Synthesis, characterization, and in vitro release of ibuprofen from poly(MMA‐HEMA) copolymeric core–shell hydrogel microspheres for biomedical applications

Abstract

This article describes the development of a new crosslinked poly(methyl methacrylate-2-hydroxyethyl methacrylate) copolymeric core-shell hydrogel microsphere incorporated with ibuprofen for potential applications in bone implants. Initially poly(methyl methacrylate) (PMMA) core microspheres were prepared by free-radical initiation technique. On these core microspheres, 2-hydroxyethyl methacrylate (HEMA) was polymerized by swelling PMMA microspheres with the HEMA monomer by using ascorbic acid and ammonium persulfate. Crosslinking monomers such as ethylene glycol dimethacrylate (EGDMA) has also been included along with HEMA for polymerization. By this technique, it was possible to obtain core-shell-type microspheres. The core is a hard PMMA microsphere having a hydrophilic poly(HEMA) shell coat on it. These microspheres are highly hydrophilic as compared to PMMA microspheres. The size of the hydrogel microspheres almost doubled when swollen in benzyl alcohol. These microspheres were characterized by various techniques such as optical microscopy, scanning electron microscopy, Fourier-transformed infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry. The particle size of both microspheres was analyzed by using Malvern Master Sizer/E particle size analyzer. The in vitro release of ibuprofen from both microspheres showed near zero-order patterns.

Acrylic polymeric nanospheres for the release and recognition of molecules of clinical interest

“…The absence of functional groups able to exploit significant polar interaction (hydrogen bonding) hinders the development of materials with recognition properties based on PMMA alone. Results obtained clearly show that the insertion of a limited amount of carboxylic groups into a polymethylmethacrylate matrix leads to polymeric systems which show drug release properties in accordance to the present expected standards (Sivakumar and Rao, 2002) and also are able to rebind selectively the template in organic solvents. Further work is necessary in order to provide these materials with comparable rebinding properties in media which simulate the body fluids in order to set them in biomaterials' application.…”

Slow Release of Urea as a Source of Nitrogen from Some Acrylamide and Acrylic Acid Hydrogels

“…The behavior of highly swollen hydrogels is, therefore, a function of the network characteristics. Controlled-release technology offers advantages over conventional formulations, such as maintaining the concentration [5,6] of the active agent between the minimum effect and toxic level and for masking of any odor. One of the most conventional applications of the hydrogels is their use in controlled-release systems [3] .…”

New acrylic microspheres for arterial embolization: Combining radiopacity for precise localization with immobilized thrombin to trigger local blood coagulation

“…A solution of PVA (1.25 g), PEG (1.50 g) and PVP (0.25 g) in 100 mL distilled water was magnetically stirred and heated to 85 1C. MMA, 4IEMA, MAA, BPO and TEGDMA were mixed, and this mixture was added dropwise to the stirred aqueous PVA-PEG-PVP solution [25]. After the addition, stirring at 85 1C was continued for 6 h. The microspheres precipitated immediately as stirring was stopped, and the supernatant was decanted carefully.…”