Detailed tables summarizing reports of anesthetic medications used for children with mastocytosis undergoing anesthesia, reported side effects, and suggested prophylaxis regimens are included in this review.

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Section: Clinical Coursementioning

confidence: 99%

Section: Clinical Coursementioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Anesthetic considerations in pediatric mastocytosis: a review

Klein

Misseldine

2013

J Anesth

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Cognitive, neuropsychiatric and neurological alterations in mastocytosis: A systematic review

Sagües‐Sesé,

García‐Casares,

Álvarez‐Twose

2023

Clinical & Translational All

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BackgroundMastocytosis manifests with multisystemic symptoms, often involving the nervous system. Numerous cognitive, neuropsychiatric and neurological alterations have been reported in multiple observational studies.MethodsWe performed a qualitative systematic literature review of reported data consulting the electronic databases Medline, Scopus, Web of Science, Cochrane, and BASE until June 2023.ResultsWe selected 24 studies in which the majority showed that a high proportion of mastocytosis patients suffer cognitive, neuropsychiatric and neurological alterations. The most common disorders and estimated ranges of frequency observed in adults were depression (68%–75%), anxiety, high stress or irritability (27%–54%), cognitive impairment (27%–39%, primarily affecting memory skills), and headaches (55%–69%). Attention challenges and learning difficulties were reported in children at a rate of 13%, while neurodevelopmental disorders occurred at rates of 8%–12%. Frequent white abnormalities in mastocytosis patients with concomitant psychocognitive symptoms have been reported although neuroimaging studies have been performed rarely in this population.ConclusionFurther studies with more comprehensive and homogeneous evaluations and neuroimaging and histological analysis should be performed for a better understanding of these manifestations. An earlier detection and proper management of these symptoms could greatly improve the quality of life of these patients.

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Influence of Heat Treatment on the Performance Characteristics of a Plastic Mold Steel

Hill

Raab

Weber

et al. 2011

steel research int.

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Processing of polymers depends on corrosion‐ and wear resistant tool materials being in direct contact with the feedstock material. Plastic mold steels, a special group of tool steels, are successfully applied here, offering both a good wear and corrosion resistance. The lifetime of tools used for plastic processing not only depends on wear and corrosion resistance but also on the mechanical properties of the tool material for example, its flexural strength. In this work, mechanical tests of a commercial plastic mold steel were performed and related to the heat treatment. A close correlation of the amount of retained austenite and carbides and the mechanical properties was encountered. The paper discusses strategies to optimize the mechanical properties by an adequate heat treatment with regard to the resulting corrosion and wear resistance.

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Mastocytosis in Childhood

Cited by 71 publications

References 48 publications

Anesthetic considerations in pediatric mastocytosis: a review

Anesthetic considerations in pediatric mastocytosis: a review

Cognitive, neuropsychiatric and neurological alterations in mastocytosis: A systematic review

Influence of Heat Treatment on the Performance Characteristics of a Plastic Mold Steel

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