Materials for Bone and Joint Replacement

Surface characterization of the oxide layer grown on TiNbZr and TiNbAl alloys

“…1,2 However, there exists a scientific controversy on the cytotoxicity of elemental vanadium. 3,4 For this reason, new vanadium-free Ti alloys are currently being evaluated for biomedical applications.…”

Metals for joint replacement

“…Bicon " (Plus Orthopedics), allofit " (Zimmer) and TOP acetabular cup system " (Waldemar link). The properties of Ti alloys include good biocompatibility, low modulus of elasticity and resistance to fatigue and corrosion (Kohn and Ducheyne 1992;Willert et al, 1996). Cementless stems are more resistant to osteolysis and mechanical failure when compared with similar cemented stems (Emerson et al, 2002;laupacis et al, 2002;Head et al, 1995).…”

Porous Coatings in Orthopedics

“…95,97,99,105,107,108 The self-assembly of apatite within the pores of a porous or porous-coated implant enhances cell adhesion, proliferation, and osteogenic differentiation, as well as modulates cytoskeletal organization and cell motility in vitro. 114 Differences in ceramic chemistry and structure lead to differences in biological response both in vitro (e.g., cell attachment and proliferation, protein synthesis, RNA transcription) 109,115,116 and in vivo (e.g., cell differentiation, amount and rate of bone formation, intensity, or duration of inflammatory response). 110 An additional benefit of the biomimetic processing conditions is that growth factors can be incorporated into the coating without denaturing, enabling a dual conductive/inductive approach.…”