Materials for Use in the Eye

Refojo, Miguel F.

doi:10.1007/978-1-4684-7744-3_21

Cited by 4 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polymeric hydrogel microspheres have re-cently attracted attention because of their permanent spherical shape. [5][6][7][8][9] Many researchers found hydrogel microspheres can be used as carrier matrices in a wide variety of mucosal, biological, and biomedical applications such as ophthalmology, 10 drug delivery, 11 orthopedics, 12 and medical devices. 13 The ability of natural tissue to grow into hydrogel matrices makes them very attractive for biomedical uses.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and in vitro release of ibuprofen from poly(MMA‐HEMA) copolymeric core–shell hydrogel microspheres for biomedical applications

Sivakumar

Rao

2002

J of Applied Polymer Sci

View full text Add to dashboard Cite

This article describes the development of a new crosslinked poly(methyl methacrylate-2-hydroxyethyl methacrylate) copolymeric core-shell hydrogel microsphere incorporated with ibuprofen for potential applications in bone implants. Initially poly(methyl methacrylate) (PMMA) core microspheres were prepared by free-radical initiation technique. On these core microspheres, 2-hydroxyethyl methacrylate (HEMA) was polymerized by swelling PMMA microspheres with the HEMA monomer by using ascorbic acid and ammonium persulfate. Crosslinking monomers such as ethylene glycol dimethacrylate (EGDMA) has also been included along with HEMA for polymerization. By this technique, it was possible to obtain core-shell-type microspheres. The core is a hard PMMA microsphere having a hydrophilic poly(HEMA) shell coat on it. These microspheres are highly hydrophilic as compared to PMMA microspheres. The size of the hydrogel microspheres almost doubled when swollen in benzyl alcohol. These microspheres were characterized by various techniques such as optical microscopy, scanning electron microscopy, Fourier-transformed infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry. The particle size of both microspheres was analyzed by using Malvern Master Sizer/E particle size analyzer. The in vitro release of ibuprofen from both microspheres showed near zero-order patterns.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and in vitro release of ibuprofen from poly(MMA‐HEMA) copolymeric core–shell hydrogel microspheres for biomedical applications

Sivakumar

Rao

2002

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…PolyHEMA is extensively used for the production of soft contact lenses because of its well known biocompatibility and excellent molding properties (Refojo, 1975). On the other hand, most hard contact lenses are made from polyMMA.…”

Section: Materials For Ocular Applicationsmentioning

confidence: 99%