Material properties in complement activation

Moghimi, S. Moein; Andersen, Alina Joukainen; Ahmadvand, Davoud; Wibroe, Peter P.; Andresen, Thomas Lars; Hunter, A. Christy

doi:10.1016/j.addr.2011.06.002

Cited by 237 publications

(202 citation statements)

References 76 publications

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“…For example, the complement classical and lectin pathway convertase (C4b2a), has a cross-sectional diameter of approximately 30 nm [5]. This makes its assembly and deposition on to the surface of a nanomaterial with high surface area (e.g.…”

Section: Contact Angle Measurementsmentioning

confidence: 99%

“…Together, these studies indicate that with increasing deposition of C3b on the surface,C3b complexes are formed which through multivalent attachment bind the substrate C5 with higher affinities, thereby converting the low affinity C3/C5 convertases to high affinity C5c [4]. On the other hand from a nanomaterial's point of view, understanding the molecular basis of its properties in complement activation could provide approaches to ideal material design and nanoengineering strategies for eliminating acute allergic responses to future nanomaterials for medical applications [5]. In this study a sandwich ELISA (Enzyme Linked Immunosorbent Assay) for C5c complement activation induced by biomaterials is validated.…”

Section: Introduction:-mentioning

confidence: 98%

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IN-VITRO IMMUNOCOMPATIBILITY & CHARACTERIZATION AT NANOSCALE OF THIN FILMS AND VASCULAR MEDICAL DEVICES.

Janjic¹,

Kavatzikidou²,

Karagkiozaki³

et al. 2017

IJAR

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Texture.Immunocompatibility comprises a complex response which depends both on the physico-chemical characteristics of the biomaterial and on the hereditary and acquired ability of the recipient to react. Objective: The objective of the present work was the comparative study of the immunocompatibility of different materials and their morphological characterization. Methods: The three types of thin films used in this work were the titanium nitride [TiN],Titanium [Ti] and the amorphous hydrogenated diamond-like carbon [a-C:H], which are deposited onto a silicon substrate by Magnetron Sputtering and Plasma-Enhanced Chemical Vapor Deposition (PECVD), respectively. Medical devices used in this study, were the silicon coated Latex irrigation catheter and the endoprosthesis such as vascular grafts [Dacron, PTFE] and stent grafts [Nitinol stent graft, Cobalt Chromium stent graft]. Bare silicon substrate and serum were used as a "negative" control and the Latex [elastomer-elastic hydrocarbon polymer] as a "positive" control. Complement C5 convertase [C5c] activation was assessed using the sandwich enzyme immunoassay-sandwich ELISA for the specific time periods [0min, 15 min, 30 min and 60 min] at wavelength of 450nm. The morphological characterization of the materials was conducted by Scanning Electron Microscopy (SEM). The study of biomaterials topography was conducted by Atomic Force Microscopy (AFM) and their surface wettability properties by Contact Angle measurements. Results: Our results show that both groups of materials (the nanomaterials and the medical devices) are not likely to cause any immunological adverse reaction and as a result might be characterized and selected as excellent candidates for medical applications. Conclusions: The effectiveness of the study is attributed to the measurement of a single factor in serum in order to acquire important information about the materials' properties e.g immunological response. The possibility to modify the above tested parameters during

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Section: Contact Angle Measurementsmentioning

confidence: 99%

Section: Introduction:-mentioning

confidence: 98%

IN-VITRO IMMUNOCOMPATIBILITY & CHARACTERIZATION AT NANOSCALE OF THIN FILMS AND VASCULAR MEDICAL DEVICES.

Janjic¹,

Kavatzikidou²,

Karagkiozaki³

et al. 2017

IJAR

View full text Add to dashboard Cite

show abstract

“…12,13,21,22,[44][45][46]50,51 Their nanoscale size, with all three dimensions ranging from 0.1 to 100 nm, happens to be the size range of the fundamental building blocks of biology (including DNA, proteins, viruses, ultrastructures and organelles). Thus, the ways in which engineered nanomaterials may interfere with the function of the host immune system and how these immunomodulatory activities may affect vaccines are increasingly important questions.…”

Section: Immunomodulatory Effects Of Nanomaterialsmentioning

confidence: 99%

“…In the following sections, the immunomodulatory activities of nanomaterials, including inflammasome activation, recruitment of immune cells and complement system activation, will be introduced. 12,13,21,22,33,34,[44][45][46][47][48][49][50][51][87][88][89][90] The potential mechanisms for these effects will also be discussed to facilitate an in-depth understanding of the inherent adjuvant activity of nanomaterials.…”

Section: Immunomodulatory Effects Of Nanomaterialsmentioning

confidence: 99%

“…For example, nanoparticles can induce inflammasome activation in macrophages and DCs, [44][45][46] enhance antigen presentation and APC maturation, 33,34 recruit immune cells, 21,22,47,48 direct T cell differentiation to a particular subtype, and activate the complement system. 12,13,[49][50][51] Therefore, nanomaterials constitute a multifunctional unit to integrate target delivery and immunomodulation effects for clinical use in vaccination.…”

Section: Introductionmentioning

confidence: 99%

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Applications of nanomaterials as vaccine adjuvants

Zhu

Wang

Nie³

2014

Human Vaccines & Immunotherapeutics

133

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Vaccine adjuvants are applied to amplify the recipient's specific immune responses against pathogen infection or malignancy. A new generation of adjuvants is being developed to meet the demands for more potent antigenspecific responses, specific types of immune responses, and a high margin of safety. Nanotechnology provides a multifunctional stage for the integration of desired adjuvant activities performed by the building blocks of tailor-designed nanoparticles. Using nanomaterials for antigen delivery can provide high bioavailability, sustained and controlled release profiles, and targeting and imaging properties resulting from manipulation of the nanomaterials' physicochemical properties. Moreover, the inherent immune-regulating activity of particular nanomaterials can further promote and shape the cellular and humoral immune responses toward desired types. The combination of both the delivery function and immunomodulatory effect of nanomaterials as adjuvants is thought to largely benefit the immune outcomes of vaccination. In this review, we will address the current achievements of nanotechnology in the development of novel adjuvants. The potential mechanisms by which nanomaterials impact the immune responses to a vaccine and how physicochemical properties, including size, surface charge and surface modification, impact their resulting immunological outcomes will be discussed. This review aims to provide concentrated information to promote new insights for the development of novel vaccine adjuvants.

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In VitroMethods in Immunotoxicity Assessment

Zhu

Evans

2016

Drug Discovery Toxicology

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Material properties in complement activation

Cited by 237 publications

References 76 publications

IN-VITRO IMMUNOCOMPATIBILITY & CHARACTERIZATION AT NANOSCALE OF THIN FILMS AND VASCULAR MEDICAL DEVICES.

IN-VITRO IMMUNOCOMPATIBILITY & CHARACTERIZATION AT NANOSCALE OF THIN FILMS AND VASCULAR MEDICAL DEVICES.

Applications of nanomaterials as vaccine adjuvants

In VitroMethods in Immunotoxicity Assessment

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