Materials Testing for the Development of Biocompatible Devices through Vat-Polymerization 3D Printing

González, Gustavo; Baruffaldi, Désirée; Martinengo, Cinzia; Angelini, Angelo; Chiappone, Annalisa; Roppolo, Ignazio; Pirri, Candido Fabrizio; Frascella, Francesca

doi:10.3390/nano10091788

Cited by 53 publications

(51 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, the DLP technology shows high resolution (~1 μm) and fast printing speed (3 mm/s −1 ) for the production of unique 3D objects [ 34 ]. The DLP printing, originally used just for prototyping, is now finding its application in several fields, such as in biomedics [ 35 ] where DLP is proposed for the production of customized medical devices [ 36 ], for tissue engineering [ 37 ] and drug delivery [ 38 ] but also in soft robotics [ 39 ], microfluidics [ 40 ], sensing [ 41 ] and several others fields.…”

Section: Introductionmentioning

confidence: 99%

3D Printing of PDMS-Like Polymer Nanocomposites with Enhanced Thermal Conductivity: Boron Nitride Based Photocuring System

et al. 2021

Self Cite

View full text Add to dashboard Cite

This study demonstrates the possibility of forming 3D structures with enhanced thermal conductivity (k) by vat printing a silicone–acrylate based nanocomposite. Polydimethylsiloxane (PDSM) represent a common silicone-based polymer used in several applications from electronics to microfluidics. Unfortunately, the k value of the polymer is low, so a composite is required to be formed in order to increase its thermal conductivity. Several types of fillers are available to reach this result. In this study, boron nitride (BN) nanoparticles were used to increase the thermal conductivity of a PDMS-like photocurable matrix. A digital light processing (DLP) system was employed to form complex structures. The viscosity of the formulation was firstly investigated; photorheology and attenuate total reflection Fourier-transform infrared spectroscopy (ATR-FTIR) analyses were done to check the reactivity of the system that resulted as suitable for DLP printing. Mechanical and thermal analyses were performed on printed samples through dynamic mechanical thermal analysis (DMTA) and tensile tests, revealing a positive effect of the BN nanoparticles. Morphological characterization was performed by scanning electron microscopy (SEM). Finally, thermal analysis demonstrated that the thermal conductivity of the material was improved, maintaining the possibility of producing 3D printable formulations.

show abstract

Section: Introductionmentioning

confidence: 99%

3D Printing of PDMS-Like Polymer Nanocomposites with Enhanced Thermal Conductivity: Boron Nitride Based Photocuring System

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…On the other hand, photopolymers are often more toxic due to their nature and the potential residues that remain following the photo-curing processes (132). Several studies considered 3D printed objects using SLA technology as toxic when used directly in biological applications without postprocessing (147)(148)(149). Accordingly, photoinitiators (e.g.…”

Section: Current 3d Printing Challenges and Limitationsmentioning

confidence: 99%

“…One of the reasons that have been suggested to underlie toxicity is the chemical composition of the 3D printing material itself. Often, the complete formulation of these materials is only known to the manufacturers, but photoinitiators and acrylate monomers are known to be toxic for living organisms (148). Material Residues remaining on the printed objects' surface can be washed with ethanol, sonication, and sterilised with UV light (148).…”

Section: Current 3d Printing Challenges and Limitationsmentioning

confidence: 99%

“…Often, the complete formulation of these materials is only known to the manufacturers, but photoinitiators and acrylate monomers are known to be toxic for living organisms (148). Material Residues remaining on the printed objects' surface can be washed with ethanol, sonication, and sterilised with UV light (148). Another study identified uncured residual monomers in the objects' surface using HPLC-MS, explaining their high toxicity, and suggested using a combination of residual photopolymer extraction via supercritical CO2 treatment and post-curing (147).…”

Section: Current 3d Printing Challenges and Limitationsmentioning

confidence: 99%

See 1 more Smart Citation

The Field Guide to 3D Printing in Microscopy

Rosario¹,

Heil²,

Mendes³

et al. 2021

Preprint

View full text Add to dashboard Cite

The maker movement has reached the optics labs, empowering researchers to actively create and modify microscope designs and imaging accessories. 3D printing has especially had a disruptive impact on the field, as it entails an accessible new approach in fabrication technologies, namely additive manufacturing, making prototyping in the lab available at low cost. Examples of this trend are taking advantage of the easy availability of 3D printing technology. For example, inexpensive microscopes for education have been designed, such as the FlyPi. Also, the highly complex robotic microscope OpenFlexure represents a clear desire for the democratisation of this technology. 3D printing facilitates new and powerful approaches to science and promotes collaboration between researchers, as 3D designs are easily shared. This holds the unique possibility to extend the open-access concept from knowledge to technology, allowing researchers from everywhere to use and extend model structures. Here we present a review of additive manufacturing applications in microscopy, guiding the user through this new and exciting technology and providing a starting point to anyone willing to employ this versatile and powerful new tool.

show abstract

“…Whereas powder bed fusion and binder jetting utilize powders as feedstock [ 6 , 7 ], and the point of difference is the basic additive manufacturing principle where the former is based on the selective fusion of material in the powder bed [ 8 ], and the latter is based on reactive curing of the material in the powder bed [ 9 ]. These processes and feedstock utilize thermal reaction bonding except for binder jetting which, despite being a powder bed-based platform, utilizes the basic AM principle of chemical reaction bonding, which is similar to the AM processes such as material jetting, and vat photopolymerization [ 10 , 11 ]. The SLS 3D printing process falls under powder bed fusion processes which involves a powder bed-based feedstock layer being selectively fused utilizing a thermal stimulus.…”

Section: Introductionmentioning

confidence: 99%

Impact of Laser Speed and Drug Particle Size on Selective Laser Sintering 3D Printing of Amorphous Solid Dispersions

et al. 2021

View full text Add to dashboard Cite

This research demonstrates the influence of laser speed and the drug particle size on the manufacturing of amorphous solid dispersions (ASD) and dosage forms thereof using selective laser sintering 3-dimensional (3D) printing. One-step manufacturing of ASD is possible using selective laser sintering 3D printing processes, however, the mechanism of ASD formation by this process is not completely understood and it requires further investigation. We hypothesize that the mechanism of ASD formation is the diffusion and dissolution of the drug in the polymeric carrier during the selective laser sintering (SLS) process and the drug particle size plays a critical role in the formation of said ASDs as there is no mixing involved in the sintering process. Herein, indomethacin was used as a model drug and introduced into the feedstock (Kollidon® VA64 and Candurin® blend) as either unprocessed drug crystals (particle size > 50 µm) or processed hot-melt extruded granules (DosePlus) with reduced drug particle size (<5 µm). These feedstocks were processed at 50, 75, and 100 mm/s scan speed using SLS 3D printing process. Characterization and performance testing were conducted on these tablets which revealed the amorphous conversion of the drug. Both MANOVA and ANOVA analyses depicted that the laser speed and drug particle size significantly impact the drug’s apparent solubility and drug release. This significant difference in performance between formulations is attributed to the difference in the extent of dissolution of the drug in the polymeric matrix, leading to residual crystallinity, which is detrimental to ASD’s performance. These results demonstrate the influence of drug particle size on solid-state and performance of 3D printed solid dispersions, and, hence, provide a better understanding of the mechanism and limitations of SLS 3D printing of ASDs and its dosage forms.

show abstract

Materials Testing for the Development of Biocompatible Devices through Vat-Polymerization 3D Printing

Cited by 53 publications

References 51 publications

3D Printing of PDMS-Like Polymer Nanocomposites with Enhanced Thermal Conductivity: Boron Nitride Based Photocuring System

3D Printing of PDMS-Like Polymer Nanocomposites with Enhanced Thermal Conductivity: Boron Nitride Based Photocuring System

The Field Guide to 3D Printing in Microscopy

Impact of Laser Speed and Drug Particle Size on Selective Laser Sintering 3D Printing of Amorphous Solid Dispersions

Contact Info

Product

Resources

About