Matching of feedback inhibition with excitation ensures fidelity of information flow in the anterior piriform cortex

Sheridan, David C.; Hughes, Alexander R.; Erdélyi, Ferenc; Szabó, Gábor; Hentges, Shane T.; Schoppa, Nathan E.

doi:10.1016/j.neuroscience.2014.06.033

Cited by 13 publications

(20 citation statements)

References 38 publications

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“…Previous studies used higher LOT stimulation intensities or multiple pulses that evoked spike responses in excitatory neurons and recruited recurrent inhibition from L2/3 interneurons (27,28). To investigate excitation and inhibition recruited by intracortical circuits in the absence of afferent drive, we electrically stimulated the border of L2/3.…”

Section: Resultsmentioning

confidence: 99%

“…There have been conflicting descriptions of the contributions of feedforward and recurrent inhibition to odor processing (3,24,27,28,32). For example, it has been suggested that feedforward inhibition is broadly tuned in vivo (3).…”

Section: Afferent Vs Intracortical Recruitment In Different Principamentioning

confidence: 99%

“…inhibition (27,28). These discrepancies likely arise because each study focused on a different cell class and used different stimulation regimes.…”

Section: Afferent Vs Intracortical Recruitment In Different Principamentioning

confidence: 99%

“…Within the cortex, principal neurons send axon collaterals throughout L2/3 and to an intracortical fiber tract in L1b (25,26). Intracortical excitation recruits a number of interneuron classes within L2/3 that, in turn, provide recurrent inhibition to principal neurons (20,24,27,28). Stimulation of the LOT evokes shortlatency feedforward inhibition that targets principal neuron dendrites, as well as long-latency, recurrent inhibition that is somatic (24,28,29).…”

mentioning

confidence: 99%

“…However, in vivo and in vitro studies focusing on different principal neuron classes have led to conflicting reports of the relative contributions of feedforward and feedback inhibition during afferent odor processing (3,24,27,28,32). Furthermore, because of the disynaptic nature of inhibition, estimates of feedforward or recurrent inhibitory strength depend on the quality of afferent and intracortical excitatory recruitment, which varies with the different stimulation protocols used in each study.…”

mentioning

confidence: 99%

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Balanced feedforward inhibition and dominant recurrent inhibition in olfactory cortex

Large

Vogler

Mielo

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Throughout the brain, the recruitment of feedforward and recurrent inhibition shapes neural responses. However, disentangling the relative contributions of these often-overlapping cortical circuits is challenging. The piriform cortex provides an ideal system to address this issue because the interneurons responsible for feedforward and recurrent inhibition are anatomically segregated in layer (L) 1 and L2/3 respectively. Here we use a combination of optical and electrical activation of interneurons to profile the inhibitory input received by three classes of principal excitatory neuron in the anterior piriform cortex. In all classes, we find that L1 interneurons provide weaker inhibition than L2/3 interneurons. Nonetheless, feedforward inhibitory strength covaries with the amount of afferent excitation received by each class of principal neuron. In contrast, intracortical stimulation of L2/3 evokes strong inhibition that dominates recurrent excitation in all classes. Finally, we find that the relative contributions of feedforward and recurrent pathways differ between principal neuron classes. Specifically, L2 neurons receive more reliable afferent drive and less overall inhibition than L3 neurons. Alternatively, L3 neurons receive substantially more intracortical inhibition. These three features-balanced afferent drive, dominant recurrent inhibition, and differential recruitment by afferent vs. intracortical circuits, dependent on cell classsuggest mechanisms for olfactory processing that may extend to other sensory cortices.cortex | inhibition | olfaction

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Section: Resultsmentioning

confidence: 99%

Section: Afferent Vs Intracortical Recruitment In Different Principamentioning

confidence: 99%

“…inhibition (27,28). These discrepancies likely arise because each study focused on a different cell class and used different stimulation regimes.…”

Section: Afferent Vs Intracortical Recruitment In Different Principamentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Balanced feedforward inhibition and dominant recurrent inhibition in olfactory cortex

Large

Vogler

Mielo

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Odour perception: A review of an intricate signalling pathway

Tromelin

2015

Flavour & Fragrance J

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The perception of odours is the result of the complex processing of a signal, which initiates at peripheral receptors and ends in the brain. Along this pathway, olfactory signal processing proceeds through several steps; each step possesses its own complexity, and all steps are also intricately connected. This review aims to describe the main intricate steps of olfactory processing in mammals, some of which remain unclear, and the close associations and overlapping nature of these steps. The causes of both the complexity and the variability of olfactory signals are examined: the nature of olfactory receptors, involving the diversity of the genome; the spatial organization of the olfactory epithelium (OE) and the olfactory bulb (OB); connections in the OB and from the OB to the brain; integration and processing in the brain, which leads to the final perception of odours; and odour recognition and odour identification, which is associated with the difficulty to verbalize a reliable description of the perception in humans. Finally, the last part of this review encompasses recent progress made to decipher and understand olfactory coding and focuses on computational approaches

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Brain changes associated with thromboxane receptor antagonist SQ 29,548 treatment in a mouse model

Rebel

Urquhart

Puig

et al. 2015

J of Neuroscience Research

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The purpose of this study was to characterize behavioral and physiological effects of a selective thromboxane receptor (TP) antagonist, SQ 29,548, in the C57BL/6 mouse model. At six months of age, male mice were given either sham or drug intraperitoneal injections for three days at a dose of 2mg/kg each day. On the day after the final injection mice were subjected to behavioral testing paradigms before brain collection. Left hemisphere hippocampi were collected from all mice for protein analysis via western blot. Right brain hemispheres were fixed and imbedded in gelatin, and serially sectioned. The sections were immunostained using anti-c-Fos antibodies. Prostaglandin analysis was performed from remaining homogenized brain samples, minus the hippocampi. Injection of SQ 29,548 decreased selective brain prostaglandin levels compared to sham controls. This correlated with robust increases in limbic region c-Fos immunoreactivity in the SQ 29,548 injected mice. However, drug treated mice demonstrated no significant changes in relevant hippocampal protein levels compared to sham treatments, as determined by western blots. Surprisingly, injection of SQ 29,548 caused mixed changes in parameters of depression and anxiety-like behavior in the mice. In conclusion, the results indicate that administration of peripheral TP receptor antagonists alters brain levels of prostanoids and influences neuronal activity with only minimal alterations of behavior. Whether the drug affects neurons directly or through a secondary pathway involving endothelium or other tissues remains unclear.

show abstract

Matching of feedback inhibition with excitation ensures fidelity of information flow in the anterior piriform cortex

Cited by 13 publications

References 38 publications

Balanced feedforward inhibition and dominant recurrent inhibition in olfactory cortex

Balanced feedforward inhibition and dominant recurrent inhibition in olfactory cortex

Odour perception: A review of an intricate signalling pathway

Brain changes associated with thromboxane receptor antagonist SQ 29,548 treatment in a mouse model

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